Chronic Neutrophilic Leukemia CNL CSF3R Gene Exon 14 & 17 SETBP Gene Exon 4 Test
Understanding Chronic Neutrophilic Leukemia Genetic Testing
Chronic Neutrophilic Leukemia (CNL) is a rare and serious blood disorder characterized by the persistent overproduction of mature neutrophils in the bone marrow. Our specialized genetic test provides comprehensive analysis of key mutations in the CSF3R and SETBP genes, which are crucial for accurate diagnosis and treatment planning of this condition.
What This Test Measures and Detects
This advanced genetic screening specifically targets:
- CSF3R Gene Mutations: Analysis of exons 14 and 17 for colony-stimulating factor 3 receptor mutations
- SETBP Gene Mutations: Examination of exon 4 for SET binding protein gene abnormalities
- Specific genetic markers associated with CNL development and progression
- Mutation patterns that influence treatment response and prognosis
Who Should Consider This Genetic Test?
This test is recommended for individuals experiencing:
- Persistent elevated neutrophil counts in blood tests
- Unexplained fatigue and weakness
- Recurrent infections or fever
- Enlarged spleen (splenomegaly)
- Night sweats and unexplained weight loss
- Abnormal bleeding or bruising tendencies
- Family history of blood disorders or leukemia
Clinical Indications and Symptoms
Patients presenting with chronic neutrophilia, organomegaly, or constitutional symptoms should consider this test for definitive diagnosis. Early detection is crucial for implementing appropriate treatment strategies and improving long-term outcomes.
Benefits of Chronic Neutrophilic Leukemia Genetic Testing
- Accurate Diagnosis: Provides definitive confirmation of CNL through specific genetic markers
- Personalized Treatment: Guides targeted therapy selection based on mutation profile
- Prognostic Information: Helps predict disease progression and treatment response
- Early Intervention: Enables timely treatment initiation for better outcomes
- Family Risk Assessment: Provides information about potential hereditary factors
- Treatment Monitoring: Serves as baseline for tracking treatment effectiveness
Test Methodology and Technology
Our test utilizes advanced Sanger Sequencing technology, recognized as the gold standard for genetic mutation detection. This method provides:
- High accuracy and reliability in mutation detection
- Comprehensive coverage of targeted gene regions
- Clear identification of specific nucleotide changes
- Reliable results for clinical decision-making
Sample Requirements and Processing
Sample Type: Bone Marrow or Peripheral Blood
Container: EDTA Vacutainer (2ml)
Turnaround Time: 7-8 days
Methodology: Sanger Sequencing
Understanding Your Test Results
Your genetic test results will provide detailed information about:
- Mutation Status: Presence or absence of CSF3R and SETBP gene mutations
- Variant Classification
- Clinical Correlation: How identified mutations relate to CNL diagnosis
- Treatment Implications: Potential impact on therapy selection
- Follow-up Recommendations: Next steps based on your results
Interpreting Positive Results
Positive results indicate the presence of mutations associated with Chronic Neutrophilic Leukemia. These findings should be discussed with your hematologist or oncologist to develop an appropriate treatment plan.
Negative Results and Next Steps
Negative results suggest the absence of common CNL-associated mutations, but may require additional testing if clinical suspicion remains high. Your healthcare provider will guide further evaluation if needed.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $300 |
| Regular Price | $400 |
Nationwide Testing Availability
We have testing facilities conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our network ensures accessible genetic testing services for patients nationwide.
Pre-Test Instructions and Requirements
This test requires a doctor’s prescription for proper medical supervision. Prescription requirements do not apply to surgery and pregnancy cases or individuals planning international travel. Please consult with your healthcare provider to obtain the necessary referral.
Why Choose Our Genetic Testing Services?
- Expert analysis by board-certified genetic specialists
- State-of-the-art Sanger sequencing technology
- Comprehensive result interpretation and reporting
- Nationwide network of testing facilities
- Competitive pricing with insurance coordination
- Rapid 7-8 day turnaround time
Take Action for Your Health Today
Don’t wait to get the answers you need for proper diagnosis and treatment. Our Chronic Neutrophilic Leukemia genetic test provides the critical information required for effective disease management.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your test or speak with our genetic counseling team.
Early detection through comprehensive genetic testing can make a significant difference in treatment outcomes and quality of life. Take the first step toward understanding your condition and exploring appropriate treatment options.
