Purkinje Cell Cytoplasmic Antibody Type Tr DNER Test
Comprehensive Neurological Autoimmune Testing
The Purkinje Cell Cytoplasmic Antibody Type Tr DNER Test represents a cutting-edge advancement in neurological diagnostics, specifically designed to detect autoimmune responses targeting the cerebellum’s Purkinje cells. This specialized test identifies antibodies against the Delta/Notch-like EGF repeat-containing protein (DNER), a critical biomarker for autoimmune cerebellar disorders that can significantly impact coordination, balance, and motor function.
What Does This Test Measure?
This sophisticated diagnostic test specifically detects and measures autoantibodies directed against the DNER protein, which is predominantly expressed in Purkinje cells of the cerebellum. These specialized neurons play a crucial role in coordinating voluntary movements, maintaining balance, and ensuring smooth motor control. When the immune system mistakenly targets DNER, it can lead to progressive neurological symptoms that significantly impact quality of life.
Key Detection Capabilities:
- Anti-DNER autoantibodies in serum or cerebrospinal fluid
- Autoimmune responses targeting cerebellar Purkinje cells
- Specific biomarkers for paraneoplastic cerebellar degeneration
- Immune-mediated cerebellar ataxia indicators
Who Should Consider This Test?
This specialized neurological test is recommended for individuals experiencing unexplained neurological symptoms that may indicate autoimmune cerebellar involvement. Early detection through this test can lead to timely intervention and improved treatment outcomes.
Common Symptoms and Indications:
- Progressive difficulty with coordination and balance
- Unsteady gait or frequent stumbling
- Slurred speech or dysarthria
- Involuntary eye movements (nystagmus)
- Tremors affecting fine motor skills
- Unexplained dizziness or vertigo
- Patients with suspected paraneoplastic neurological syndromes
- Individuals with autoimmune conditions showing cerebellar symptoms
Benefits of Purkinje Cell Cytoplasmic Antibody Testing
Choosing this advanced diagnostic test provides numerous advantages for patients and healthcare providers seeking accurate neurological diagnosis and targeted treatment planning.
Key Benefits Include:
- Early Diagnosis: Enables prompt identification of autoimmune cerebellar disorders before significant neurological damage occurs
- Treatment Guidance: Results help neurologists develop targeted immunotherapy strategies
- Differential Diagnosis: Distinguishes autoimmune cerebellar ataxia from other neurological conditions
- Prognostic Value: Provides insights into disease progression and potential treatment response
- Comprehensive Assessment: Utilizes both serum and CSF samples for thorough evaluation
Understanding Your Test Results
Interpreting your Purkinje Cell Cytoplasmic Antibody Type Tr DNER Test results requires careful consideration by a qualified neurologist. Here’s a general guide to understanding what your results might indicate:
Possible Result Interpretations:
- Positive Result: Indicates the presence of anti-DNER antibodies, suggesting autoimmune cerebellar involvement that may require immunomodulatory treatment
- Negative Result: Suggests that autoimmune cerebellar ataxia related to DNER antibodies is unlikely, though other causes should still be investigated
- Borderline Results: May require repeat testing or additional neurological evaluation to confirm diagnosis
Your neurologist will correlate these findings with your clinical symptoms, medical history, and other diagnostic tests to develop a comprehensive treatment plan tailored to your specific needs.
Test Pricing and Sample Requirements
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Purkinje Cell Cytoplasmic Antibody Type Tr DNER Test | $526 USD | $700 USD |
Sample Collection Requirements:
- Sample Type: 3 mL (2 mL minimum) serum from 1 Red Top tube OR 2 mL (1 mL minimum) CSF in sterile container
- Important Note: Do not use SST gel barrier tubes
- Shipping: Refrigerated or frozen overnight delivery
- Fasting: Overnight fasting is preferred
- Documentation: Duly filled Test Send Out Consent Form (Form 35) is mandatory
Turnaround Time:
Results are typically available within 2-3 weeks after sample receipt by the 7th of the month. Our advanced CBA-IFA methodology ensures the highest accuracy and reliability in detecting these specialized neurological antibodies.
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas. Our state-of-the-art facilities in New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose ensure accessible neurological testing for patients nationwide.
Take Control of Your Neurological Health Today
Don’t let unexplained neurological symptoms compromise your quality of life. The Purkinje Cell Cytoplasmic Antibody Type Tr DNER Test provides the clarity needed for accurate diagnosis and effective treatment planning. Our experienced neurological specialists are ready to guide you through the testing process and help interpret your results.
Call us today at +1(267) 388-9828 to schedule your test or speak with our neurological testing specialists. Take the first step toward understanding your neurological health and exploring targeted treatment options.
With our comprehensive network of testing centers and commitment to neurological excellence, we make advanced autoimmune cerebellar testing accessible and convenient for patients throughout the United States.
