MSH6 Gene Endometrial Cancer Familial MSH6 Related NGS Genetic DNA Test
Comprehensive Genetic Testing for Hereditary Endometrial Cancer Risk
The MSH6 Gene Endometrial Cancer NGS Genetic DNA Test represents a cutting-edge approach to identifying individuals at increased risk for hereditary endometrial cancer through advanced next-generation sequencing technology. This specialized test focuses on the MSH6 gene, a critical component of the DNA mismatch repair system that plays a vital role in maintaining genomic stability and preventing cancer development.
What Does the MSH6 Gene Test Measure?
This comprehensive genetic analysis specifically targets the MSH6 gene to detect mutations associated with Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). The test utilizes sophisticated NGS technology to examine:
- Point mutations and small insertions/deletions in the MSH6 gene
- Large genomic rearrangements affecting MSH6 function
- Pathogenic variants that disrupt DNA mismatch repair mechanisms
- Inherited genetic changes passed through family generations
Who Should Consider MSH6 Genetic Testing?
This test is particularly important for individuals who meet any of the following criteria:
- Personal history of endometrial cancer diagnosed before age 50
- Family history of endometrial, colorectal, or other Lynch syndrome-associated cancers
- Multiple primary cancers in the same individual
- Endometrial cancer with abnormal mismatch repair protein expression
- First-degree relatives of individuals with known MSH6 mutations
- Individuals from families meeting Amsterdam II criteria for Lynch syndrome
Clinical Benefits of MSH6 Genetic Testing
Undergoing MSH6 genetic testing provides numerous advantages for cancer risk management:
- Personalized Cancer Surveillance: Enables tailored screening protocols based on individual genetic risk
- Early Detection Opportunities: Facilitates proactive monitoring for Lynch syndrome-associated cancers
- Informed Family Planning: Provides crucial information for reproductive decisions and family risk assessment
- Targeted Prevention Strategies: Supports implementation of evidence-based risk reduction measures
- Treatment Guidance: May influence therapeutic decisions for cancer patients with MSH6 mutations
Understanding Your Test Results
Your MSH6 genetic test results will fall into one of several categories:
- Positive Result: Indicates the presence of a pathogenic MSH6 mutation, confirming Lynch syndrome diagnosis and necessitating enhanced cancer surveillance
- Negative Result: No mutation detected in the MSH6 gene, though other genetic factors may still contribute to cancer risk
- Variant of Uncertain Significance (VUS): Identifies a genetic change with unknown clinical implications, requiring ongoing research and family studies
- No Mutation Detected in Affected Individual: May suggest alternative genetic causes or sporadic cancer development
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Test Details:
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Methodology: Next-Generation Sequencing (NGS) Technology
- Specialty: Oncology Genetics
Pre-Test Requirements
Before undergoing MSH6 genetic testing, patients should complete:
- Comprehensive clinical history documentation
- Genetic counseling session with a qualified genetics professional
- Development of detailed pedigree chart documenting family cancer history
- Informed consent process discussing test implications and potential outcomes
Nationwide Testing Availability
We proudly offer MSH6 genetic testing services across the United States with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified genetic counselors and healthcare professionals ensures accessible, high-quality genetic testing services nationwide.
Take Control of Your Genetic Health
Understanding your genetic predisposition to endometrial cancer can be life-changing. The MSH6 Gene Endometrial Cancer NGS Genetic DNA Test provides the clarity needed to make informed healthcare decisions and implement proactive cancer prevention strategies. Our team of genetic specialists is ready to guide you through the testing process and help interpret your results within the context of your personal and family medical history.
Ready to learn more about your genetic cancer risk? Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and MSH6 testing appointment.
