Immunohistochemistry Cyclin D1 Test: Advanced Cancer Cell Cycle Analysis
Comprehensive Introduction to Cyclin D1 Testing
The Immunohistochemistry Cyclin D1 Test represents a cutting-edge diagnostic approach in modern oncology, providing critical insights into cell cycle regulation and cancer development. Cyclin D1 is a key regulatory protein that controls the transition from G1 to S phase in the cell cycle, and its abnormal expression is strongly associated with various malignancies. This specialized test utilizes immunohistochemistry (IHC) techniques to detect Cyclin D1 protein expression in tissue samples, offering valuable information for cancer diagnosis, classification, and treatment planning.
At General Genetics Corporation, we understand the importance of accurate cancer diagnostics. Our Immunohistochemistry Cyclin D1 Test provides healthcare professionals with reliable, clinically validated results that directly impact patient care decisions. The test’s ability to identify specific molecular markers makes it an indispensable tool in the era of precision medicine and targeted cancer therapies.
What Does the Cyclin D1 Test Measure?
The Immunohistochemistry Cyclin D1 Test specifically detects and quantifies the presence of Cyclin D1 protein in tissue specimens. This sophisticated analysis provides:
- Protein Expression Levels: Measures the intensity and distribution of Cyclin D1 protein within tumor cells
- Nuclear Localization: Identifies Cyclin D1 accumulation in cell nuclei, indicating active cell cycle progression
- Overexpression Patterns: Detects abnormal Cyclin D1 levels that suggest dysregulated cell cycle control
- Tumor Classification: Helps differentiate between various cancer types based on molecular characteristics
The test employs specific antibodies that bind to Cyclin D1 proteins, followed by visualization techniques that allow pathologists to assess protein expression patterns under microscopic examination. This method provides both qualitative and semi-quantitative data essential for comprehensive cancer evaluation.
Clinical Indications: Who Should Consider This Test?
Primary Diagnostic Applications
The Immunohistochemistry Cyclin D1 Test is particularly valuable for patients presenting with:
- Suspected Mantle Cell Lymphoma: Essential for confirming diagnosis when lymph node biopsies show characteristic features
- Breast Cancer Evaluation: Important for assessing hormone receptor status and treatment response prediction
- Multiple Myeloma Workup: Helps identify specific genetic abnormalities associated with disease progression
- Head and Neck Cancers: Useful in squamous cell carcinoma characterization and prognosis assessment
- Unclassified Lymphomas: Assists in differential diagnosis when standard morphological features are ambiguous
Symptom-Based Considerations
Patients experiencing the following symptoms may benefit from Cyclin D1 testing:
- Unexplained lymph node enlargement or swelling
- Persistent fatigue and unexplained weight loss
- Abnormal bleeding or bruising tendencies
- Bone pain or pathological fractures
- Recurrent infections or immune system abnormalities
- Breast lumps or abnormal mammogram findings
Significant Benefits of Cyclin D1 Testing
Choosing the Immunohistochemistry Cyclin D1 Test provides numerous advantages for both patients and healthcare providers:
- Precise Diagnosis: Enables accurate classification of cancer subtypes, particularly in hematological malignancies
- Treatment Guidance: Informs targeted therapy decisions based on specific molecular markers
- Prognostic Information: Provides insights into disease aggressiveness and potential treatment responses
- Minimized Misdiagnosis: Reduces the risk of incorrect cancer classification and inappropriate treatment
- Personalized Medicine: Supports development of individualized treatment strategies
- Monitoring Capabilities: Allows assessment of treatment effectiveness and disease progression
Understanding Your Test Results
Interpretation Guidelines
Cyclin D1 test results are typically reported as follows:
- Positive Result: Indicates Cyclin D1 protein overexpression, commonly associated with mantle cell lymphoma, certain breast cancers, and other malignancies
- Negative Result: Suggests normal Cyclin D1 expression levels, though clinical correlation with other diagnostic findings is essential
- Focal Positivity: May indicate heterogeneous tumor populations or early disease stages
- Nuclear Staining Pattern: Confirms functional protein localization and active cell cycle involvement
Clinical Correlation
It’s crucial to understand that Cyclin D1 test results should always be interpreted in the context of:
- Complete clinical history and physical examination findings
- Other laboratory and imaging studies
- Tissue morphology and additional immunohistochemical markers
- Genetic testing results when available
Your healthcare provider will integrate Cyclin D1 findings with comprehensive clinical data to establish an accurate diagnosis and develop an appropriate treatment plan.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $88 |
| Regular Price | $126 |
Turnaround Time
- Sample Submission: Daily by 6 PM
- Report for Tissue Block: 5 days
- Report for Tissue Biopsy: 5 days
- Report for Large Complex Tissue: 7 days
Sample Requirements
For accurate testing, please submit:
- Tumor tissue preserved in 10% formal-saline OR formalin-fixed paraffin-embedded block
- Ship samples at room temperature with appropriate packaging
- Include complete documentation: Histopathology report, biopsy site information, and clinical history
Nationwide Accessibility
General Genetics Corporation maintains comprehensive testing facilities across the United States, with branches conveniently located in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our nationwide network ensures that patients and healthcare providers have access to advanced diagnostic services regardless of location.
Take Action for Your Health
Don’t delay critical cancer diagnosis and treatment planning. The Immunohistochemistry Cyclin D1 Test provides essential information that can significantly impact your healthcare journey. Our team of experienced oncologists and pathologists is ready to assist you with comprehensive testing and expert result interpretation.
Book your Immunohistochemistry Cyclin D1 Test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your appointment through our online booking system. Take the first step toward precise cancer diagnosis and personalized treatment planning.
