WNT10B Gene Split-Hand/Foot Malformation Type 6 NGS Genetic DNA Test

Comprehensive Genetic Analysis for Limb Development Disorders

The WNT10B Gene Split-Hand/Foot Malformation Type 6 NGS Genetic DNA Test represents a significant advancement in genetic diagnostics for congenital limb abnormalities. This specialized test focuses on identifying mutations in the WNT10B gene, which plays a crucial role in embryonic development and limb formation. Split-hand/foot malformation type 6 is a rare genetic condition characterized by missing fingers, toes, and central defects in hands and feet, making accurate genetic diagnosis essential for proper management and family planning.

What This Test Measures and Detects

Our advanced NGS (Next-Generation Sequencing) technology provides comprehensive analysis of the WNT10B gene to identify:

• Pathogenic variants and mutations in the WNT10B gene
• Single nucleotide polymorphisms (SNPs) associated with split-hand/foot malformation
• Copy number variations affecting gene function
• Inheritance patterns for genetic counseling purposes
• Specific genetic markers linked to limb development abnormalities

Who Should Consider This Genetic Test

This test is recommended for individuals presenting with:

• Congenital hand or foot deformities including missing digits
• Family history of split-hand/foot malformation or similar limb abnormalities
• Unexplained skeletal development disorders in children
• Couples planning pregnancy with known family history of genetic limb conditions
• Individuals with syndromic features involving limb malformations
• Patients requiring definitive diagnosis for treatment planning

Key Symptoms and Clinical Indications

Common symptoms that may indicate the need for WNT10B genetic testing include:

• Split-hand deformity with missing central fingers
• Split-foot malformation with absent central toes
• Syndactyly (fused digits) in hands or feet
• Reduced number of fingers or toes
• Abnormal hand or foot shape from birth
• Associated skeletal abnormalities in limbs

Benefits of WNT10B Genetic Testing

Accurate Diagnosis and Treatment Planning

Genetic confirmation of WNT10B mutations provides:

• Definitive diagnosis for proper medical management
• Guidance for surgical interventions and rehabilitation
• Understanding of disease progression and prognosis
• Basis for personalized treatment approaches

Family Planning and Genetic Counseling

Our testing supports informed reproductive decisions through:

• Identification of inheritance patterns (autosomal dominant)
• Risk assessment for future pregnancies
• Preimplantation genetic diagnosis options
• Comprehensive genetic counseling services

Advanced Technology and Reliability

Utilizing state-of-the-art NGS technology ensures:

• High accuracy and sensitivity in mutation detection
• Comprehensive coverage of the WNT10B gene
• Reliable results for clinical decision-making
• Adherence to international quality standards

Understanding Your Test Results

Positive Result Interpretation

A positive result indicates the presence of a pathogenic mutation in the WNT10B gene:

• Confirms diagnosis of split-hand/foot malformation type 6
• Provides information about specific genetic variant
• Helps determine inheritance risk for family members
• Guides appropriate medical management strategies

Negative Result Interpretation

A negative result suggests no detectable mutations in the WNT10B gene:

• May rule out WNT10B-related split-hand/foot malformation
• Could indicate other genetic causes for limb abnormalities
• May require additional genetic testing for comprehensive evaluation
• Should be interpreted in clinical context with physician guidance

Variant of Uncertain Significance (VUS)

Some results may identify genetic changes with unknown clinical significance:

• Requires careful interpretation by genetic specialists
• May need family studies for clarification
• Ongoing research may provide future insights
• Regular follow-up recommended as knowledge evolves

Test Information and Pricing

Pre-Test Requirements and Preparation

Essential Documentation

Before testing, please provide:

• Complete clinical history of the patient
• Detailed family medical history
• Photographs of limb abnormalities (if available)
• Previous genetic test results (if any)

Genetic Counseling Session

We recommend a pre-test genetic counseling session to:

• Create a detailed pedigree chart of affected family members
• Discuss testing implications and potential outcomes
• Address questions and concerns about the testing process
• Provide information about result interpretation and next steps

Nationwide Testing Availability

We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including:

• New York City and surrounding areas
• Los Angeles and Southern California region
• Chicago and Midwest locations
• Houston and Texas facilities
• Phoenix and Arizona centers
• Philadelphia and Pennsylvania locations
• And many other cities nationwide

Take the Next Step Toward Genetic Clarity

Don’t let uncertainty about genetic conditions affect your family’s future. Our WNT10B genetic testing provides the answers you need for informed medical decisions and family planning. With our specialized expertise in genetic diagnostics and commitment to patient care, we’re here to support you through every step of the testing process.

Ready to schedule your test? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online. Our team is available to answer your questions and guide you through the testing process with compassion and expertise.

Take control of your genetic health with comprehensive WNT10B testing from America’s trusted genetic diagnostics provider. Schedule your test today and get the clarity you deserve for only $500 USD.