NCF4 Gene Granulomatous Disease Chronic Autosomal Recessive Cytochrome b-Positive Type 3 NGS Genetic DNA Test
Comprehensive Genetic Testing for Chronic Granulomatous Disease Type 3
The NCF4 Gene Granulomatous Disease Chronic Autosomal Recessive Cytochrome b-Positive Type 3 NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for immune system disorders. This advanced genetic analysis specifically targets mutations in the NCF4 gene, which plays a critical role in the proper functioning of neutrophil phagocytes. When this gene malfunctions, it leads to chronic granulomatous disease type 3, a rare inherited condition where the immune system cannot effectively combat certain bacterial and fungal infections.
What This Test Measures and Detects
Our state-of-the-art NGS (Next-Generation Sequencing) technology provides comprehensive analysis of the NCF4 gene to identify:
- Point mutations and single nucleotide variants in the NCF4 gene sequence
- Small insertions and deletions affecting gene function
- Autosomal recessive inheritance patterns characteristic of CGD type 3
- Specific genetic markers associated with cytochrome b-positive status
- Pathogenic variants that disrupt NADPH oxidase complex formation
The test examines the complete coding region and critical regulatory elements of the NCF4 gene, ensuring comprehensive mutation detection with exceptional accuracy exceeding 99.9%.
Who Should Consider This Genetic Test
This specialized genetic testing is recommended for individuals presenting with:
- Recurrent bacterial and fungal infections despite standard treatments
- Unexplained granuloma formation in various organs
- Family history of chronic granulomatous disease or immune deficiencies
- Abnormal neutrophil function test results
- Persistent lymphadenopathy or hepatosplenomegaly
- Delayed separation of the umbilical cord in infancy
- Chronic inflammatory conditions without clear autoimmune cause
- Suspected primary immunodeficiency disorders
Clinical Benefits of NCF4 Gene Testing
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Accurate Diagnosis: Confirms or rules out chronic granulomatous disease type 3 with molecular precision
- Personalized Treatment: Enables targeted therapeutic approaches based on specific genetic mutations
- Family Planning: Provides crucial information for genetic counseling and reproductive decisions
- Early Intervention: Facilitates proactive management before severe complications develop
- Disease Monitoring: Establishes baseline genetic information for ongoing clinical management
- Research Contribution: Advances scientific understanding of rare immune disorders
Understanding Your Test Results
Our comprehensive genetic report includes detailed interpretation of your NCF4 gene analysis:
- Positive Result: Identifies specific pathogenic mutations in the NCF4 gene, confirming diagnosis of chronic granulomatous disease type 3. This result enables targeted treatment planning and family member testing.
- Negative Result: No disease-causing mutations detected in the NCF4 gene, effectively ruling out this specific form of CGD while suggesting alternative diagnostic considerations.
- Variant of Uncertain Significance: Identifies genetic changes with unclear clinical impact, requiring correlation with clinical symptoms and potentially additional family studies.
- Carrier Status: Detects individuals with single mutated NCF4 gene copies who are typically asymptomatic but can pass the condition to offspring.
Test Pricing and Sample Requirements
| Test Component | Details |
|---|---|
| Test Name | NCF4 Gene Granulomatous Disease Chronic Autosomal Recessive Cytochrome b-Positive Type 3 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
National Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many more. Our nationwide network ensures accessible genetic testing services regardless of your location.
Take Control of Your Genetic Health Today
Don’t let uncertainty about genetic conditions affect your quality of life. Our expert team of genetic counselors and hematology specialists are ready to guide you through the testing process and provide comprehensive support. Early genetic diagnosis can significantly improve treatment outcomes and quality of life for individuals with chronic granulomatous disease.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your NCF4 gene test. Our compassionate team is available to answer your questions and help you take the next step toward genetic clarity and improved health management.
