Comprehensive Hereditary Cancer Panel – 154 Genes
Understanding Hereditary Cancer Risk
Hereditary cancer syndromes account for approximately 5-10% of all cancer cases, representing a significant health concern that can be proactively managed through advanced genetic testing. Our Comprehensive Hereditary Cancer Panel represents the cutting edge of genetic cancer risk assessment, analyzing 154 genes known to be associated with inherited cancer predisposition. This comprehensive approach provides patients and healthcare providers with crucial information for developing personalized cancer prevention and early detection strategies.
What This Test Measures
The Comprehensive Hereditary Cancer Panel utilizes Next-Generation Sequencing (NGS) technology to analyze 154 genes associated with hereditary cancer syndromes. This includes:
- High-penetrance genes like BRCA1, BRCA2, TP53, and PTEN
- Moderate-penetrance genes associated with increased cancer risk
- Genes linked to multiple cancer types including breast, ovarian, colorectal, pancreatic, prostate, and melanoma
- Rare cancer susceptibility genes that may not be included in smaller panels
Technical Methodology
Our testing employs state-of-the-art NGS technology with comprehensive coverage of coding regions and flanking intronic sequences. All detected variants undergo rigorous clinical validation and interpretation according to ACMG/AMP guidelines, ensuring the highest standards of accuracy and reliability.
Who Should Consider This Test
This comprehensive genetic cancer panel is particularly valuable for individuals with:
- Personal history of cancer diagnosed at an early age
- Multiple primary cancers in the same individual
- Strong family history of cancer across multiple generations
- Known genetic mutations in the family
- Rare cancers or specific cancer types associated with hereditary syndromes
- Ashkenazi Jewish ancestry with increased BRCA mutation prevalence
- Concerns about passing cancer risk to children
Clinical Indications
Consider genetic testing if you have:
- Breast cancer diagnosed before age 50
- Triple-negative breast cancer at any age
- Ovarian cancer at any age
- Colorectal cancer diagnosed before age 50
- Pancreatic cancer with family history
- Prostate cancer with Gleason score ≥7 and family history
- Multiple relatives with the same or related cancers
Benefits of Comprehensive Genetic Cancer Testing
Undergoing comprehensive hereditary cancer testing provides numerous advantages for proactive health management:
- Personalized Risk Assessment: Understand your specific genetic cancer risks based on your unique genetic profile
- Enhanced Screening Protocols: Implement targeted surveillance strategies for early cancer detection
- Risk-Reduction Strategies: Consider preventive measures including medications or prophylactic surgeries
- Family Planning Guidance: Make informed decisions about family planning and genetic inheritance
- Peace of Mind: Reduce uncertainty about inherited cancer risk
- Family Member Testing: Identify at-risk relatives who may benefit from genetic testing
- Treatment Guidance: Inform treatment decisions for current cancer diagnoses
Understanding Your Test Results
Your comprehensive genetic cancer panel results will be carefully interpreted and categorized:
Positive Result
A positive result indicates the presence of a pathogenic or likely pathogenic variant in one of the cancer susceptibility genes. This information enables:
- Development of personalized cancer screening schedule
- Consideration of risk-reducing interventions
- Family testing and cascade screening
- Enhanced surveillance for associated cancers
Negative Result
A negative result means no pathogenic variants were detected in the genes analyzed. However, this does not eliminate cancer risk entirely, as:
- Other genetic factors not included in the panel may contribute to risk
- Environmental and lifestyle factors still play significant roles
- Standard cancer screening recommendations should still be followed
Variant of Uncertain Significance (VUS)
Some results may identify genetic changes with unclear clinical significance. These variants:
- Should not be used for medical management decisions
- May be reclassified as more information becomes available
- Do not typically change current medical recommendations
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | Comprehensive Hereditary Cancer Panel – 154 Genes |
| Regular Price | $1200 USD |
| Discount Price | $900 USD |
| Turnaround Time | 4-6 weeks |
| Sample Type | Peripheral Blood |
| Test Components | EDTA Vacutainer (2ml) |
| Testing Method | Next-Generation Sequencing (NGS) |
Pre-Test Requirements
The Comprehensive Hereditary Cancer Panel requires a Doctor’s prescription for testing. Please note that prescriptions are not applicable for surgery and pregnancy cases or individuals planning to travel abroad. Our genetic counselors are available to discuss testing implications and help facilitate the prescription process when needed.
Nationwide Accessibility
We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee. Our network ensures accessible genetic testing services regardless of your location.
Take Control of Your Genetic Health
Understanding your hereditary cancer risk is one of the most powerful steps you can take toward proactive health management. Our Comprehensive Hereditary Cancer Panel provides the detailed genetic information needed to make informed decisions about your healthcare journey. With results available in 4-6 weeks and comprehensive genetic counseling support, you’ll have the knowledge and resources to develop a personalized cancer prevention strategy.
Ready to Learn More About Your Genetic Cancer Risk?
Take the first step toward understanding your hereditary cancer risk. Our team of genetic specialists is ready to guide you through the testing process and help you interpret your results within the context of your personal and family medical history.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your Comprehensive Hereditary Cancer Panel test and begin your journey toward personalized cancer risk management.
