PIK3CA Mutation Analysis Exon 7, 9 & 20
Comprehensive Genetic Testing for Personalized Cancer Treatment
The PIK3CA Mutation Analysis Exon 7, 9 & 20 represents a cutting-edge genetic test that provides crucial insights for cancer diagnosis and treatment planning. This specialized analysis focuses on detecting specific mutations in the PIK3CA gene, which encodes the p110α catalytic subunit of PI3K (phosphoinositide 3-kinase). The PI3K pathway is one of the most frequently altered signaling pathways in human cancers, making this test an essential tool for modern oncology practice.
What Does This Test Measure?
This comprehensive genetic analysis specifically targets mutations in exons 7, 9, and 20 of the PIK3CA gene using advanced Sanger sequencing technology. The test detects:
- Hotspot mutations in the helical domain (exon 9)
- Mutations in the kinase domain (exon 20)
- Additional relevant mutations in exon 7
- Specific amino acid changes that affect protein function
These mutations are particularly significant because they lead to constitutive activation of the PI3K pathway, promoting uncontrolled cell growth and survival – hallmarks of cancer development and progression.
Who Should Consider This Test?
This genetic analysis is recommended for patients with:
- Breast cancer, particularly hormone receptor-positive HER2-negative types
- Endometrial cancer and other gynecological malignancies
- Head and neck squamous cell carcinomas
- Colorectal cancers
- Patients being evaluated for PI3K inhibitor therapy
- Individuals with treatment-resistant cancers
- Patients seeking personalized treatment options
Clinical Benefits and Importance
Understanding PIK3CA mutation status provides numerous clinical advantages:
- Treatment Selection: Guides the use of targeted PI3K inhibitors like alpelisib
- Prognostic Information: Helps predict disease course and treatment response
- Personalized Medicine: Enables tailored treatment approaches based on genetic profile
- Clinical Trial Eligibility: Identifies patients suitable for targeted therapy trials
- Monitoring Treatment Response: Provides baseline for assessing therapy effectiveness
Understanding Your Test Results
Your test results will be carefully interpreted by our expert genetic counselors and oncologists:
- Positive Result: Indicates the presence of PIK3CA mutations, which may make you eligible for targeted therapies
- Negative Result: No detectable mutations were found in the analyzed exons
- Variant of Unknown Significance: Rare genetic changes whose clinical impact requires further study
All results include detailed interpretation and recommendations for next steps in your treatment journey. Our genetic counseling team is available to help you understand the implications of your results and discuss appropriate treatment options with your healthcare provider.
Test Pricing Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $226 |
| Regular Price | $300 |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network ensures that advanced genetic testing is accessible to patients nationwide.
Take the Next Step in Your Healthcare Journey
Don’t leave your treatment decisions to chance. The PIK3CA Mutation Analysis provides critical information that can significantly impact your cancer treatment outcomes. Our team of genetic specialists and oncology experts are ready to help you access this advanced testing and interpret your results within the clinical context of your specific condition.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Take control of your health with precision genetic testing that delivers actionable insights for your treatment plan.
Note: This test requires a doctor’s prescription for most cases. Prescription requirements do not apply to surgery and pregnancy cases or individuals planning international travel. Turnaround time for results is typically 7-8 days from sample receipt.
