Immunohistochemistry p63 Test: Advanced Cancer Detection and Diagnosis
Understanding the Immunohistochemistry p63 Test
The Immunohistochemistry p63 Test represents a cutting-edge diagnostic approach in modern oncology, utilizing sophisticated laboratory techniques to detect specific protein markers in tissue samples. This specialized test focuses on identifying the p63 protein, a crucial nuclear transcription factor that plays a vital role in cellular differentiation and development. As a member of the p53 protein family, p63 serves as an essential marker for basal and myoepithelial cells, making it particularly valuable in cancer diagnosis and classification.
What Does the p63 Test Measure?
The Immunohistochemistry p63 Test specifically detects the presence and distribution of p63 protein within tissue samples. This protein marker is primarily expressed in:
- Basal cells of various epithelial tissues
- Myoepithelial cells in breast and salivary gland tissues
- Prostate basal cells
- Squamous cell carcinomas
Clinical Importance and Applications
The p63 test holds significant clinical importance in modern cancer diagnostics, particularly in distinguishing between different types of malignancies and ensuring accurate tumor classification. Its primary applications include:
Prostate Cancer Diagnosis
In prostate pathology, the p63 test is invaluable for differentiating prostate adenocarcinoma from benign conditions. Since prostate adenocarcinomas typically lack basal cells, the absence of p63 staining helps confirm malignant diagnosis, while positive staining suggests benign prostatic hyperplasia or other non-malignant conditions.
Breast Cancer Evaluation
For breast tissue analysis, p63 serves as a reliable marker for myoepithelial cells. The presence of p63-positive myoepithelial cells helps distinguish invasive carcinomas from in-situ lesions, providing critical information for treatment planning and prognosis assessment.
Head and Neck Cancers
In head and neck pathology, p63 is extensively used to identify squamous cell carcinomas and distinguish them from other histological types, ensuring appropriate therapeutic interventions.
Who Should Consider This Test?
The Immunohistochemistry p63 Test is recommended for patients with:
- Suspected prostate cancer based on elevated PSA levels or abnormal digital rectal exam
- Breast lesions requiring precise classification and differentiation
- Head and neck masses of unknown origin
- Lung nodules or masses requiring histological characterization
- Previous inconclusive biopsy results requiring additional marker analysis
- Monitoring treatment response in known cancer cases
Key Benefits of the p63 Test
Choosing the Immunohistochemistry p63 Test offers numerous advantages for accurate cancer diagnosis and management:
Enhanced Diagnostic Accuracy
The test provides precise identification of basal cell markers, significantly reducing diagnostic uncertainty and ensuring appropriate treatment pathways.
Comprehensive Cancer Profiling
By detecting specific cellular markers, the test contributes to comprehensive tumor characterization, enabling personalized treatment approaches.
Early Detection Capabilities
The sensitivity of immunohistochemistry allows for early detection of malignant changes, potentially improving treatment outcomes and survival rates.
Therapeutic Guidance
Accurate classification of tumor types directly influences treatment decisions, ensuring patients receive the most appropriate therapeutic interventions.
Understanding Your Test Results
Interpreting p63 test results requires professional medical expertise, but general guidance includes:
Positive p63 Staining
Positive results typically indicate the presence of basal or myoepithelial cells, which may suggest:
- Benign prostatic conditions in prostate tissue
- Preservation of myoepithelial layer in breast lesions (suggesting in-situ rather than invasive carcinoma)
- Squamous differentiation in various tissues
Negative p63 Staining
Negative results, particularly in prostate tissue, often indicate:
- Prostate adenocarcinoma (due to loss of basal cells)
- Invasive carcinoma in breast tissue
- Certain types of glandular malignancies
Consultation Required
All test results should be discussed with your healthcare provider, who will interpret them in the context of your complete clinical picture, including symptoms, imaging findings, and other laboratory results.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $76 |
| Regular Price | $112 |
Nationwide Availability
GGC DNA provides comprehensive testing services across the United States, with branches in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network ensures convenient access to advanced diagnostic testing regardless of your location.
Sample Requirements and Processing
For accurate p63 testing, please provide:
- Tumor tissue preserved in 10% formal-saline OR formalin-fixed paraffin-embedded block
- Ship samples at room temperature with proper packaging
- Include complete clinical documentation: Histopathology report, biopsy site information, and detailed clinical history
Turnaround Times
- Block samples: 5 days
- Tissue biopsy: 5 days
- Large complex tissue: 7 days
- Sample acceptance: Daily by 6 PM
Take Action for Your Health Today
Don’t leave your health to chance. The Immunohistochemistry p63 Test provides critical information for accurate cancer diagnosis and treatment planning. Our team of experienced oncologists and pathologists is ready to assist you with comprehensive diagnostic services.
Book your Immunohistochemistry p63 Test today by calling +1(267) 388-9828 or schedule your appointment through our online booking system. Take the first step toward precise diagnosis and effective treatment with GGC DNA’s advanced cancer diagnostics.
