HLA Pretransplant Workup Panel 2 Test
Comprehensive Introduction to HLA Pretransplant Testing
The HLA Pretransplant Workup Panel 2 represents a critical advancement in transplantation medicine, providing comprehensive immunological assessment essential for successful organ transplantation outcomes. This sophisticated diagnostic panel evaluates the compatibility between donor and recipient at the molecular level, focusing on human leukocyte antigens (HLA) that play a pivotal role in immune recognition and rejection responses.
Organ transplantation success heavily depends on proper HLA matching, as mismatched antigens can trigger devastating immune reactions leading to graft rejection. Our HLA Pretransplant Workup Panel 2 employs state-of-the-art technologies to deliver precise, reliable results that transplant teams rely on for making life-saving decisions.
What This Advanced Test Measures and Detects
The HLA Pretransplant Workup Panel 2 provides comprehensive analysis through multiple sophisticated methodologies:
Primary Detection Capabilities:
- HLA Class I and Class II antigen typing for precise donor-recipient matching
- Detection of pre-formed anti-HLA antibodies that could cause hyperacute rejection
- Crossmatch compatibility assessment using advanced flow cytometry techniques
- Identification of donor-specific antibodies (DSA) through Luminex technology
- Complement-dependent cytotoxicity evaluation with DTT treatment
Advanced Methodologies Employed:
- Complement Dependent Cytotoxicity with DTT treatment
- Reverse Sequence Specific Oligonucleotide Probe (SSOP) – Luminex
- Luminex X-Map multiplex technology for high-resolution typing
- Flow cytometry for sensitive antibody detection
Who Should Consider HLA Pretransplant Testing
This comprehensive panel is essential for specific patient populations undergoing transplantation evaluation:
Primary Candidates Include:
- Patients scheduled for kidney, liver, heart, or lung transplantation
- Individuals with end-stage renal disease awaiting kidney transplant
- Patients with previous transplant history requiring re-evaluation
- Candidates with known sensitization from blood transfusions or pregnancies
- Living donor-recipient pairs undergoing compatibility assessment
- Patients with autoimmune conditions affecting transplant eligibility
Clinical Indications:
- Pre-transplant immunological risk assessment
- Donor selection and matching optimization
- Identification of high immunological risk patients
- Evaluation of sensitization status post-transfusion or pregnancy
- Monitoring of immunological profile changes over time
Significant Benefits of HLA Pretransplant Testing
Undergoing comprehensive HLA testing provides numerous advantages for transplant candidates and their medical teams:
Clinical Benefits:
- Significantly reduces risk of acute and chronic rejection episodes
- Enables optimal donor selection for improved graft survival
- Identifies patients who may benefit from desensitization protocols
- Provides critical data for personalized immunosuppression regimens
- Minimizes post-transplant complications and hospitalizations
Patient-Centered Advantages:
- Increased confidence in transplant success rates
- Better long-term organ function and quality of life
- Reduced need for additional medical interventions
- Comprehensive understanding of immunological risks
- Informed decision-making regarding transplant timing
Understanding Your Test Results
Interpreting HLA Pretransplant Workup Panel 2 results requires specialized expertise, but here’s general guidance:
Key Result Components:
- HLA Typing Results: Identifies specific HLA antigens present in donor and recipient
- Antibody Screening: Detects pre-formed antibodies that could target donor tissue
- Crossmatch Results: Indicates immediate compatibility between donor and recipient
- Panel Reactive Antibody (PRA): Percentage of population against which patient has antibodies
- Donor Specific Antibodies (DSA): Antibodies specifically targeting donor HLA antigens
Result Interpretation Guidelines:
- Lower PRA percentages generally indicate better transplant candidacy
- Negative crossmatch results are essential for proceeding with transplantation
- HLA matching degree influences long-term graft survival
- Presence of DSA may require specialized treatment protocols
- Results should always be discussed with your transplant team
Test Pricing and Essential Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $716 |
| Regular Price | $796 |
| Turnaround Time | 10-12 days |
Sample Requirements:
Comprehensive sample collection is essential for accurate results:
- Recipient Samples Required:
- 6 mL (3 mL minimum) whole blood in 1 Yellow Top (ACD) tube
- 9 mL (6 mL minimum) serum from 3 SST tubes
- 4 mL (2 mL minimum) whole blood in 1 Lavender top (EDTA) tube
- 4 mL (2 mL minimum) whole blood in 1 Green Top (Sodium Heparin) tube
Critical Pre-Test Instructions:
- Collect specimens preferably 48 hours after dialysis sessions
- Maintain shipping temperature at 18-22°C during transport
- DO NOT refrigerate or freeze samples under any circumstances
- Doctor’s prescription on letterhead with 1 photograph each of recipient and donor duly stamped
- Consent form for HLA Typing for Solid organ transplant (Form 33) is mandatory
Nationwide Accessibility and Booking
GGC DNA maintains comprehensive testing facilities across the United States, ensuring convenient access to this critical pre-transplant evaluation. Our network includes specialized centers in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Philadelphia, Phoenix, San Antonio, San Diego, Dallas, and San Jose.
Each facility is equipped with state-of-the-art laboratory equipment and staffed by experienced transplantation immunology specialists. Our commitment to excellence ensures consistent, reliable results that transplant centers nationwide trust for critical patient care decisions.
Take the Next Step Toward Successful Transplantation
Don’t leave your transplant success to chance. Comprehensive HLA testing provides the immunological foundation necessary for optimal outcomes. Our expert team is ready to guide you through the testing process and ensure you receive the highest quality care.
Book your HLA Pretransplant Workup Panel 2 Test today by calling our dedicated transplantation specialists at +1(267) 388-9828 or schedule your appointment through our online booking system.
With rapid 10-12 day turnaround times and comprehensive result reporting, we provide the critical data your transplant team needs to make informed decisions about your care. Trust GGC DNA for accurate, reliable HLA testing that makes a difference in transplantation outcomes.
