Oncomine Juvenile Myelomonocytic Leukemia JMML Panel Test
Comprehensive Genetic Testing for Juvenile Myelomonocytic Leukemia
The Oncomine Juvenile Myelomonocytic Leukemia (JMML) Panel Test represents a cutting-edge diagnostic advancement in pediatric hematology and oncology. JMML is a rare and aggressive form of childhood leukemia that primarily affects children under four years of age, characterized by the excessive production of myelomonocytic cells. This comprehensive genetic panel utilizes next-generation sequencing (NGS) technology to provide precise molecular characterization of JMML, enabling accurate diagnosis and personalized treatment planning.
What Does the JMML Panel Test Measure?
Our advanced NGS panel specifically targets 13 critical genes known to be involved in JMML pathogenesis:
- ASXL1 – Associated with epigenetic regulation and disease progression
- CBL – Critical for RAS pathway signaling and ubiquitination
- DNMT3A – Involved in DNA methylation patterns
- EZH2 – Polycomb group protein with histone methyltransferase activity
- GATA2 – Transcription factor essential for hematopoiesis
- KRAS – Key component of RAS/MAPK signaling pathway
- NF1 – Neurofibromin 1, a tumor suppressor gene
- NRAS – Another crucial RAS family member
- PTPN11 – Protein tyrosine phosphatase non-receptor type 11
- RUNX1 – Runt-related transcription factor 1
- SETBP1 – SET binding protein 1
- SH2B3 – Adaptor protein in cytokine signaling
- ZRSR2 – Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Who Should Consider This Test?
This specialized genetic panel is recommended for children presenting with symptoms suggestive of JMML, including:
- Unexplained fever, fatigue, and pallor
- Recurrent infections and bleeding tendencies
- Hepatosplenomegaly (enlarged liver and spleen)
- Lymphadenopathy (swollen lymph nodes)
- Skin rashes or eczematous lesions
- Abnormal blood counts with monocytosis
- Children with neurofibromatosis type 1 (NF1)
- Noonan syndrome patients with suspicious hematological findings
Key Benefits of the Oncomine JMML Panel Test
- Accurate Diagnosis: Differentiates JMML from other childhood leukemias and myeloproliferative disorders
- Prognostic Information: Specific mutations provide insights into disease severity and progression
- Treatment Guidance: Identifies potential targets for targeted therapies
- Family Planning: Helps identify inherited genetic predispositions
- Monitoring Tool: Enables tracking of minimal residual disease after treatment
- Comprehensive Analysis: Single test covering multiple genetic pathways involved in JMML
Understanding Your Test Results
Your comprehensive test report will include detailed information about detected mutations, their clinical significance, and implications for treatment. Results are typically categorized as:
- Pathogenic Variants: Mutations known to cause JMML with established clinical significance
- Likely Pathogenic Variants: Mutations strongly suspected to be disease-causing
- Variants of Uncertain Significance: Genetic changes with unknown clinical impact
- Likely Benign/Benign Variants: Genetic variations not associated with disease
Our genetic counselors and hematology specialists will help interpret your results and discuss appropriate next steps for management and treatment.
Test Pricing Information
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $1024 |
| Regular Price | $1138 |
Sample Requirements and Turnaround Time
Sample Type: 3 mL (2 mL minimum) whole blood OR bone marrow in 1 lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE.
Mandatory Requirement: Duly filled NGS Test Requisition Form (Form 40) must accompany all samples.
Turnaround Time: Samples received by the 1st or 16th of each month will have reports available by the 15th or 30th of the same month, respectively.
Nationwide Accessibility
We have diagnostic branches conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures that patients and healthcare providers nationwide have access to this critical diagnostic testing.
Book Your Test Today
Take the first step toward precise diagnosis and personalized treatment for Juvenile Myelomonocytic Leukemia. Our team of genetic specialists, hematologists, and oncologists are ready to assist you with comprehensive testing and expert interpretation.
Call or WhatsApp: +1(267) 388-9828 to schedule your Oncomine JMML Panel Test or to speak with our genetic counseling team.
Early and accurate diagnosis is crucial for effective JMML management. Contact us today to learn more about how this advanced genetic testing can benefit your patient or loved one.
