PMS2 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test
Comprehensive Genetic Testing for Hereditary Cancer Risk
The PMS2 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test represents a breakthrough in personalized cancer risk assessment. This advanced genetic test utilizes Next-Generation Sequencing (NGS) technology to analyze the PMS2 gene, a crucial component of the DNA mismatch repair system. When functioning properly, this system acts as a molecular proofreader, correcting errors that occur during DNA replication. Mutations in the PMS2 gene can lead to Lynch syndrome, a hereditary condition that significantly elevates the risk of developing various cancers throughout an individual’s lifetime.
What Does This Test Measure?
This sophisticated genetic analysis specifically targets the PMS2 gene to identify:
- Pathogenic mutations that disrupt DNA mismatch repair function
- Variants associated with Lynch syndrome inheritance patterns
- Genetic markers indicating increased cancer susceptibility
- Specific DNA sequence variations affecting protein function
- Inheritance patterns that may impact family members
Who Should Consider This Test?
This genetic test is particularly recommended for individuals who meet any of the following criteria:
- Personal history of colorectal cancer diagnosed before age 50
- Family history of Lynch syndrome-associated cancers
- Multiple first-degree relatives with colorectal or endometrial cancer
- Individuals with multiple primary Lynch-related cancers
- Those with a known family history of PMS2 gene mutations
- Patients with abnormal tumor testing suggesting mismatch repair deficiency
- Individuals seeking proactive cancer risk assessment
Key Benefits of PMS2 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Personalized Cancer Screening: Enables tailored surveillance protocols based on individual genetic risk
- Early Detection Opportunities: Facilitates proactive monitoring for at-risk individuals
- Family Risk Assessment: Provides valuable information for relatives who may also be at risk
- Informed Medical Decisions: Supports healthcare providers in developing personalized prevention strategies
- Psychological Relief: Reduces uncertainty through definitive genetic information
- Cost-Effective Prevention: Potentially reduces long-term healthcare costs through early intervention
Understanding Your Test Results
Your genetic test results will fall into one of several categories, each with specific implications:
- Positive Result: Indicates the presence of a pathogenic PMS2 mutation, confirming Lynch syndrome diagnosis and necessitating enhanced cancer surveillance
- Negative Result: No mutation detected in the PMS2 gene, though other genetic factors may still contribute to cancer risk
- Variant of Uncertain Significance (VUS): Identifies a genetic change with unknown clinical significance, requiring ongoing research and family studies
- Benign Variant: Common genetic variations not associated with increased cancer risk
All results should be interpreted in consultation with a genetic counselor or oncology specialist who can provide personalized recommendations based on your specific genetic findings and family history.
Test Pricing Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Test Specifications
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Technology: Next-Generation Sequencing (NGS)
- Specialty: Oncology Genetics
Pre-Test Requirements
Before undergoing testing, patients should provide:
- Complete clinical history relevant to cancer risk assessment
- Participation in genetic counseling session
- Detailed pedigree chart documenting family members affected by Lynch syndrome-associated cancers
- Informed consent acknowledging test implications and potential outcomes
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our network of certified genetic counselors and oncology specialists ensures comprehensive care regardless of your location.
Take Control of Your Genetic Health
Understanding your genetic predisposition to cancer can be life-changing. The PMS2 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test provides the clarity needed to make informed healthcare decisions and implement effective prevention strategies. Don’t leave your genetic health to chance – take proactive steps toward comprehensive cancer risk assessment today.
Ready to schedule your genetic test? Call or WhatsApp us at +1(267) 388-9828 to book your appointment and begin your journey toward personalized cancer prevention.
