PDGFRB Gene Myeloproliferative Disorder Chronic with Eosinophilia NGS Genetic DNA Test
Comprehensive Genetic Analysis for Rare Blood Disorders
The PDGFRB Gene Myeloproliferative Disorder Chronic with Eosinophilia NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for rare hematological conditions. This advanced genetic screening specifically targets mutations in the Platelet-Derived Growth Factor Receptor Beta (PDGFRB) gene, which plays a critical role in regulating blood cell development and proliferation. When mutations occur in this gene, they can trigger abnormal growth of eosinophils and other blood cells, leading to chronic myeloproliferative disorders that require precise diagnosis and targeted treatment approaches.
What This Revolutionary Test Detects
Our sophisticated NGS-based genetic analysis identifies specific mutations within the PDGFRB gene that are known to cause myeloproliferative disorders with eosinophilia. The test comprehensively examines:
- Point mutations and small insertions/deletions in the PDGFRB gene
- Fusion genes involving PDGFRB with partner genes
- Activating mutations that lead to constitutive tyrosine kinase activity
- Genetic variants associated with treatment response to tyrosine kinase inhibitors
- Novel mutations that may contribute to disease pathogenesis
Who Should Consider This Genetic Testing?
This specialized genetic test is recommended for individuals presenting with specific clinical manifestations that suggest PDGFRB-related disorders:
Clinical Indications and Symptoms
- Unexplained persistent eosinophilia (eosinophil count >1.5 × 10⁹/L)
- Chronic myeloproliferative features without clear diagnosis
- Splenomegaly or hepatomegaly of unknown origin
- Constitutional symptoms including fatigue, weight loss, and night sweats
- Skin manifestations such as urticaria, angioedema, or dermatitis
- Cardiac involvement including endomyocardial fibrosis
- Neurological symptoms related to eosinophilic tissue infiltration
- Family history of similar hematological disorders
Significant Benefits of Genetic Testing
Undergoing PDGFRB genetic testing provides numerous advantages for both patients and healthcare providers:
Diagnostic Precision and Treatment Guidance
- Definitive Diagnosis: Provides conclusive genetic evidence for PDGFRB-related disorders
- Targeted Therapy Selection: Guides appropriate use of tyrosine kinase inhibitors like imatinib
- Prognostic Information: Helps predict disease course and potential complications
- Family Screening: Enables genetic counseling and testing for at-risk relatives
- Treatment Monitoring: Allows for molecular monitoring of treatment response
- Avoidance of Unnecessary Treatments: Prevents inappropriate use of corticosteroids or chemotherapy
Understanding Your Test Results
Our comprehensive genetic report provides clear interpretation of your PDGFRB gene analysis:
Result Interpretation Guidelines
- Positive Result: Indicates the presence of a pathogenic PDGFRB mutation, confirming the diagnosis and guiding targeted therapy options
- Negative Result: Suggests that PDGFRB mutations are not detected, though other genetic causes should be considered
- Variant of Uncertain Significance: Identifies genetic changes with unclear clinical implications, requiring further evaluation
- Carrier Status: Provides information about inheritance patterns and family planning considerations
Test Specifications and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | PDGFRB Gene Myeloproliferative Disorder Chronic with Eosinophilia NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
| Specialty | Hematology Genetics |
Pre-Test Requirements and Genetic Counseling
To ensure optimal testing outcomes, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session to discuss testing implications
- Development of detailed family pedigree chart
- Review of potential benefits and limitations of testing
- Discussion of insurance coverage and financial considerations
Nationwide Accessibility and Convenience
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures easy access to this advanced genetic testing regardless of your location.
Take Control of Your Health Today
Don’t let uncertainty about your hematological condition delay proper diagnosis and treatment. Our PDGFRB genetic testing provides the clarity needed for effective medical management. With our discounted price of only $500 USD, advanced genetic insights are more accessible than ever.
Ready to schedule your test? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online. Our team is available to answer your questions and guide you through the testing process with compassion and expertise.
