KRT16 Gene Palmoplantar Keratoderma Nonepidermolytic Focal NGS Genetic DNA Test
Comprehensive Genetic Testing for Palmoplantar Keratoderma
The KRT16 Gene Palmoplantar Keratoderma Nonepidermolytic Focal NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for dermatological conditions. This advanced test specifically targets mutations in the KRT16 gene, which plays a critical role in keratin formation and skin integrity. Palmoplantar keratoderma is a rare genetic disorder characterized by abnormal thickening of the skin on the palms of hands and soles of feet, significantly impacting quality of life and requiring precise diagnosis for effective management.
What Does This Test Detect?
This sophisticated genetic analysis utilizes Next-Generation Sequencing (NGS) technology to identify specific mutations in the KRT16 gene that cause focal nonepidermolytic palmoplantar keratoderma. The test examines:
- Point mutations in the KRT16 gene coding regions
- Small insertions and deletions affecting gene function
- Genetic variations that disrupt keratin filament assembly
- Inheritance patterns and familial risk assessment
Who Should Consider This Genetic Test?
Clinical Indications and Symptoms
This test is recommended for individuals experiencing:
- Progressive thickening of skin on palms and soles
- Focal areas of hyperkeratosis without epidermolysis
- Family history of palmoplantar keratoderma
- Early-onset skin thickening in childhood or adolescence
- Pain or discomfort during walking or manual activities
- Recurrent fissures or cracks in thickened skin areas
- Limited response to conventional dermatological treatments
Significant Benefits of Genetic Testing
Undergoing the KRT16 genetic test provides numerous advantages:
- Accurate Diagnosis: Confirms the specific genetic cause of symptoms
- Personalized Treatment: Enables targeted therapeutic approaches
- Family Planning: Provides crucial information for genetic counseling
- Early Intervention: Facilitates proactive management strategies
- Peace of Mind: Reduces diagnostic uncertainty and anxiety
- Comprehensive Care: Integrates dermatology and genetics for holistic treatment
Understanding Your Test Results
Our genetic specialists provide comprehensive interpretation of your results:
- Positive Result: Indicates presence of KRT16 gene mutation, confirming diagnosis
- Negative Result: Suggests absence of tested mutations, though other genetic causes may exist
- Variant of Unknown Significance: Requires further clinical correlation and family studies
- Carrier Status: Identifies individuals who may pass the condition to offspring
All results include detailed genetic counseling to help you understand implications and next steps.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | KRT16 Gene Palmoplantar Keratoderma Nonepidermolytic Focal NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements
Before testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session with our specialists
- Family pedigree chart creation for affected members
- Discussion of testing implications and expectations
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality genetic analysis regardless of your location.
Take the Next Step Toward Genetic Clarity
Don’t let uncertainty about your dermatological condition affect your quality of life. Our specialized genetic testing provides the answers you need for proper diagnosis and effective treatment planning. Our team of genetic counselors and dermatology specialists are ready to guide you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic test consultation and take control of your dermatological health.
