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Hereditary Breast & Ovarian Cancer Testing

BRCA1 · BRCA2 · PALB2 · TP53 · CHEK2

Genetic results require clinical confirmation and are interpreted together with your medical and family history. A qualified healthcare provider confirms any diagnosis — our counselors help you pick the right assay before you book.

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Medically reviewed by Dr. Robert Vance, MD, FACMG (Chief Medical Geneticist)

  • CLIA-Certified & CAP-Accredited
  • HIPAA-Compliant Quality System
  • Free Pre-Test Genetic Counselor Guidance
  • Nationwide & At-Home Sample Collection
9 tests in Hereditary Breast & Ovarian Cancer All tests A–Z →
First line

BRCA1/BRCA2 Panel

Sample:
3 mL EDTA Whole Blood
TAT:
10–14 Business Days

$450

Test factsheet

Comprehensive BRCA1 and BRCA2 gene analysis for hereditary breast and ovarian cancer risk.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: Follow the instructions on your collection kit.

Turnaround notes: 10-14 business days from sample receipt. Same-week collection available at most patient service centers.

May be considered for:

  • Early-onset breast cancer (age ≤ 50)
  • Triple-negative breast cancer
  • Ovarian, fallopian tube, or primary peritoneal cancer
  • Male breast cancer
  • Known familial BRCA1/BRCA2, PALB2, TP53, or CHEK2 pathogenic variant
Confirmatory genetics

Hereditary Cancer Panel - Extended

Sample:
3 mL EDTA Whole Blood
TAT:
14–21 Business Days

$1,250

Test factsheet

Multi-gene panel covering 30+ cancer susceptibility genes.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: Follow the instructions on your collection kit.

Turnaround notes: 14-21 business days from sample receipt; parental samples may extend interpretation time.

May be considered for:

  • Family history spanning multiple hereditary cancer syndromes
  • Negative focused panel with persistent clinical suspicion
  • Colorectal or endometrial cancer at age ≤ 50
  • Two or more related primary cancers in one individual
First line

PALB2 Single-Gene Sequencing

Sample:
3 mL EDTA Whole Blood
TAT:
10–14 Business Days

$450

Test factsheet

Sequencing and deletion/duplication analysis of PALB2 for hereditary breast and pancreatic cancer risk.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 10–14 Business Days

May be considered for:

  • Early-onset breast cancer (age ≤ 50)
  • Triple-negative breast cancer
  • Family history of pancreatic cancer
  • Known familial PALB2 pathogenic variant
First line

TP53 (Li-Fraumeni) Single-Gene Sequencing

Sample:
3 mL EDTA Whole Blood
TAT:
10–14 Business Days

$550

Test factsheet

Full TP53 sequencing with deletion analysis for Li-Fraumeni syndrome.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 10–14 Business Days

May be considered for:

  • Childhood-onset sarcoma or adrenocortical carcinoma
  • Multiple primary cancers at young ages
  • Early-onset breast cancer (age ≤ 50)
  • Known familial TP53 pathogenic variant
First line

CHEK2 Single-Gene Sequencing

Sample:
3 mL EDTA Whole Blood
TAT:
10–14 Business Days

$450

Test factsheet

Sequencing and deletion/duplication analysis of CHEK2.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 10–14 Business Days

May be considered for:

  • Early-onset breast cancer (age ≤ 50)
  • Triple-negative breast cancer
  • Family history of colorectal or prostate cancer
  • Known familial CHEK2 pathogenic variant
Reflex

ATM Single-Gene Sequencing

Sample:
3 mL EDTA Whole Blood
TAT:
10–14 Business Days

$450

Test factsheet

Full ATM sequencing with deletion/duplication analysis.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 10–14 Business Days

May be considered for:

  • Early-onset breast cancer (age ≤ 50)
  • Ovarian, fallopian tube, or primary peritoneal cancer
  • Heterozygous ATM finding on a prior panel
  • Known familial ATM pathogenic variant
First line

BRCA1/2 Ashkenazi Jewish Founder Mutation Panel

Sample:
3 mL EDTA Whole Blood
TAT:
5–7 Business Days

$250

Test factsheet

Rapid targeted genotyping of the three Ashkenazi Jewish BRCA1/BRCA2 founder mutations.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 5–7 Business Days

May be considered for:

  • Ashkenazi Jewish ancestry
  • Early-onset breast cancer (age ≤ 50)
  • Ovarian, fallopian tube, or primary peritoneal cancer
  • Male breast cancer
Reflex

BRCA1/2 Large Rearrangement (MLPA) Reflex

Sample:
3 mL EDTA Whole Blood
TAT:
7–10 Business Days

$350

Test factsheet

MLPA-based detection of large genomic rearrangements in BRCA1 and BRCA2.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: Reflexed automatically after negative BRCA1/2 sequencing when clinical suspicion remains high.

May be considered for:

  • Negative BRCA1/2 sequencing with strong family history
  • Known large rearrangement in the family
  • Early-onset breast cancer (age ≤ 50)
  • Ovarian, fallopian tube, or primary peritoneal cancer
First line

High-Risk Breast Cancer 7-Gene Panel

Sample:
3 mL EDTA Whole Blood
TAT:
14–21 Business Days

$850

Test factsheet

Focused seven-gene panel covering the highest-penetrance hereditary breast cancer genes.

Sample requirements: 3 mL EDTA Whole Blood

Patient preparation: No fasting required unless your kit insert says otherwise. Bring a photo ID and, when applicable, the clinician order and insurance card.

Turnaround notes: 14–21 Business Days

May be considered for:

  • Early-onset breast cancer (age ≤ 50)
  • Triple-negative breast cancer
  • Ovarian, fallopian tube, or primary peritoneal cancer
  • Male breast cancer
  • Known familial BRCA1/BRCA2, PALB2, TP53, or CHEK2 pathogenic variant

Clinical testing guide

This cluster covers the assays used when a personal or family history raises a hereditary breast or ovarian cancer question. Focused first-line testing is usually the right starting point; broader genomic panels are generally reserved for cases where first-line results do not explain the family history. Our counselors verify the prescription and indication before booking.

Choosing between a panel and a single-marker test

Tests in this group answer different clinical questions. A focused single-marker or small-panel assay is usually the right starting point when the clinical question is specific; multi-gene or multi-marker panels fit when several conditions remain possible. First line assays are the usual entry point, reflex assays follow up on first-line findings, and confirmatory genetics settles an open question. Your genetic counselor confirms the right starting point against your history and prescription before anything is booked.

Before sample collection

  • Fasting: most genetic tests do not require fasting — follow the instructions on your kit insert.
  • Tube types: the required tube and volume are listed per test above (e.g. EDTA, sodium citrate, Streck).
  • Medication & anticoagulants: tell your counselor about anticoagulants, immunosuppressants or recent transfusions before the draw — never stop prescribed medication without your prescriber's advice.

Questions before booking

Should I start with a multi-gene panel or a single-marker test? ▾

A focused single-marker or small-panel assay is usually the right first step when the clinical question is specific; multi-gene or multi-marker panels fit when several conditions remain possible. Your genetic counselor reviews your history and prescription before booking to confirm the starting point, and reflex or confirmatory testing is only added when the clinical picture requires it.

Does insurance, Medicare, Medicaid or HSA/FSA cover this testing? ▾

Coverage depends on medical necessity and your plan. We support private insurance, Medicare and Medicaid billing, and self-pay by card or HSA/FSA. On request we provide CPT codes and a medical-necessity letter so your payer can complete pre-authorization before collection — final coverage decisions rest with your payer.

Can the sample be collected near me or at home? ▾

Yes. We arrange collection at patient service centers nationwide and, for eligible tests, at home through mobile phlebotomy. Your counselor confirms the correct tube, volume and any preparation instructions when the booking is verified.

Do I need a prescription or genetic counseling before testing? ▾

A clinician's order is required for most assays and always recommended. Pre-test genetic counselor guidance is included with every booking — we verify the indication, explain what the results can and cannot show, and coordinate reporting back to your care team.

Price (USD)
Turnaround
Sample

Patient preparation:

May be considered for: