Protein S Antigen Total Test: Comprehensive Coagulation Assessment
Understanding Protein S Antigen Total Testing
The Protein S Antigen Total Test represents a sophisticated diagnostic evaluation that plays a critical role in assessing your body’s natural anticoagulation system. Protein S is a vitamin K-dependent plasma protein that functions as a cofactor for activated Protein C, working synergistically to regulate blood coagulation and prevent excessive clot formation. This essential protein exists in both free and bound forms within the bloodstream, with the total antigen measurement providing comprehensive insight into your overall Protein S status.
What Does the Protein S Antigen Total Test Measure?
This advanced laboratory assessment specifically quantifies the total concentration of Protein S antigen in your blood plasma, including both the free active form and the bound inactive form complexed with C4b-binding protein. The test employs immunoturbidimetric methodology, a highly precise analytical technique that measures light scattering caused by antigen-antibody complex formation, ensuring exceptional accuracy and reliability in results.
- Total Protein S antigen concentration measurement
- Assessment of both free and bound Protein S forms
- Evaluation of natural anticoagulant system function
- Identification of quantitative Protein S deficiencies
Who Should Consider Protein S Antigen Total Testing?
This specialized coagulation test is particularly important for individuals experiencing symptoms or having risk factors associated with thrombophilia and coagulation disorders. Consider scheduling this essential assessment if you present with any of the following indications:
Clinical Indications and Symptoms
- Unexplained deep vein thrombosis (DVT) or pulmonary embolism
- Recurrent spontaneous miscarriages, especially in the second trimester
- Family history of thrombophilia or coagulation disorders
- Unexplained arterial thrombosis at a young age
- History of unusual clotting episodes without apparent cause
- Patients with liver disease or vitamin K deficiency
- Individuals taking anticoagulant medications requiring baseline assessment
Comprehensive Benefits of Protein S Antigen Total Testing
Undergoing Protein S Antigen Total testing provides numerous clinical advantages for both diagnosis and long-term health management:
Diagnostic and Therapeutic Benefits
- Early Detection: Identifies Protein S deficiencies before serious clotting events occur
- Risk Assessment: Evaluates individual thrombophilia risk for personalized prevention strategies
- Treatment Guidance: Informs appropriate anticoagulation therapy decisions
- Family Screening: Helps identify hereditary coagulation disorders in family members
- Pregnancy Management: Assists in managing thrombophilia risks during pregnancy
- Monitoring Capability: Provides baseline for tracking treatment effectiveness
Understanding Your Test Results
Interpreting Protein S Antigen Total test results requires careful consideration of various clinical factors. Our hematology specialists provide comprehensive guidance to help you understand your specific findings:
Result Interpretation Guidelines
- Normal Range: Typically 60-130% of normal plasma activity indicates adequate Protein S levels
- Mild Deficiency: 40-59% may suggest increased thrombosis risk requiring monitoring
- Moderate Deficiency: 20-39% often indicates significant thrombophilia risk
- Severe Deficiency: Below 20% represents high thrombosis risk requiring intervention
- Elevated Levels: Usually not clinically significant but may warrant further investigation
It’s important to note that Protein S levels can be affected by various factors including age, pregnancy, oral contraceptive use, liver function, and vitamin K status. Our specialists consider these variables when interpreting your results and developing personalized management plans.
Test Pricing and Availability
We are committed to making essential diagnostic testing accessible and affordable. Our competitive pricing structure ensures you receive premier laboratory services without financial burden:
| Test Name | Regular Price | Discount Price |
|---|---|---|
| Protein S Antigen Total Test | $700 USD | $500 USD |
Nationwide Accessibility
GGC DNA maintains comprehensive testing facilities across the United States, ensuring convenient access to premier diagnostic services. Our network includes specialized collection centers in:
- New York City and surrounding metropolitan areas
- Los Angeles and Southern California regions
- Chicago and Illinois healthcare facilities
- Houston and Texas medical centers
- Phoenix and Arizona diagnostic locations
- Philadelphia and Pennsylvania testing sites
- San Antonio and additional major urban centers
Sample Collection and Processing Information
Proper sample collection is essential for accurate Protein S Antigen Total testing results. Our standardized protocol ensures optimal sample integrity:
Collection Requirements
- Sample Type: 3 mL whole blood collected in 1 Blue Top (Sodium Citrate) tube
- Preparation: Mix thoroughly by inversion immediately after collection
- Transport: Deliver to laboratory within 4 hours of collection
- Alternative Processing: If immediate transport isn’t possible, prepare platelet-poor plasma within 1 hour through dual centrifugation
- Storage: Freeze immediately and ship frozen; do not thaw
- Fasting: Overnight fasting is preferred for optimal results
Required Documentation
Complete the Coagulation Requisition Form (Form 15) and Test Send Out Consent Form (Form 35) prior to sample collection. Our staff will assist with proper form completion to ensure regulatory compliance and accurate test processing.
Take Control of Your Coagulation Health Today
Don’t leave your coagulation health to chance. The Protein S Antigen Total Test provides essential insights into your body’s natural anticoagulation system, helping identify potential risks before they become serious health concerns. Our specialized hematology team is ready to provide comprehensive testing, accurate interpretation, and personalized guidance.
Schedule your Protein S Antigen Total Test today by calling our dedicated healthcare line at +1(267) 388-9828 or book your appointment online through our secure patient portal. Take the first step toward understanding your coagulation profile and ensuring optimal hematological health with GGC DNA’s premier diagnostic services.
