ZIC3 Gene Heterotaxy Visceral Type 1 NGS Genetic DNA Test
Comprehensive Genetic Analysis for Organ Positioning Disorders
The ZIC3 Gene Heterotaxy Visceral Type 1 NGS Genetic DNA Test represents a cutting-edge diagnostic approach for identifying genetic mutations responsible for heterotaxy syndrome, a complex congenital condition characterized by abnormal organ positioning and development. This specialized test provides crucial insights into the genetic basis of visceral organ malposition, enabling accurate diagnosis and personalized treatment strategies for affected individuals and families.
What Does This Test Measure and Detect?
This advanced genetic test specifically targets the ZIC3 gene, which plays a critical role in establishing left-right asymmetry during embryonic development. The test utilizes Next-Generation Sequencing (NGS) technology to comprehensively analyze the entire ZIC3 gene sequence, detecting:
- Point mutations and single nucleotide variants
- Small insertions and deletions
- Missense, nonsense, and frameshift mutations
- Splice site variants affecting gene function
- Regulatory region abnormalities
The ZIC3 gene encodes a zinc finger protein that functions as a transcription factor essential for proper embryonic patterning and organ positioning. Mutations in this gene disrupt normal left-right axis determination, leading to heterotaxy syndrome characterized by randomized organ placement and associated congenital anomalies.
Who Should Consider This Genetic Test?
This test is recommended for individuals presenting with specific clinical features or family history patterns:
- Infants and children with congenital heart defects involving abnormal chamber positioning
- Patients with situs ambiguus or indeterminate organ positioning
- Individuals with complex cardiac anomalies including transposition of great arteries
- Patients with asplenia or polysplenia syndromes
- Families with history of heterotaxy or congenital heart disease
- Individuals with midline defects and organ malposition
- Patients undergoing evaluation for unexplained congenital anomalies
Clinical Benefits of ZIC3 Genetic Testing
Undergoing ZIC3 genetic testing provides numerous clinical advantages for patients and healthcare providers:
- Accurate Diagnosis: Confirms genetic etiology of heterotaxy syndrome
- Personalized Management: Guides appropriate medical and surgical interventions
- Family Planning: Provides recurrence risk information for future pregnancies
- Early Intervention: Enables proactive management of associated complications
- Comprehensive Care: Facilitates multidisciplinary approach to treatment
- Genetic Counseling: Supports informed decision-making for families
Understanding Your Test Results
Test results are carefully interpreted by our team of certified geneticists and molecular pathologists:
- Positive Result: Identifies a pathogenic mutation in the ZIC3 gene, confirming genetic diagnosis of heterotaxy visceral type 1
- Negative Result: No disease-causing mutation detected in ZIC3 gene; however, other genetic causes may be considered
- Variant of Uncertain Significance: Identifies genetic changes with unclear clinical implications requiring further evaluation
- Carrier Status: Determines if individuals carry ZIC3 mutations without showing symptoms
All results include comprehensive interpretation and clinical correlation to assist healthcare providers in developing appropriate management plans. Genetic counseling is recommended for all patients receiving positive results.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | ZIC3 Gene Heterotaxy Visceral Type 1 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before testing, we recommend:
- Complete clinical history documentation for patients undergoing ZIC3 testing
- Genetic counseling session to create detailed family pedigree chart
- Evaluation of family members affected by heterotaxy or related conditions
- Discussion of testing implications and potential outcomes
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network of certified collection centers ensures accessible testing for patients nationwide.
Take Action Today
Don’t wait to get the answers you need for proper diagnosis and management of heterotaxy syndrome. Our experienced genetic specialists are ready to assist you with comprehensive testing and personalized care.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your ZIC3 genetic test or to speak with our genetic counseling team. Early diagnosis can make a significant difference in treatment outcomes and quality of life.
