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FISH t(15;17) or LSI PML-RARA Test

Original price was: $188.Current price is: $150.

-20%

The FISH t(15;17) or LSI PML-RARA Test is a specialized cytogenetic analysis that detects the specific chromosomal translocation associated with Acute Promyelocytic Leukemia (APL). This diagnostic test identifies the fusion of PML and RARA genes on chromosomes 15 and 17, which is crucial for accurate APL diagnosis and treatment planning. The test is essential for patients showing symptoms of acute leukemia, including unexplained bruising, bleeding tendencies, fatigue, and abnormal blood counts. Results are typically available within 4 working days, providing critical information for oncologists to determine appropriate targeted therapy options. The test is priced at $150 USD (discounted from $188 USD) and requires specific sample collection from blood or bone marrow with proper documentation.

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FISH t(15;17) or LSI PML-RARA Test

Comprehensive Diagnostic Testing for Acute Promyelocytic Leukemia

The FISH t(15;17) or LSI PML-RARA Test represents a critical advancement in molecular diagnostics for hematological malignancies. This specialized fluorescence in situ hybridization (FISH) test specifically targets the chromosomal translocation between chromosomes 15 and 17, which results in the fusion of the PML (Promyelocytic Leukemia) and RARA (Retinoic Acid Receptor Alpha) genes. This genetic abnormality is the hallmark of Acute Promyelocytic Leukemia (APL), a distinct subtype of acute myeloid leukemia that requires specific therapeutic approaches.

What This Test Measures and Detects

The FISH t(15;17) or LSI PML-RARA Test utilizes advanced molecular cytogenetic techniques to identify the specific genetic rearrangement that characterizes APL:

  • Detection of the t(15;17) chromosomal translocation
  • Identification of PML-RARA gene fusion
  • Assessment of genetic abnormalities in blood or bone marrow cells
  • Confirmation of Acute Promyelocytic Leukemia diagnosis
  • Monitoring of treatment response in APL patients

Who Should Consider This Test

This specialized diagnostic test is recommended for individuals presenting with symptoms suggestive of acute leukemia, particularly:

  • Patients with unexplained bruising or bleeding tendencies
  • Individuals experiencing persistent fatigue and weakness
  • Those with recurrent infections and fever
  • Patients showing abnormal complete blood count results
  • Individuals with bone pain or joint discomfort
  • Patients with swollen lymph nodes or enlarged spleen
  • Those with night sweats and unexplained weight loss

Clinical Benefits of the FISH PML-RARA Test

Undergoing this specialized diagnostic procedure offers numerous advantages for patients and healthcare providers:

  • Accurate Diagnosis: Provides definitive confirmation of Acute Promyelocytic Leukemia
  • Targeted Treatment Planning: Guides the use of specific therapies like all-trans retinoic acid (ATRA)
  • Prognostic Information: Helps determine disease severity and expected outcomes
  • Treatment Monitoring: Allows assessment of treatment effectiveness
  • Minimal Residual Disease Detection: Identifies low levels of remaining leukemia cells
  • Personalized Care: Enables tailored treatment approaches based on genetic findings

Understanding Your Test Results

Interpreting FISH t(15;17) or LSI PML-RARA Test results requires specialized medical expertise:

  • Positive Result: Indicates presence of PML-RARA gene fusion, confirming APL diagnosis
  • Negative Result: Suggests absence of the specific translocation, though other leukemia types may still be present
  • Quantitative Analysis: Provides information about the percentage of cells carrying the abnormality
  • Clinical Correlation: Results should be interpreted alongside other laboratory findings and clinical presentation
  • Follow-up Recommendations: Your hematologist or oncologist will discuss appropriate next steps based on results

Test Pricing Information

Price Type Amount (USD)
Discount Price $150
Regular Price $188

Test Specifications and Requirements

Turnaround Time: Sample accepted daily by 4 pm; Results available in 4 working days

Sample Requirements: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes

Shipping Instructions: Ship at 18-22°C. DO NOT FREEZE

Mandatory Documentation: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is required

Nationwide Accessibility

We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee.

Take Action for Your Health

Don’t delay in obtaining the critical diagnostic information you need. The FISH t(15;17) or LSI PML-RARA Test provides essential genetic insights that can significantly impact your treatment journey and overall outcomes. Our team of specialized cytogeneticists and hematology experts are ready to assist you with comprehensive testing and personalized care.

Book your test today by calling or WhatsApp: +1(267) 388-9828

Our dedicated patient care coordinators are available to answer your questions, schedule appointments, and guide you through the testing process. Early and accurate diagnosis is crucial for effective management of hematological conditions, and our advanced FISH testing capabilities ensure you receive the most reliable results available.

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