ALOXE3 Gene Ichthyosiform Erythroderma Congenital Nonbullous Type 1 NGS Genetic DNA Test
Comprehensive Genetic Testing for Inherited Skin Disorders
The ALOXE3 Gene Ichthyosiform Erythroderma Congenital Nonbullous Type 1 NGS Genetic DNA Test represents a breakthrough in dermatological genetic diagnostics. This specialized test utilizes advanced next-generation sequencing (NGS) technology to identify mutations in the ALOXE3 gene, which plays a crucial role in maintaining healthy skin barrier function. Congenital ichthyosiform erythroderma is a rare inherited condition characterized by widespread skin inflammation, scaling, and redness present from birth.
What Does This Test Measure?
Our comprehensive genetic analysis specifically targets the ALOXE3 gene, which encodes arachidonate lipoxygenase 3 enzyme essential for proper skin development and maintenance. The test detects:
- Pathogenic variants in the ALOXE3 gene associated with congenital ichthyosiform erythroderma
- Single nucleotide polymorphisms (SNPs) affecting enzyme function
- Deletion and insertion mutations disrupting gene expression
- Compound heterozygous mutations causing autosomal recessive inheritance patterns
Who Should Consider This Test?
This genetic test is recommended for individuals presenting with:
- Persistent generalized skin redness and scaling from birth
- Family history of congenital ichthyosiform erythroderma
- Unexplained erythroderma in infancy or childhood
- Consanguineous parents with suspected autosomal recessive inheritance
- Previous inconclusive dermatological evaluations
- Planning for family with known ichthyosis history
Clinical Benefits of Genetic Testing
Undergoing the ALOXE3 gene test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms or rules out congenital ichthyosiform erythroderma with precision
- Personalized Treatment: Enables targeted therapeutic approaches based on genetic profile
- Family Planning: Provides crucial information for genetic counseling and reproductive decisions
- Early Intervention: Facilitates prompt management to improve quality of life
- Differential Diagnosis: Helps distinguish from other ichthyosis subtypes
- Prognostic Information: Offers insights into disease progression and management expectations
Understanding Your Test Results
Our comprehensive genetic report includes detailed interpretation of your results:
- Positive Result: Indicates presence of pathogenic ALOXE3 mutations confirming diagnosis
- Negative Result: Suggests absence of tested mutations but doesn’t exclude other genetic causes
- Variant of Uncertain Significance: Requires additional family studies for clarification
- Carrier Status: Identifies individuals with single mutation who may pass condition to offspring
All results are accompanied by professional genetic counseling to ensure complete understanding of implications for you and your family.
Test Pricing Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, reliable results regardless of your location.
Take Control of Your Genetic Health Today
Don’t let uncertainty about your genetic health prevent you from getting the answers you need. Our expert team of genetic counselors and dermatology specialists are ready to guide you through the testing process and help you understand your results. Early genetic diagnosis can significantly impact treatment outcomes and quality of life for individuals with congenital ichthyosiform erythroderma.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your ALOXE3 gene test. Take the first step toward understanding your genetic profile and making informed healthcare decisions for you and your family.
