PML/RARA Qualitative BCR 1 & 3 Test
Understanding the PML/RARA Genetic Test
The PML/RARA Qualitative BCR 1 & 3 test represents a breakthrough in molecular diagnostics for acute promyelocytic leukemia (APL). This sophisticated genetic analysis detects specific chromosomal translocations that are hallmark features of APL, providing clinicians with critical information for accurate diagnosis and targeted treatment strategies.
What Does This Test Measure?
This advanced genetic test specifically identifies the presence of PML-RARA fusion genes resulting from chromosomal translocations between chromosomes 15 and 17. The test focuses on detecting two major breakpoint cluster regions (BCR 1 and BCR 3) that account for the majority of APL cases. Using Real-Time PCR technology, the test provides:
- Detection of PML-RARA gene fusion
- Identification of specific breakpoint regions (BCR 1 & 3)
- Qualitative assessment of genetic abnormalities
- High sensitivity for minimal residual disease monitoring
Who Should Consider This Test?
This specialized genetic test is recommended for individuals presenting with symptoms or clinical findings suggestive of acute promyelocytic leukemia, including:
- Patients with unexplained bleeding or bruising tendencies
- Individuals experiencing persistent fatigue and weakness
- Those with abnormal blood cell counts on routine testing
- Patients with suspected acute myeloid leukemia subtypes
- Individuals requiring treatment response monitoring
- Patients undergoing remission assessment
Clinical Indications and Symptoms
The PML/RARA test is particularly important for patients showing:
- Unexplained coagulopathy or bleeding disorders
- Petechiae or ecchymosis without trauma
- Recurrent infections due to neutropenia
- Bone pain or tenderness
- Enlarged lymph nodes or spleen
- Unexplained weight loss and fever
Benefits of PML/RARA Testing
Choosing the PML/RARA Qualitative BCR 1 & 3 test offers numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Provides definitive identification of APL-specific genetic markers
- Treatment Guidance: Enables targeted therapy with all-trans retinoic acid (ATRA)
- Prognostic Information: Helps assess disease severity and treatment response
- Minimal Residual Disease Monitoring: Detects low levels of disease during treatment
- Rapid Results: 2-3 day turnaround time for timely clinical decisions
- Non-invasive Options: Can be performed on peripheral blood when bone marrow is not available
Test Specifications
| Test Parameter | Details |
|---|---|
| Test Name | PML/RARA Qualitative BCR 1 & 3 |
| Methodology | Real-Time PCR |
| Sample Type | Bone Marrow / Peripheral Blood |
| Transport Requirements | Immediate Transport |
| Collection Tube | EDTA Vacutainer (4ml) |
| Turnaround Time | 2-3 Days |
| Discount Price | $132 USD |
| Regular Price | $176 USD |
Understanding Your Test Results
Interpreting PML/RARA test results requires professional medical expertise, but here’s general guidance:
Positive Results
A positive result indicates the presence of PML-RARA fusion gene, confirming acute promyelocytic leukemia. This finding:
- Confirms APL diagnosis
- Guides specific targeted therapy
- Provides baseline for treatment monitoring
- Helps predict treatment response
Negative Results
A negative result suggests the absence of detectable PML-RARA fusion, which may indicate:
- Absence of APL
- Different leukemia subtype
- Rare breakpoint variants not detected by this assay
- Need for additional diagnostic testing
Pre-Test Instructions
The PML/RARA Qualitative BCR 1 & 3 test requires a doctor’s prescription. Please note that prescriptions are not applicable for:
- Surgery preparation cases
- Pregnancy-related testing
- Individuals planning international travel
Convenient Testing Locations Across USA
We have established testing facilities in all major cities throughout the United States, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our nationwide network ensures accessible genetic testing services with consistent quality standards.
Book Your Test Today
Take the first step toward accurate diagnosis and personalized treatment. Our genetic specialists are ready to assist you with comprehensive testing services and professional guidance.
Call or WhatsApp: +1(267) 388-9828
Schedule your PML/RARA Qualitative BCR 1 & 3 test today and benefit from our discounted price of $132 USD. Our team will guide you through the testing process and ensure you receive your results within 2-3 days.
