PIK3CA Mutation Analysis Test
Understanding PIK3CA Mutation Analysis
The PIK3CA Mutation Analysis Test represents a breakthrough in precision oncology, offering detailed genetic insights that can transform cancer treatment strategies. This advanced molecular diagnostic test specifically examines the PIK3CA gene, which encodes the p110α catalytic subunit of PI3K (phosphoinositide 3-kinase). When mutations occur in this critical gene, they can lead to uncontrolled cell growth and cancer development by activating the PI3K/AKT/mTOR signaling pathway. Understanding these mutations is essential for modern cancer care, as they directly influence treatment response and patient outcomes.
What Does the PIK3CA Mutation Analysis Test Detect?
This sophisticated genetic test identifies specific mutations within the PIK3CA gene that are known to drive cancer progression. The analysis focuses on:
- Hotspot mutations in exons 9 and 20 of the PIK3CA gene
- Common activating mutations including E542K, E545K, and H1047R
- Other less frequent but clinically relevant PIK3CA alterations
- Genetic variations that confer sensitivity to PI3K inhibitors
Who Should Consider PIK3CA Mutation Testing?
This test is particularly valuable for patients with specific cancer types and clinical presentations:
- Patients diagnosed with hormone receptor-positive, HER2-negative breast cancer
- Individuals with colorectal cancer, especially those with metastatic disease
- Patients with head and neck squamous cell carcinoma
- Those with endometrial cancer and other gynecological malignancies
- Patients who have failed conventional therapies and need alternative treatment options
- Individuals seeking personalized treatment approaches based on their tumor’s genetic profile
Clinical Indications and Symptoms
Consider PIK3CA mutation analysis if you or your patient presents with:
- Advanced or metastatic cancer requiring targeted therapy options
- Recurrent disease following standard treatment protocols
- Cancer types known to frequently harbor PIK3CA mutations
- Need for biomarker-guided treatment selection
- Desire for comprehensive molecular profiling of tumor tissue
Benefits of PIK3CA Mutation Analysis
Undergoing PIK3CA mutation testing provides numerous advantages for cancer patients and their healthcare teams:
- Personalized Treatment Selection: Identifies patients who may benefit from specific PI3K inhibitor medications
- Improved Treatment Outcomes: Helps select therapies with higher likelihood of success based on genetic markers
- Reduced Treatment Toxicity: Avoids ineffective treatments and their associated side effects
- Informed Clinical Decisions: Provides evidence-based guidance for therapy selection
- Comprehensive Cancer Profiling: Contributes to a complete molecular picture of the tumor
- Clinical Trial Eligibility: May qualify patients for targeted therapy clinical trials
Understanding Your Test Results
Interpreting PIK3CA mutation analysis results requires careful consideration by your healthcare provider:
Positive Result (Mutation Detected)
A positive result indicates the presence of one or more PIK3CA mutations in the tumor tissue. This finding may:
- Suggest potential responsiveness to PI3K inhibitor therapies
- Provide rationale for targeted treatment approaches
- Inform prognosis and treatment planning
- Guide discussions about clinical trial opportunities
Negative Result (No Mutation Detected)
A negative result means no clinically significant PIK3CA mutations were identified. This outcome:
- May indicate alternative treatment approaches are needed
- Does not rule out other targetable genetic alterations
- Should be considered alongside other biomarker testing results
- May still provide valuable information for treatment exclusion
Technical Considerations
It’s important to understand that test results depend on several factors:
- Tumor tissue quality and cellularity (minimum 10% tumor content required)
- Specific mutation detection sensitivity of the testing methodology
- Sample preparation and handling procedures
- Regional heterogeneity within the tumor
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | PIK3CA Mutation Analysis Test |
| Regular Price | $300 USD |
| Discount Price | $188 USD |
| Turnaround Time | Sample Tuesday by 11 AM; Report Monday |
| Sample Type | Formalin fixed paraffin embedded tissue block |
| Testing Method | PCR and Sequencing |
Sample Requirements and Instructions
For accurate testing, please ensure:
- Submit formalin fixed paraffin embedded tissue block
- Ship at room temperature with proper packaging
- Block must contain at least 10% tumor tissue
- Complete NGS Test Requisition Form (Form 40) is mandatory
- Include relevant clinical information and patient history
Nationwide Testing Availability
GGC DNA provides comprehensive PIK3CA Mutation Analysis testing across the United States, with convenient locations in major cities including:
- New York City and surrounding metropolitan areas
- Los Angeles and Southern California regions
- Chicago and Illinois healthcare facilities
- Houston, Dallas, and Texas medical centers
- Philadelphia and Pennsylvania diagnostic centers
- Phoenix, Arizona and surrounding communities
- San Antonio, Texas area medical providers
- San Diego, California healthcare networks
- Jacksonville, Florida medical facilities
- Columbus, Ohio and Midwest regions
Take Control of Your Cancer Treatment Journey
Don’t leave your treatment decisions to chance. The PIK3CA Mutation Analysis Test provides the genetic insights needed to make informed decisions about your cancer care. With our special discounted price of only $188 USD (regularly $300), this advanced testing is more accessible than ever.
Ready to get started? Book your PIK3CA Mutation Analysis Test today!
Call our dedicated healthcare team at +1(267) 388-9828 to schedule your test or discuss testing options with one of our genetic specialists. We’re here to help you navigate your cancer treatment journey with confidence and clarity.
Take the first step toward personalized cancer care. Contact GGC DNA now and discover how genetic testing can transform your treatment approach.
