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Medication Response & Drug Metabolism Testing

CYP2D6 · CYP2C19 · CYP2C9 · VKORC1 · CYP3A4

Genetic results require clinical confirmation and are interpreted together with your medical and family history. A qualified healthcare provider confirms any diagnosis — our counselors help you pick the right assay before you book.

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Medically reviewed by Dr. Robert Vance, MD, FACMG (Chief Medical Geneticist)

  • CLIA-Certified & CAP-Accredited
  • HIPAA-Compliant Quality System
  • Free Pre-Test Genetic Counselor Guidance
  • Nationwide & At-Home Sample Collection
6 tests in Medication Response & Drug Metabolism All tests A–Z →
First line

Comprehensive PGx Panel

Sample:
2 mL EDTA Whole Blood or Buccal Swab
TAT:
7–10 Business Days

$495

Test factsheet

Analysis of 50+ pharmacogenes for drug metabolism.

Sample requirements: 2 mL EDTA Whole Blood or Buccal Swab

Patient preparation: Follow the instructions on your collection kit.

Turnaround notes: 7-10 business days; results are released to your prescriber with the counseling summary.

May be considered for:

  • Planned therapy with a medication affected by CYP450 polymorphisms
  • Prior adverse drug reaction or therapeutic failure
  • Polypharmacy including antidepressants, antipsychotics or antiemetics
  • Chronic pain management or pre-operative planning
Reflex

CYP2D6 Genotyping

Sample:
2 mL EDTA Whole Blood
TAT:
5–7 Business Days

$250

Test factsheet

Star-allele genotyping of CYP2D6 covering poor through ultrarapid metabolizer states.

Sample requirements: 2 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 5–7 Business Days

May be considered for:

  • Codeine, tramadol, tamoxifen or SSRI therapy planned
  • Prior adverse drug reaction or therapeutic failure
  • Polypharmacy including antidepressants or antipsychotics
First line

CYP2C19 Genotyping

Sample:
2 mL EDTA Whole Blood
TAT:
5–7 Business Days

$250

Test factsheet

Star-allele genotyping of CYP2C19 for clopidogrel, PPI and SSRI response.

Sample requirements: 2 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 5–7 Business Days

May be considered for:

  • Clopidogrel or proton-pump inhibitor therapy planned
  • Prior stent thrombosis on clopidogrel
  • Prior adverse drug reaction or therapeutic failure
First line

CYP2C9 / VKORC1 Warfarin Genotyping

Sample:
2 mL EDTA Whole Blood
TAT:
5–7 Business Days

$300

Test factsheet

Pharmacogenomic dosing support for warfarin initiation and stabilization.

Sample requirements: 2 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 5–7 Business Days

May be considered for:

  • Warfarin initiation planned
  • Unstable INR or difficult warfarin titration
  • Prior adverse drug reaction or therapeutic failure
Reflex

CYP3A5 Genotyping

Sample:
2 mL EDTA Whole Blood
TAT:
5–7 Business Days

$250

Test factsheet

Genotyping of CYP3A5 for tacrolimus metabolism phenotype.

Sample requirements: 2 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 5–7 Business Days

May be considered for:

  • Tacrolimus dosing planned
  • Prior adverse drug reaction or therapeutic failure
  • Polypharmacy including immunosuppressants
Reflex

Opioid Pharmacogenomics Panel

Sample:
2 mL EDTA Whole Blood
TAT:
7–10 Business Days

$450

Test factsheet

Combined pharmacogenomic profile for opioid efficacy and metabolism.

Sample requirements: 2 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 7–10 Business Days

May be considered for:

  • Chronic opioid therapy planning
  • Prior inadequate analgesia or unusual opioid sensitivity
  • Pre-operative pain management planning
  • Prior adverse drug reaction or therapeutic failure

Clinical testing guide

This cluster covers pharmacogenomic panels used to support prescribing decisions. Testing is usually considered when a medication has a known gene–drug interaction or when prior adverse effects raise a question; reports are written for prescribers and reviewed with a counselor before release.

Choosing between a panel and a single-marker test

Tests in this group answer different clinical questions. A focused single-marker or small-panel assay is usually the right starting point when the clinical question is specific; multi-gene or multi-marker panels fit when several conditions remain possible. First line assays are the usual entry point, reflex assays follow up on first-line findings, and confirmatory genetics settles an open question. Your genetic counselor confirms the right starting point against your history and prescription before anything is booked.

Before sample collection

  • Fasting: most genetic tests do not require fasting — follow the instructions on your kit insert.
  • Tube types: the required tube and volume are listed per test above (e.g. EDTA, sodium citrate, Streck).
  • Medication & anticoagulants: tell your counselor about anticoagulants, immunosuppressants or recent transfusions before the draw — never stop prescribed medication without your prescriber's advice.

Questions before booking

Should I start with a multi-gene panel or a single-marker test? ▾

A focused single-marker or small-panel assay is usually the right first step when the clinical question is specific; multi-gene or multi-marker panels fit when several conditions remain possible. Your genetic counselor reviews your history and prescription before booking to confirm the starting point, and reflex or confirmatory testing is only added when the clinical picture requires it.

Does insurance, Medicare, Medicaid or HSA/FSA cover this testing? ▾

Coverage depends on medical necessity and your plan. We support private insurance, Medicare and Medicaid billing, and self-pay by card or HSA/FSA. On request we provide CPT codes and a medical-necessity letter so your payer can complete pre-authorization before collection — final coverage decisions rest with your payer.

Can the sample be collected near me or at home? ▾

Yes. We arrange collection at patient service centers nationwide and, for eligible tests, at home through mobile phlebotomy. Your counselor confirms the correct tube, volume and any preparation instructions when the booking is verified.

Do I need a prescription or genetic counseling before testing? ▾

A clinician's order is required for most assays and always recommended. Pre-test genetic counselor guidance is included with every booking — we verify the indication, explain what the results can and cannot show, and coordinate reporting back to your care team.

Price (USD)
Turnaround
Sample

Patient preparation:

May be considered for: