Endomysial Antibody IgA IFA in Dilutions Test
Understanding the Endomysial Antibody Test
The Endomysial Antibody IgA IFA in Dilutions Test represents a cornerstone in autoimmune gastrointestinal diagnostics, specifically designed to detect celiac disease with exceptional accuracy. This sophisticated immunofluorescence assay identifies IgA-class antibodies that target the endomysium—the connective tissue surrounding muscle fibers in the small intestine. When these antibodies are present, they indicate an autoimmune response to gluten, making this test invaluable for diagnosing gluten-sensitive enteropathy and related conditions.
What Does This Test Measure?
This specialized diagnostic test detects and quantifies IgA antibodies directed against endomysial antigens, primarily tissue transglutaminase (tTG). The test utilizes immunofluorescence technology to visualize antibody binding patterns in various dilutions, providing:
- Detection of autoimmune response to gluten proteins
- Quantification of antibody levels through serial dilutions
- Assessment of intestinal mucosal immune activity
- Identification of celiac disease-specific antibody patterns
Who Should Consider This Test?
This test is recommended for individuals experiencing symptoms suggestive of celiac disease or gluten sensitivity. Key indications include:
Symptoms and Clinical Presentations
- Chronic diarrhea or constipation lasting more than 4 weeks
- Unexplained weight loss despite adequate calorie intake
- Abdominal bloating, pain, or discomfort after meals
- Iron-deficiency anemia unresponsive to iron supplementation
- Fatigue, weakness, or general malaise
- Dermatitis herpetiformis (skin rash associated with celiac disease)
- Dental enamel defects or recurrent mouth ulcers
- Elevated liver enzymes without clear cause
- Family history of celiac disease or autoimmune disorders
Benefits of Endomysial Antibody Testing
Choosing the Endomysial Antibody IgA IFA in Dilutions Test offers numerous advantages for comprehensive gastrointestinal health assessment:
Diagnostic Precision
- High specificity for celiac disease diagnosis (over 95%)
- Excellent correlation with intestinal biopsy findings
- Ability to monitor disease activity and dietary compliance
- Early detection of subclinical or silent celiac disease
Clinical Management Advantages
- Guides appropriate gluten-free diet implementation
- Helps prevent long-term complications like osteoporosis
- Supports nutritional deficiency identification and management
- Facilitates screening of at-risk family members
Understanding Your Test Results
Interpreting Endomysial Antibody results requires professional medical expertise, but general guidance includes:
Positive Results
A positive test indicates the presence of IgA antibodies against endomysial antigens, strongly suggesting active celiac disease. The dilution level at which antibodies remain detectable provides information about antibody concentration and disease activity. Higher titers typically correlate with more extensive intestinal damage.
Negative Results
Negative results generally rule out active celiac disease with high probability. However, false negatives can occur in individuals with selective IgA deficiency, requiring additional testing with IgG-based assays in such cases.
Borderline or Equivocal Results
Intermediate results may warrant repeat testing, additional serological markers, or consideration of small intestinal biopsy for definitive diagnosis.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Endomysial Antibody IgA IFA in Dilutions Test | $126 USD | $188 USD |
Testing Process Details
- Sample Type: 3 mL (1.5 mL minimum) serum from 1 SST tube
- Shipping Requirements: Refrigerated or frozen transport
- Turnaround Time: Sample accepted daily by 11 AM, results next day
- Pre-test Instructions: Overnight fasting is preferred for optimal results
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, with specialized centers in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures convenient access to advanced diagnostic services regardless of your location.
Book Your Test Today
Take control of your gastrointestinal health with our specialized Endomysial Antibody testing. Our expert team of gastroenterologists and immunopathology specialists are ready to provide comprehensive care and accurate diagnosis.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your appointment or discuss your testing needs with our medical professionals.
Early detection and proper management of celiac disease can significantly improve quality of life and prevent serious complications. Trust GGC DNA for reliable, accurate diagnostic testing backed by cutting-edge technology and medical expertise.
