Methylguanine Methyltransferase MGMT Test
Understanding the MGMT Test for Brain Cancer Treatment
The Methylguanine Methyltransferase (MGMT) test represents a groundbreaking advancement in personalized cancer medicine, specifically designed for patients diagnosed with glioblastoma multiforme and other malignant brain tumors. This sophisticated molecular diagnostic evaluation plays a pivotal role in determining optimal treatment strategies by analyzing the epigenetic status of the MGMT gene promoter region.
What Does the MGMT Test Measure?
The MGMT test specifically detects and quantifies the methylation status of the O6-methylguanine-DNA methyltransferase gene promoter. This critical assessment reveals whether the DNA repair enzyme responsible for reversing chemotherapy-induced DNA damage has been epigenetically silenced through promoter methylation.
- MGMT promoter methylation analysis
- DNA repair enzyme activity assessment
- Chemotherapy response prediction
- Epigenetic silencing evaluation
Who Should Consider MGMT Testing?
MGMT testing is particularly recommended for patients who have been diagnosed with specific neurological conditions and cancer types:
Primary Candidates Include:
- Patients newly diagnosed with glioblastoma multiforme
- Individuals with recurrent high-grade glioma
- Patients considering temozolomide chemotherapy
- Those requiring personalized treatment planning for brain tumors
- Individuals with treatment-resistant brain cancer
Clinical Benefits of MGMT Testing
Undergoing MGMT testing provides numerous clinical advantages that significantly impact treatment outcomes and patient quality of life:
Key Benefits:
- Personalized Treatment Planning: Enables oncologists to tailor chemotherapy regimens based on individual genetic profiles
- Improved Response Prediction: Accurately forecasts patient response to alkylating chemotherapy agents
- Enhanced Survival Outcomes: Patients with methylated MGMT promoters demonstrate significantly better survival rates with temozolomide treatment
- Reduced Treatment Toxicity: Helps avoid ineffective treatments and unnecessary side effects
- Informed Decision Making: Provides crucial information for patients and healthcare providers to make educated treatment choices
Understanding Your MGMT Test Results
Interpreting MGMT test results requires specialized medical expertise, but understanding the basic implications can help patients participate actively in their treatment decisions:
Result Interpretation Guide:
- MGMT Promoter Methylated: Indicates epigenetic silencing of the DNA repair gene, typically associated with better response to temozolomide chemotherapy and improved survival outcomes
- MGMT Promoter Unmethylated: Suggests active DNA repair capability, which may reduce chemotherapy effectiveness and warrant consideration of alternative treatment approaches
- Borderline Results: Some cases may show partial methylation, requiring careful clinical correlation and potentially repeat testing
MGMT Test Pricing and Availability
We offer comprehensive MGMT testing at competitive prices with convenient locations throughout the United States:
| Test Description | Price (USD) |
|---|---|
| Methylguanine Methyltransferase MGMT Test – Discount Price | $1500 |
| Methylguanine Methyltransferase MGMT Test – Regular Price | $2000 |
Test Specifications:
- Turnaround Time: Sample received by Monday 11 AM; Report delivered in 13 working days
- Sample Types: Blood, Buccal Swab, or Plasma
- Methodology: Advanced PCR-based analysis
- Pre-test Requirements: Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
Nationwide Testing Availability
Our comprehensive molecular diagnostics services are available across major metropolitan areas throughout the United States, including:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and the Midwest region
- Houston and Texas metropolitan areas
- Phoenix and Arizona locations
- Philadelphia and Eastern Pennsylvania
- San Antonio and South Texas
- San Diego and coastal California
- Dallas-Fort Worth metroplex
- San Jose and Silicon Valley
Take Control of Your Cancer Treatment Today
Don’t leave your treatment decisions to chance. The MGMT test provides critical information that can significantly impact your cancer treatment journey. Our expert molecular diagnostics team utilizes state-of-the-art PCR technology to deliver accurate, reliable results that empower you and your healthcare team to make informed decisions.
Ready to schedule your MGMT test? Contact our dedicated patient care team today to book your appointment or discuss your testing needs. Call or WhatsApp us at +1(267) 388-9828 to speak with a genetic counseling specialist who can answer your questions and help you take the next step in your personalized cancer treatment plan.
Take advantage of our current promotional pricing of $1500 USD and gain access to the advanced molecular insights that could transform your cancer treatment approach. Your journey toward personalized, effective cancer care begins with a single phone call.
