Von Willebrand Factor Ristocetin Cofactor Activity Test
Understanding the Von Willebrand Factor Ristocetin Cofactor Activity Test
The Von Willebrand Factor Ristocetin Cofactor Activity (vWF:RCo) test is a sophisticated diagnostic tool that plays a critical role in evaluating bleeding disorders and coagulation abnormalities. This specialized assessment measures the functional capacity of von Willebrand factor, a key protein in the blood clotting cascade that facilitates platelet adhesion to damaged blood vessel walls.
What Does This Test Measure?
The vWF:RCo test specifically evaluates the functional activity of von Willebrand factor by measuring its ability to bind to platelet glycoprotein Ib in the presence of ristocetin, an antibiotic that induces this interaction. This assessment provides crucial information about:
- Functional von Willebrand factor activity levels
- Platelet adhesion capability
- Overall coagulation efficiency
- Diagnostic classification of von Willebrand disease types
Who Should Consider This Test?
This test is recommended for individuals experiencing symptoms suggestive of bleeding disorders or those with known coagulation abnormalities. Key indications include:
Symptoms and Clinical Scenarios
- Unexplained or excessive bleeding following minor injuries
- Frequent nosebleeds without apparent cause
- Easy bruising with minimal trauma
- Heavy or prolonged menstrual bleeding in women
- Excessive bleeding after dental procedures or surgery
- Family history of bleeding disorders
- Monitoring treatment response in diagnosed von Willebrand disease
- Pre-operative screening for bleeding risk assessment
Benefits of the vWF:RCo Test
Choosing the Von Willebrand Factor Ristocetin Cofactor Activity test offers numerous advantages for comprehensive bleeding disorder evaluation:
Diagnostic Precision
- Accurate quantification of functional von Willebrand factor activity
- Differentiation between various types of von Willebrand disease
- Comprehensive assessment of platelet function capabilities
- Reliable monitoring of treatment effectiveness
Clinical Advantages
- Same-day results when samples are submitted by 11 AM
- Advanced chemiluminescent immunoassay methodology for superior accuracy
- Expert interpretation by hematology specialists
- Comprehensive bleeding risk assessment
Understanding Your Test Results
Interpreting vWF:RCo test results requires professional medical expertise, but general guidance includes:
Normal Results
Normal von Willebrand factor ristocetin cofactor activity typically ranges between 50-150% of normal plasma levels. Results within this range generally indicate adequate platelet adhesion function and normal von Willebrand factor activity.
Abnormal Results
- Decreased Activity: May indicate von Willebrand disease, with severity classification based on the degree of reduction
- Type 1 vWD: Mild to moderate reduction in activity levels
- Type 2 vWD: Disproportionate reduction compared to antigen levels
- Type 3 vWD: Severe deficiency or absence of activity
- Increased Activity: May occur in certain inflammatory conditions or pregnancy
Test Pricing and Availability
| Test Description | Price (USD) |
|---|---|
| Von Willebrand Factor Ristocetin Cofactor Activity Test | $450 |
| Discount Price | $326 |
Turnaround Time and Sample Requirements
- Turnaround: Same-day results when sample received by 11 AM
- Report Delivery: By 6 PM same day
- Sample Type: 3 mL whole blood in sodium citrate tube
- Special Instructions: Overnight fasting preferred, proper coagulation requisition form required
Nationwide Testing Availability
GGC DNA provides comprehensive Von Willebrand Factor Ristocetin Cofactor Activity testing services across the United States. Our state-of-the-art coagulation laboratories serve patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. With multiple collection centers nationwide, we ensure convenient access to advanced diagnostic testing.
Book Your Test Today
Take the first step toward understanding your bleeding risk and coagulation health. Our experienced hematology team is ready to provide comprehensive evaluation and personalized care. Contact us today to schedule your Von Willebrand Factor Ristocetin Cofactor Activity test.
Call or WhatsApp: +1(267) 388-9828
Our dedicated patient care coordinators are available to answer your questions, assist with appointment scheduling, and provide guidance on test preparation. Don’t let uncertainty about bleeding symptoms affect your quality of life – get the accurate diagnostic information you need with GGC DNA’s advanced coagulation testing services.
