Immunohistochemistry Calretinin Test: Advanced Cancer Detection and Diagnosis
Understanding the Immunohistochemistry Calretinin Test
The Immunohistochemistry Calretinin Test represents a cutting-edge diagnostic approach in modern pathology, specifically designed to detect the presence of calretinin protein within tissue samples. This sophisticated laboratory technique utilizes specialized antibodies that bind specifically to calretinin, creating visible markers that pathologists can analyze under microscopy. The test’s primary importance lies in its ability to provide definitive cellular-level information that significantly enhances cancer diagnosis accuracy and treatment planning.
Calretinin, a calcium-binding protein primarily expressed in mesothelial cells, serves as a crucial biomarker for distinguishing between different types of cancers, particularly those affecting the lining of body cavities. The test’s precision in identifying cellular origins makes it an indispensable tool in oncological pathology, helping clinicians make informed decisions about patient management and therapeutic interventions.
What the Test Measures and Detects
The Immunohistochemistry Calretinin Test specifically measures the presence and distribution of calretinin protein within tissue specimens. This advanced diagnostic procedure detects:
- Mesothelial cell differentiation in tumors
- Presence of mesothelioma cells in pleural and peritoneal tissues
- Distinction between mesothelioma and adenocarcinoma
- Cellular origin of metastatic tumors
- Protein expression patterns in various cancer types
The test produces characteristic staining patterns that experienced pathologists interpret to determine whether cells are of mesothelial origin. Positive calretinin staining typically appears as nuclear and cytoplasmic brown coloration, providing clear visual evidence of mesothelial differentiation that guides accurate diagnosis.
Who Should Consider This Test
Several patient populations benefit significantly from the Immunohistochemistry Calretinin Test, particularly those presenting with:
- Unexplained pleural effusions or peritoneal fluid accumulation
- Suspected mesothelioma based on imaging studies
- Undifferentiated tumors requiring precise classification
- History of asbestos exposure with concerning symptoms
- Persistent chest pain, shortness of breath, or abdominal discomfort
- Unexplained weight loss with respiratory symptoms
- Previous inconclusive biopsy results requiring further characterization
Oncologists and pathologists typically recommend this test when initial pathology results are ambiguous or when specific tumor differentiation is necessary for treatment planning. Patients with occupational asbestos exposure history should particularly consider this test as part of their diagnostic evaluation.
Key Benefits of Taking the Test
The Immunohistochemistry Calretinin Test offers numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Provides definitive identification of mesothelioma and differentiation from other cancers
- Treatment Guidance: Informs appropriate treatment strategies based on precise tumor classification
- Prognostic Information: Helps assess disease progression and patient outlook
- Early Detection: Enables timely intervention for better treatment outcomes
- Comprehensive Analysis: Complements other diagnostic methods for complete evaluation
- Cost-Effective: Affordable testing at only $76 USD provides significant diagnostic value
Understanding Your Test Results
Interpreting Immunohistochemistry Calretinin Test results requires professional medical expertise, but general guidance includes:
- Positive Result: Indicates presence of calretinin, suggesting mesothelial origin – typically associated with mesothelioma
- Negative Result: Absence of calretinin staining suggests non-mesothelial tumors such as adenocarcinoma
- Focal Positivity: Partial staining may indicate mixed tumor types requiring additional evaluation
- Interpretation Context: Results are always considered alongside clinical history and other diagnostic findings
Your healthcare provider will explain your specific results in detail, discussing implications for diagnosis and treatment planning. Remember that test interpretation considers multiple factors, and final diagnosis integrates all available clinical information.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $76 |
| Regular Price | $112 |
Turnaround Time
- Sample Daily by 6 pm
- Report Block: 5 days
- Tissue Biopsy: 5 days
- Tissue Large Complex: 7 days
Sample Requirements
Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, with branches in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our nationwide network ensures convenient access to advanced cancer diagnostics regardless of your location.
Book Your Test Today
Take the first step toward accurate cancer diagnosis and appropriate treatment planning. Our expert team of pathologists and oncologists is ready to provide you with the precise diagnostic information you need.
Call or WhatsApp: +1(267) 388-9828 to schedule your Immunohistochemistry Calretinin Test and benefit from our discounted pricing of only $76 USD. Early and accurate diagnosis can significantly impact treatment success and patient outcomes.
