Extractable Nuclear Antigens ENA Anti-Nuclear Antibodies ANA Qualitative Profile Test
Comprehensive Autoimmune Disease Screening
The Extractable Nuclear Antigens (ENA) Anti-Nuclear Antibodies (ANA) Qualitative Profile Test represents a sophisticated diagnostic tool in modern immunopathology. This comprehensive screening panel utilizes advanced immunoblot technology to detect antibodies against 15 different nuclear antigens, providing clinicians with critical information for diagnosing and managing autoimmune disorders. As autoimmune conditions affect millions of Americans, this test serves as an essential component in the early detection and differentiation of complex rheumatic diseases.
What Does This Test Measure?
This specialized immunoblot test detects and identifies specific autoantibodies directed against extractable nuclear antigens, including:
- Anti-Sm antibodies (specific for systemic lupus erythematosus)
- Anti-RNP antibodies (associated with mixed connective tissue disease)
- Anti-SSA/Ro and Anti-SSB/La antibodies (linked to Sjogren’s syndrome)
- Anti-Scl-70 antibodies (indicative of scleroderma)
- Anti-Jo-1 antibodies (associated with polymyositis and dermatomyositis)
- Anti-centromere antibodies (characteristic of limited scleroderma)
The test provides qualitative detection of these 15 key autoantibodies, offering a comprehensive profile that helps differentiate between various autoimmune conditions with overlapping clinical presentations.
Who Should Consider This Test?
This test is particularly valuable for individuals experiencing symptoms suggestive of autoimmune disorders, including:
- Unexplained joint pain, swelling, or stiffness
- Persistent fatigue and malaise
- Skin rashes, particularly photosensitive rashes
- Muscle weakness or pain
- Dry eyes and dry mouth (sicca symptoms)
- Raynaud’s phenomenon (color changes in fingers with cold exposure)
- Unexplained fever or weight loss
- Positive ANA screening test requiring further characterization
Patients with family histories of autoimmune diseases or those being evaluated by rheumatologists for suspected connective tissue disorders are ideal candidates for this comprehensive screening.
Benefits of ENA ANA Qualitative Profile Testing
- Early Diagnosis: Enables early detection of autoimmune conditions before irreversible tissue damage occurs
- Disease Differentiation: Helps distinguish between different autoimmune disorders with similar symptoms
- Treatment Guidance: Provides information that guides targeted treatment strategies
- Prognostic Value: Certain antibody patterns correlate with disease severity and progression
- Comprehensive Screening: Single test screens for 15 different autoantibodies
- Same-Day Results: Rapid turnaround with reports available the same day when samples are submitted by 9 AM
- No Special Preparation: Convenient testing with no fasting or special preparation required
Understanding Your Test Results
Your ENA ANA Qualitative Profile results will indicate the presence or absence of specific autoantibodies. A positive result for particular antibodies suggests specific autoimmune conditions:
- Anti-Sm positive: Highly specific for systemic lupus erythematosus (SLE)
- Anti-RNP positive: Suggests mixed connective tissue disease
- Anti-SSA/Ro positive: Associated with Sjogren’s syndrome and subacute cutaneous lupus
- Anti-Scl-70 positive: Indicates systemic sclerosis (scleroderma)
- Anti-Jo-1 positive: Suggests inflammatory myopathies
It’s important to note that test results should always be interpreted by your healthcare provider in the context of your clinical symptoms, medical history, and other laboratory findings. Some individuals may have positive antibodies without clinical disease, while others with autoimmune conditions may have negative results.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $188 |
| Regular Price | $238 |
Nationwide Testing Network
We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our extensive network ensures accessible autoimmune testing for patients throughout the country.
Book Your Test Today
Take control of your health with comprehensive autoimmune screening. Our ENA ANA Qualitative Profile Test provides valuable insights for early detection and management of autoimmune conditions. With same-day results and no special preparation required, getting tested has never been more convenient.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your test or speak with our healthcare specialists about your testing needs.
Note: This test requires a 2 mL serum sample (minimum 1 mL) collected in an SST tube. Samples should be shipped refrigerated or frozen. Testing is available Monday through Saturday with same-day reporting when samples are received by 9 AM.
