Immunohistochemistry Neuron Specific Enolase NSE Test
Comprehensive Diagnostic Testing for Neuroendocrine Tumors
The Immunohistochemistry Neuron Specific Enolase (NSE) Test represents a cornerstone in modern cancer diagnostics, providing critical insights into neuroendocrine tumors and neural tissue malignancies. This advanced immunohistochemical analysis detects the presence of neuron-specific enolase, an enzyme predominantly found in neurons and neuroendocrine cells, serving as a reliable biomarker for various cancers of neural origin.
What Does the NSE Test Measure?
The Immunohistochemistry NSE Test specifically identifies and quantifies the expression of neuron-specific enolase within tissue samples. NSE is a glycolytic enzyme that exists as a gamma-gamma dimer, primarily localized in neurons, neuroendocrine cells, and cells of neural crest origin. When these cells undergo malignant transformation, NSE expression patterns change significantly, making it an invaluable diagnostic marker.
- Detects NSE protein expression in tumor tissue samples
- Identifies neuroendocrine differentiation in various cancers
- Helps distinguish between different tumor types and origins
- Provides visual confirmation of biomarker presence through specialized staining techniques
Who Should Consider This Test?
This specialized diagnostic test is recommended for patients presenting with symptoms or clinical findings suggestive of neuroendocrine tumors or neural tissue malignancies. Key indications include:
- Patients with suspected small cell lung cancer based on imaging studies
- Individuals with symptoms of neuroendocrine tumors, including unexplained hormonal syndromes
- Patients with pancreatic masses suspicious for neuroendocrine tumors
- Children or adults with suspected neuroblastoma or other neural crest tumors
- Cases where tumor origin is unclear and neuroendocrine differentiation needs confirmation
- Patients with metastatic cancer of unknown primary origin
Clinical Benefits of NSE Testing
Undergoing the Immunohistochemistry NSE Test provides numerous clinical advantages for both patients and healthcare providers:
- Accurate Diagnosis: Confirms or rules out neuroendocrine tumor types with high specificity
- Treatment Guidance: Helps oncologists select appropriate targeted therapies and treatment protocols
- Prognostic Information: NSE expression levels can provide insights into disease aggressiveness and potential outcomes
- Differential Diagnosis: Distinguishes between different tumor types that may appear similar under routine microscopy
- Personalized Medicine: Enables tailored treatment approaches based on specific tumor characteristics
Understanding Your Test Results
Interpreting Immunohistochemistry NSE Test results requires specialized expertise from our board-certified pathologists. Results are typically reported as:
- Positive: Strong cytoplasmic staining indicates NSE expression, supporting neuroendocrine differentiation
- Negative: Absence of staining suggests the tumor is unlikely to be of neuroendocrine origin
- Focal Positive: Patchy staining may indicate partial neuroendocrine differentiation
- Intensity Scoring: Results may include staining intensity scores (0-3+) for quantitative assessment
It’s important to note that NSE positivity should be interpreted in the context of other clinical findings and additional immunohistochemical markers. Our pathology team provides comprehensive reports with detailed explanations and clinical correlations to ensure you fully understand your results.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry Neuron Specific Enolase NSE Test | $76 USD | $112 USD |
Turnaround Time and Sample Requirements
- Sample Collection: Daily by 6 PM
- Report Timeline: Tissue Block: 5 days | Tissue Biopsy: 5 days | Complex Tissue: 7 days
- Sample Type: Submit tumor tissue in 10% formal-saline OR formalin fixed paraffin embedded block
- Shipping: Ship at room temperature with proper documentation
- Required Documentation: Histopathology report, biopsy site information, and complete clinical history
Nationwide Accessibility
GGC DNA maintains comprehensive testing facilities across the United States, ensuring convenient access to the Immunohistochemistry NSE Test regardless of your location. Our network includes specialized centers in:
- New York City and surrounding metropolitan areas
- Los Angeles and Southern California regions
- Chicago and Midwest territories
- Houston and Texas Gulf Coast areas
- Phoenix and Southwest districts
- All other major metropolitan centers nationwide
Each facility operates under strict quality control standards and employs experienced pathology professionals dedicated to providing accurate, timely results.
Take Control of Your Health Today
Early and accurate diagnosis is crucial for effective cancer management. The Immunohistochemistry Neuron Specific Enolase NSE Test provides the critical information needed to make informed treatment decisions and optimize patient outcomes. Our team of oncology specialists and pathologists are committed to delivering exceptional diagnostic services with compassion and expertise.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Our dedicated patient coordinators are available to answer your questions and guide you through the testing process.
Don’t let uncertainty about your diagnosis delay necessary treatment. Trust GGC DNA for reliable, advanced cancer diagnostics that empower you and your healthcare team with the information needed for optimal care.
