Neuronal Paraneoplastic Autoantibodies Profile Test
Understanding Paraneoplastic Neurological Syndromes
Paraneoplastic neurological syndromes represent a group of rare disorders that occur when cancer-fighting antibodies mistakenly attack normal cells in the nervous system. These conditions typically develop before a cancer diagnosis is made, making early detection crucial for both neurological management and cancer treatment. The Neuronal Paraneoplastic Autoantibodies Profile Test serves as a vital diagnostic tool in identifying these autoimmune responses.
What This Test Measures
The Neuronal Paraneoplastic Autoantibodies Profile Test utilizes advanced immunoblot technology to detect specific autoantibodies associated with paraneoplastic neurological disorders. The comprehensive profile includes:
- Amphiphysin Antibodies: Associated with stiff-person syndrome and encephalomyelitis
- CV2 Antibodies: Linked to cerebellar degeneration and peripheral neuropathy
- PNMA2 (Ma2/Ta) Antibodies: Often found in limbic encephalitis and brainstem dysfunction
- ANNA-1/Hu Antibodies: Associated with various neurological syndromes including encephalomyelitis
- ANNA-2/Ri Antibodies: Typically seen in opsoclonus-myoclonus syndrome
- PCA-1/Yo Antibodies: Strongly associated with cerebellar degeneration
Who Should Consider This Test
This specialized testing is recommended for individuals experiencing unexplained neurological symptoms, particularly when cancer is suspected but not yet diagnosed. Key indications include:
- Progressive neurological symptoms without clear explanation
- Rapidly developing cognitive impairment or memory loss
- Muscle weakness, stiffness, or coordination problems
- Sensory changes including numbness or tingling
- Visual disturbances or eye movement abnormalities
- Seizures or movement disorders of unknown origin
- Patients with known cancer who develop new neurological symptoms
Clinical Benefits of Early Detection
Early identification of paraneoplastic autoantibodies offers significant clinical advantages:
- Early Cancer Detection: Often identifies underlying malignancies before conventional screening methods
- Targeted Treatment: Enables specific immunotherapy approaches for neurological symptoms
- Improved Prognosis: Early intervention can prevent permanent neurological damage
- Comprehensive Care Planning: Guides both neurological and oncological treatment strategies
- Family Awareness: Helps identify potential hereditary cancer syndromes in some cases
Understanding Your Test Results
Test results should always be interpreted by qualified healthcare professionals in the context of your complete clinical picture:
- Positive Results: Indicate the presence of specific autoantibodies associated with paraneoplastic syndromes. This typically warrants comprehensive cancer screening and neurological evaluation.
- Negative Results: Do not completely rule out paraneoplastic syndromes, as not all associated antibodies may be included in the panel.
- Borderline Results: May require repeat testing or additional specialized testing for confirmation.
- Clinical Correlation: Results must be correlated with symptoms, imaging findings, and other diagnostic information.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $300 |
| Regular Price | $450 |
Convenient Testing Process
GGC DNA makes neurological testing accessible and convenient across the United States:
- Sample Collection: 2 mL serum sample collected Monday through Saturday by 9 AM
- Rapid Results: Same-day reporting when samples are received by cutoff time
- No Special Preparation: No fasting or special preparation required
- Nationwide Coverage: Testing facilities available in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose
- Expert Interpretation: Results reviewed by board-certified neurologists and oncologists
Take Control of Your Neurological Health
Don’t let unexplained neurological symptoms go undiagnosed. The Neuronal Paraneoplastic Autoantibodies Profile Test provides crucial information that can lead to early cancer detection and appropriate neurological care. Our team of specialists is ready to help you understand your symptoms and guide you toward the right diagnostic path.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Early detection saves lives and preserves neurological function.