XIAP Gene Lymphoproliferative Syndrome X-Linked Type 2 NGS Genetic DNA Test
Comprehensive Genetic Testing for Immune System Disorders
The XIAP Gene Lymphoproliferative Syndrome X-Linked Type 2 NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for inherited immune deficiencies. This sophisticated genetic analysis utilizes next-generation sequencing (NGS) technology to identify mutations in the XIAP (X-linked inhibitor of apoptosis) gene, which plays a critical role in regulating programmed cell death and immune system function.
What Does This Test Measure?
This advanced genetic test specifically targets and sequences the entire XIAP gene to detect:
- Point mutations, deletions, and insertions in the XIAP gene
- Genetic variants associated with X-linked lymphoproliferative syndrome type 2 (XLP-2)
- Mutations that disrupt normal apoptosis regulation and immune cell function
- Inherited genetic changes that increase susceptibility to hemophagocytic lymphohistiocytosis (HLH)
Who Should Consider This Test?
This genetic test is recommended for individuals presenting with:
- Unexplained recurrent fevers and systemic inflammation
- Enlarged spleen (splenomegaly) or liver (hepatomegaly)
- Abnormal blood cell counts, particularly cytopenias
- History of severe Epstein-Barr virus (EBV) infections
- Family history of immune disorders or early childhood deaths
- Suspected hemophagocytic lymphohistiocytosis (HLH)
- Male relatives of individuals with confirmed XIAP mutations
Clinical Benefits of XIAP Genetic Testing
Early genetic diagnosis through this test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms XLP-2 and differentiates from other immune deficiencies
- Personalized Treatment: Guides targeted therapies and hematopoietic stem cell transplantation decisions
- Family Planning: Enables genetic counseling and carrier testing for at-risk relatives
- Proactive Monitoring: Allows for early intervention before life-threatening complications develop
- Improved Outcomes: Early diagnosis significantly improves survival rates and quality of life
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our expert geneticists and hematologists:
- Positive Result: Identifies a pathogenic mutation in the XIAP gene, confirming XLP-2 diagnosis
- Negative Result: No disease-causing mutations detected, though clinical follow-up may still be recommended
- Variant of Uncertain Significance (VUS): Identifies genetic changes with unknown clinical impact requiring further evaluation
- Carrier Status: For female relatives, identifies if they carry the mutation and risk passing it to offspring
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | XIAP Gene Lymphoproliferative Syndrome X-Linked Type 2 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before scheduling your test, please ensure:
- Complete clinical history documentation for the patient
- Genetic counseling session to create a detailed family pedigree chart
- Identification of family members affected by similar symptoms
- Discussion of test implications and potential outcomes with healthcare provider
Nationwide Testing Availability
We proudly offer this specialized genetic testing across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more cities. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of your location.
Take Control of Your Genetic Health Today
Don’t wait to get answers about potential genetic immune disorders. Our expert team of genetic counselors and hematologists are ready to guide you through the testing process and help interpret your results. Early detection of XIAP gene mutations can be life-saving and significantly improve long-term health outcomes.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic test consultation and take the first step toward understanding your genetic health.
Our compassionate healthcare professionals understand the emotional journey of genetic testing and are committed to providing supportive, comprehensive care throughout your diagnostic process. Book your appointment now and gain the clarity you need for informed healthcare decisions.
