PIK3CA Mutation Analysis: Advanced Genetic Testing for Precision Cancer Care
Understanding PIK3CA Mutation Analysis
The PIK3CA Mutation Analysis represents a cutting-edge approach in molecular diagnostics that examines specific genetic alterations in the PIK3CA gene. This gene encodes the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), a critical enzyme involved in cellular signaling pathways that regulate cell growth, proliferation, and survival. When mutations occur in the PIK3CA gene, they can lead to uncontrolled activation of the PI3K pathway, contributing to cancer development and progression.
What Does the Test Measure?
This comprehensive genetic analysis specifically detects:
- Hotspot mutations in the PIK3CA gene exons 9 and 20
- Common activating mutations including E542K, E545K, and H1047R
- Other clinically relevant PIK3CA alterations
- Mutation frequency and variant allele fraction
Who Should Consider PIK3CA Mutation Testing?
This test is particularly valuable for patients with:
- Breast cancer, especially hormone receptor-positive, HER2-negative subtypes
- Advanced or metastatic solid tumors
- Patients being considered for PI3K inhibitor therapy
- Those who have failed conventional treatments
- Individuals seeking personalized treatment options
- Patients with family history of cancer syndromes
Clinical Indications and Symptoms
Healthcare providers typically recommend PIK3CA mutation analysis for patients presenting with:
- Recurrent or treatment-resistant cancers
- Metastatic disease requiring targeted therapy options
- Need for biomarker-guided treatment selection
- Progressive disease despite standard therapies
Benefits of PIK3CA Mutation Analysis
Undergoing this genetic test provides numerous advantages:
- Personalized Treatment Planning: Identifies patients who may benefit from specific PI3K inhibitors
- Improved Outcomes: Helps select therapies with higher likelihood of success
- Reduced Side Effects: Avoids ineffective treatments and their associated toxicities
- Prognostic Information: Provides insights into disease behavior and potential outcomes
- Clinical Trial Eligibility: May qualify patients for targeted therapy trials
- Comprehensive Cancer Management: Enhances overall treatment strategy
Understanding Your Test Results
Your PIK3CA Mutation Analysis results will fall into one of these categories:
- Positive for Mutation: Indicates the presence of PIK3CA mutations, potentially making you eligible for targeted PI3K inhibitor therapies
- Negative for Mutation: No detectable PIK3CA mutations were found, suggesting alternative treatment approaches may be more appropriate
- Variant of Uncertain Significance: A genetic change was detected, but its clinical significance is not yet fully understood
It’s essential to discuss your results with your healthcare provider, who can interpret them in the context of your specific medical situation and treatment goals.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | PIK3CA Mutation Analysis |
| Regular Price | $326 USD |
| Discount Price | $226 USD |
| Turnaround Time | 3 weeks |
| Sample Type | Blood |
| Testing Method | PCR (Polymerase Chain Reaction) |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible testing for patients nationwide.
Take Control of Your Cancer Treatment Journey
Don’t leave your treatment decisions to chance. The PIK3CA Mutation Analysis provides critical information that can guide your healthcare team toward more effective, personalized cancer care. With results available in just 3 weeks and our special discounted price of $226 USD, there’s never been a better time to take this important step in your cancer journey.
Ready to schedule your PIK3CA Mutation Analysis? Call our dedicated patient care team today at +1(267) 388-9828 or book your appointment online. Our genetic counselors and healthcare professionals are available to answer your questions and help you understand how this test can benefit your specific situation.
Take the first step toward precision cancer medicine – contact us now to schedule your comprehensive genetic analysis and unlock personalized treatment options tailored to your unique genetic profile.
