Immunohistochemistry BCL6 Test
Comprehensive Introduction to BCL6 Testing
The Immunohistochemistry BCL6 Test represents a cutting-edge diagnostic approach in modern oncology, specifically designed to detect the presence and distribution of BCL6 protein within tissue samples. BCL6 (B-cell lymphoma 6) is a crucial transcriptional regulator that plays a significant role in B-cell development and differentiation. When dysregulated, this protein becomes a key biomarker for various types of lymphomas, making its detection essential for accurate cancer diagnosis and classification.
This sophisticated test utilizes advanced immunohistochemistry techniques to visualize BCL6 protein expression patterns at the cellular level. The importance of this test cannot be overstated, as it provides oncologists and pathologists with critical information needed to distinguish between different lymphoma subtypes, predict disease behavior, and guide targeted treatment strategies. The test’s ability to precisely identify BCL6 expression patterns makes it an indispensable tool in the comprehensive evaluation of lymphoid malignancies.
What the BCL6 Test Measures and Detects
The Immunohistochemistry BCL6 Test specifically measures the presence, intensity, and distribution pattern of BCL6 protein within tissue specimens. This advanced diagnostic procedure detects:
- Nuclear expression of BCL6 protein in B-cells
- Patterns of protein distribution within tumor tissue
- Intensity of staining, which correlates with protein expression levels
- Cellular localization of BCL6 within the nucleus
- Percentage of positive cells within the tissue sample
The test employs specific antibodies that bind to BCL6 protein, followed by visualization using chromogenic substrates. This allows pathologists to precisely identify which cells express the protein and to what degree, providing valuable insights into the biological behavior of the lymphoma.
Who Should Consider the BCL6 Test
This specialized diagnostic test is recommended for patients presenting with specific clinical scenarios and symptoms:
Clinical Indications
- Patients with suspected or confirmed lymphoma diagnosis
- Individuals with enlarged lymph nodes of unknown origin
- Patients with B-cell lymphoma requiring subtyping
- Cases where diffuse large B-cell lymphoma (DLBCL) is suspected
- Patients with recurrent or refractory lymphoma
- Individuals needing prognostic assessment for treatment planning
Symptoms and Presentations
- Unexplained lymph node enlargement
- Night sweats and unexplained fever
- Unexplained weight loss
- Fatigue and general malaise
- Abdominal pain or fullness
- Chest pain or breathing difficulties
Significant Benefits of BCL6 Testing
Undergoing the Immunohistochemistry BCL6 Test offers numerous advantages for both patients and healthcare providers:
- Accurate Diagnosis: Provides precise identification of lymphoma subtypes
- Treatment Guidance: Helps determine the most effective therapeutic approaches
- Prognostic Information: Offers insights into disease behavior and potential outcomes
- Targeted Therapy: Enables selection of specific treatments based on molecular markers
- Monitoring Capability: Allows tracking of treatment response and disease progression
- Comprehensive Evaluation: Complements other diagnostic tests for complete assessment
Understanding Your Test Results
Interpreting BCL6 test results requires professional medical expertise, but here’s general guidance on what different findings may indicate:
Positive BCL6 Expression
A positive result typically shows nuclear staining in a significant percentage of tumor cells. This finding often correlates with germinal center B-cell-like (GCB) subtype of diffuse large B-cell lymphoma, which may have different treatment implications and prognosis compared to other subtypes.
Negative BCL6 Expression
Absence of BCL6 staining may suggest alternative lymphoma subtypes or different biological characteristics. Your oncologist will interpret this result in the context of other diagnostic findings and clinical presentation.
Interpretation Considerations
- Results are interpreted by board-certified pathologists
- Findings are correlated with other clinical and laboratory data
- Pattern and intensity of staining provide additional diagnostic information
- Results guide treatment decisions and prognostic assessment
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry BCL6 Test | $88 USD | $126 USD |
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, with branches in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and Charlotte. Our nationwide network ensures convenient access to advanced diagnostic testing regardless of your location.
Sample Requirements and Processing
Sample Type: Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature.
Required Documentation: Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Turnaround Time: Sample Daily by 6 pm; Report Block: 5 days; Tissue Biopsy: 5 days; Tissue large complex: 7 days
Take Action for Your Health
Don’t delay critical diagnostic testing. The Immunohistochemistry BCL6 Test provides essential information for accurate lymphoma diagnosis and treatment planning. Our experienced team of oncologists and pathologists are ready to assist you with comprehensive cancer diagnostic services.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your test or speak with our medical professionals. Take the first step toward precise diagnosis and effective treatment planning with GGC DNA’s advanced cancer diagnostics.
