NRAS Mutation Codon 12, 13, 61 Test
Comprehensive Genetic Analysis for Cancer Treatment Planning
The NRAS Mutation Codon 12, 13, 61 Test represents a cutting-edge molecular diagnostic approach that examines specific genetic alterations in the NRAS gene, providing critical information for cancer management and treatment decisions. This sophisticated genetic analysis focuses on three key mutation hotspots—codons 12, 13, and 61—that are frequently implicated in various cancer types and significantly impact treatment response and disease progression.
What Does the NRAS Mutation Test Measure?
This advanced genetic test specifically detects mutations occurring at three critical locations within the NRAS gene:
- Codon 12 Mutations: Genetic alterations at position 12 that affect protein function
- Codon 13 Mutations: Specific changes at position 13 impacting cellular signaling
- Codon 61 Mutations: Transformations at position 61 influencing cancer development
The NRAS gene belongs to the RAS family of oncogenes and plays a pivotal role in regulating cell growth, division, and survival. When mutations occur at these specific codons, they can lead to constitutive activation of the NRAS protein, driving uncontrolled cell proliferation and contributing to cancer development.
Who Should Consider NRAS Mutation Testing?
This specialized genetic test is particularly recommended for individuals with:
- Diagnosed melanoma requiring treatment planning
- Colorectal cancer patients evaluating targeted therapy options
- Patients with thyroid cancer for prognostic assessment
- Individuals with hematological malignancies
- Patients with treatment-resistant cancers
- Those being considered for RAS-targeted therapies
Clinical Benefits of NRAS Mutation Analysis
Undergoing NRAS mutation testing provides numerous clinical advantages:
- Personalized Treatment Selection: Identifies patients who may benefit from specific targeted therapies
- Prognostic Information: Helps predict disease course and treatment response
- Therapeutic Guidance: Informs decisions about RAS pathway inhibitors
- Clinical Trial Eligibility: Determines qualification for novel treatment protocols
- Comprehensive Cancer Profiling: Complements other genetic testing for holistic cancer management
Understanding Your Test Results
Your NRAS mutation test results will fall into one of several categories:
- Mutation Detected: Indicates the presence of NRAS mutations, which may influence treatment decisions and prognosis
- No Mutation Detected: Suggests standard NRAS gene sequence, potentially opening different treatment avenues
- Inconclusive Results: May require additional testing or sample collection
It’s essential to discuss your results with your oncologist or genetic counselor, who can provide personalized interpretation based on your specific cancer type, stage, and overall health status.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $212 |
| Regular Price | $376 |
Nationwide Testing Availability
GGC DNA provides comprehensive NRAS mutation testing services across the United States, with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our advanced molecular diagnostics laboratories ensure accurate, reliable results with rapid turnaround times.
Sample Requirements and Processing
For optimal testing accuracy, please ensure:
- Submit formalin-fixed paraffin-embedded tissue block
- Ship samples at room temperature
- Ensure block contains at least 10% tumor tissue
- Complete NGS Test Requisition Form (Form 40)
- Sample processing: Tuesday by 11 AM
- Report delivery: Monday
Take Control of Your Cancer Treatment Journey
Understanding your genetic profile is crucial for making informed decisions about your cancer treatment. The NRAS Mutation Codon 12, 13, 61 Test provides valuable insights that can significantly impact your treatment strategy and overall outcomes.
Ready to schedule your NRAS mutation test? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online to begin your personalized cancer genetic assessment.
