HLA-B*57:01 Genotyping for Abacavir Hypersensitivity
Understanding HLA-B*57:01 Genetic Testing
The HLA-B*57:01 genotyping test represents a critical advancement in personalized medicine, specifically designed to identify individuals at risk for severe hypersensitivity reactions to abacavir, a cornerstone medication in HIV treatment regimens. This genetic screening test examines the human leukocyte antigen (HLA) system, which plays a fundamental role in immune system regulation and drug hypersensitivity responses.
What Does This Test Measure?
This specialized genetic test specifically detects the presence of the HLA-B*57:01 allele, a genetic variant strongly associated with abacavir hypersensitivity syndrome. The test utilizes sophisticated Sanger sequencing technology to analyze DNA samples obtained from peripheral blood, providing highly accurate results that guide critical treatment decisions for HIV-positive patients.
- Identifies HLA-B*57:01 genetic marker presence
- Uses advanced Sanger sequencing methodology
- Analyzes peripheral blood samples (EDTA Vacutainer 2ml)
- Provides definitive genetic risk assessment
Who Should Consider HLA-B*57:01 Testing?
This genetic screening is essential for specific patient populations to ensure medication safety and prevent severe adverse reactions.
Primary Candidates Include:
- HIV-positive individuals initiating antiretroviral therapy
- Patients being considered for abacavir-containing regimens
- Individuals with family history of drug hypersensitivity
- Patients requiring alternative HIV treatment options
- Those with previous adverse drug reactions
Clinical Benefits of HLA-B*57:01 Screening
Implementing HLA-B*57:01 genotyping before prescribing abacavir offers numerous clinical advantages that significantly improve patient safety and treatment outcomes.
Key Benefits:
- Prevents Severe Hypersensitivity Reactions: Identifies patients at risk before medication initiation
- Personalized Treatment Planning: Enables tailored HIV therapy selection
- Enhanced Medication Safety: Reduces risk of life-threatening allergic responses
- Cost-Effective Prevention: Avoids expensive emergency care for hypersensitivity reactions
- Improved Treatment Adherence: Ensures patients receive well-tolerated medications
Understanding Your Test Results
Proper interpretation of HLA-B*57:01 genotyping results is crucial for making informed treatment decisions and ensuring patient safety.
Result Interpretation Guidelines:
- Positive Result: Indicates presence of HLA-B*57:01 allele – Abacavir should be avoided due to high hypersensitivity risk
- Negative Result: No HLA-B*57:01 detected – Abacavir can be considered as treatment option with standard monitoring
- Clinical Consultation: All results should be discussed with healthcare providers for appropriate treatment planning
Test Pricing and Availability
| Test Description | Price (USD) |
|---|---|
| HLA-B*57:01 Genotyping for Abacavir Hypersensitivity – Discount Price | $100 |
| HLA-B*57:01 Genotyping for Abacavir Hypersensitivity – Regular Price | $188 |
Important Pre-Test Information
HLA-B*57:01 genotyping requires a doctor’s prescription for most cases. However, prescription requirements do not apply for surgical preparation, pregnancy-related testing, or international travel documentation purposes. Our testing process utilizes peripheral blood samples collected in EDTA Vacutainers (2ml) with results typically available within one week.
Nationwide Testing Availability
We maintain comprehensive testing facilities across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures accessible genetic testing services for patients nationwide.
Take Action for Your Health
Don’t leave your medication safety to chance. The HLA-B*57:01 genotyping test provides essential genetic information that can prevent serious adverse drug reactions and ensure optimal HIV treatment selection. Our experienced genetic counselors and healthcare professionals are ready to assist you with this important screening.
Book your HLA-B*57:01 genotyping test today by calling +1(267) 388-9828 or schedule your appointment online. Protect your health with personalized genetic screening and make informed treatment decisions with confidence.
