Myeloproliferative Neoplasia MPN Panel (BCR-ABL, JAK2, CALR, MPL)
Comprehensive Genetic Testing for Blood Disorders
The Myeloproliferative Neoplasia MPN Panel represents a cutting-edge diagnostic approach for identifying genetic mutations associated with rare blood cancers and bone marrow disorders. This comprehensive genetic screening utilizes Next-Generation Sequencing (NGS) technology to detect specific mutations in four critical genes: BCR-ABL, JAK2, CALR, and MPL. These genetic markers are essential for accurate diagnosis and classification of myeloproliferative neoplasms, enabling healthcare providers to develop targeted treatment strategies and improve patient outcomes.
What Does the MPN Panel Detect?
This advanced genetic panel specifically identifies mutations in key genes responsible for regulating blood cell production:
- BCR-ABL Fusion Gene: Associated with chronic myeloid leukemia and certain acute lymphoblastic leukemias
- JAK2 Mutations: Particularly JAK2 V617F, commonly found in polycythemia vera, essential thrombocythemia, and primary myelofibrosis
- CALR Mutations: Calreticulin gene mutations frequently present in essential thrombocythemia and primary myelofibrosis
- MPL Mutations: Thrombopoietin receptor mutations associated with essential thrombocythemia and primary myelofibrosis
Who Should Consider This Test?
The MPN Panel is recommended for individuals experiencing symptoms or laboratory findings suggestive of myeloproliferative disorders:
- Unexplained elevated blood cell counts (red cells, white cells, or platelets)
- Persistent fatigue, weakness, or unexplained weight loss
- Enlarged spleen (splenomegaly) or liver
- Night sweats, itching after bathing (aquagenic pruritus)
- Bone pain or discomfort
- Abnormal bleeding or clotting tendencies
- Family history of blood disorders or hematologic cancers
- Abnormal bone marrow biopsy results
Benefits of MPN Genetic Testing
Undergoing the Myeloproliferative Neoplasia Panel offers numerous advantages for accurate diagnosis and treatment planning:
- Precise Diagnosis: Differentiates between various MPN subtypes for accurate classification
- Targeted Treatment: Identifies mutations that may respond to specific targeted therapies
- Prognostic Information: Provides insights into disease progression and potential complications
- Treatment Monitoring: Enables tracking of treatment response and disease evolution
- Family Risk Assessment: Helps identify potential hereditary components in certain cases
- Personalized Care: Facilitates development of individualized treatment strategies
Understanding Your Test Results
Your MPN Panel results will provide detailed information about the presence or absence of specific genetic mutations:
- Positive for Mutation: Indicates the presence of a specific genetic alteration associated with MPN
- Negative for Mutation: Suggests absence of the tested mutations, though other genetic changes may be present
- Variant of Unknown Significance: Some genetic changes may require additional clinical correlation
- Quantitative Results: For certain mutations, the test may provide information about mutation burden
It’s essential to discuss your results with a qualified hematologist or oncologist who can interpret the findings in the context of your complete clinical picture and recommend appropriate management strategies.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | Myeloproliferative Neoplasia MPN Panel (BCR-ABL, JAK2, CALR, MPL) |
| Discount Price | $550 USD |
| Regular Price | $700 USD |
| Turnaround Time | 15 working days |
| Sample Type | Blood |
| Test Components | EDTA Vacutainer (2ml) |
| Testing Method | Next-Generation Sequencing (NGS) |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee. Our network ensures accessible testing services for patients throughout the country.
Book Your MPN Panel Test Today
Take the first step toward accurate diagnosis and personalized treatment for blood disorders. Our experienced team is ready to assist you with scheduling your Myeloproliferative Neoplasia MPN Panel test. Contact us today to book your appointment or speak with our genetic counseling specialists.
Call or WhatsApp: +1(267) 388-9828
Note: This test typically requires a doctor’s prescription. However, prescriptions are not applicable for surgery preparation, pregnancy cases, or individuals planning international travel. Please consult with our staff regarding specific requirements for your situation.
