INF2 Gene Focal Segmental Glomerulosclerosis Type 5 NGS Genetic DNA Test
Comprehensive Genetic Testing for Hereditary Kidney Disease
The INF2 Gene Focal Segmental Glomerulosclerosis Type 5 NGS Genetic DNA Test represents a breakthrough in precision medicine for individuals at risk of hereditary kidney disorders. This advanced diagnostic tool utilizes next-generation sequencing technology to analyze the INF2 (inverted formin 2) gene, which plays a critical role in maintaining the structural integrity of kidney filtration units. Mutations in this gene are directly linked to the development of focal segmental glomerulosclerosis type 5, a progressive kidney condition that can lead to end-stage renal disease if left undiagnosed.
What This Test Measures and Detects
Our comprehensive NGS-based analysis examines the entire coding region of the INF2 gene to identify pathogenic variants, including:
- Missense mutations affecting protein function
- Nonsense mutations leading to premature stop codons
- Frameshift mutations disrupting gene reading frames
- Splice site variants affecting RNA processing
- Small insertions and deletions impacting gene structure
The test provides detailed information about specific genetic alterations that compromise the actin cytoskeleton dynamics in podocytes – specialized cells essential for proper kidney filtration.
Who Should Consider This Genetic Test
This test is particularly recommended for individuals experiencing:
- Unexplained proteinuria or albuminuria
- Family history of kidney disease or renal failure
- Early-onset hypertension with renal involvement
- Progressive decline in kidney function without clear cause
- Diagnosis of FSGS without identified secondary causes
- Family members of individuals with confirmed INF2 mutations
- Children or young adults with nephrotic syndrome
- Individuals with steroid-resistant nephrotic syndrome
Significant Benefits of INF2 Genetic Testing
Undergoing INF2 gene testing provides numerous advantages for patients and healthcare providers:
- Early Intervention Opportunities: Identify at-risk individuals before significant kidney damage occurs
- Personalized Treatment Plans: Tailor therapeutic approaches based on genetic findings
- Family Planning Guidance: Understand inheritance patterns and recurrence risks
- Prognostic Information: Gain insights into disease progression and potential outcomes
- Reduced Diagnostic Uncertainty: Provide definitive answers for complex renal presentations
- Targeted Monitoring: Implement appropriate surveillance strategies for mutation carriers
Understanding Your Test Results
Our comprehensive genetic counseling service helps you interpret your results effectively:
- Positive Result: Indicates the presence of a pathogenic INF2 mutation. This confirms the genetic basis of kidney symptoms and enables targeted management strategies.
- Negative Result: Suggests that INF2 mutations are not responsible for the kidney condition, guiding further diagnostic evaluation.
- Variant of Uncertain Significance: Identifies genetic changes with unclear clinical implications, requiring ongoing research and family studies.
All results are accompanied by detailed explanations and recommendations from our certified genetic counselors.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Turnaround Time: 3 to 4 weeks
Sample Type: Blood, Extracted DNA, or One drop Blood on FTA Card
Nationwide Testing Availability
We have conveniently located testing centers across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure consistent, high-quality testing standards nationwide.
Take Control of Your Kidney Health Today
Don’t let uncertainty about hereditary kidney conditions affect your quality of life. Our INF2 Gene Focal Segmental Glomerulosclerosis Type 5 NGS Genetic DNA Test provides the clarity you need for informed healthcare decisions. Schedule your appointment today and take the first step toward understanding your genetic risk factors.
Call or WhatsApp us at +1(267) 388-9828 to book your test or speak with our genetic counseling team. Our specialists are available to answer your questions and guide you through the testing process with compassion and expertise.
