HLA Cadaveric Crossmatch Test: Essential Pre-Transplant Compatibility Assessment
Understanding HLA Cadaveric Crossmatch Testing
The HLA Cadaveric Crossmatch Test represents a cornerstone of modern transplant medicine, providing critical immunological compatibility assessment between organ donors and potential recipients. This sophisticated laboratory procedure evaluates whether a recipient’s immune system contains pre-formed antibodies that could immediately attack and destroy a donor organ upon transplantation. The test’s importance cannot be overstated, as it serves as the final immunological barrier preventing hyperacute rejection – a devastating complication that can destroy a transplanted organ within minutes to hours.
What Does the HLA Cadaveric Crossmatch Measure?
This comprehensive test specifically detects donor-specific anti-HLA antibodies in the recipient’s serum that could react against donor lymphocytes. The procedure utilizes Complement Dependent Cytotoxicity with DTT treatment methodology, which provides enhanced sensitivity and specificity in antibody detection. The test evaluates:
- Presence of pre-formed anti-HLA antibodies against donor antigens
- Immunological compatibility between donor and recipient
- Risk assessment for hyperacute and acute rejection
- Cross-reactivity patterns that could impact transplant success
Who Should Consider HLA Cadaveric Crossmatch Testing?
This essential test is specifically designed for patients awaiting organ transplantation and is typically ordered by transplant specialists including nephrologists and gastroenterologists. The test is crucial for:
- Patients on transplant waiting lists for kidneys, livers, hearts, or other organs
- Individuals with previous blood transfusions or pregnancies
- Patients with prior transplant history
- Recipients with known sensitization to HLA antigens
- Emergency transplant candidates requiring rapid compatibility assessment
Clinical Benefits of HLA Crossmatch Testing
Undergoing HLA Cadaveric Crossmatch testing provides numerous critical benefits for transplant candidates:
- Prevention of Hyperacute Rejection: Identifies incompatible donor-recipient pairs before transplantation
- Improved Transplant Success Rates: Ensures immunological compatibility for better long-term outcomes
- Personalized Transplant Planning: Allows for tailored immunosuppression protocols
- Risk Stratification: Helps identify patients who may require specialized treatment approaches
- Time-Sensitive Decision Making: Provides rapid results crucial for cadaveric organ allocation
Understanding Your Test Results
Interpreting HLA Cadaveric Crossmatch results requires specialized medical expertise. Generally, results fall into these categories:
- Negative Crossmatch: Indicates no detectable donor-specific antibodies, suggesting immunological compatibility and proceeding with transplantation
- Positive Crossmatch: Signals presence of donor-specific antibodies, indicating high risk for rejection and typically contraindicating transplantation
- Weakly Positive Results: May require additional testing and specialized interpretation by transplant immunologists
Your transplant team will provide detailed interpretation and discuss implications for your specific clinical situation.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| HLA Cadaveric Crossmatch Test | $68 USD | $300 USD |
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, with specialized transplant immunology laboratories in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our network ensures rapid specimen processing and reliable results within the standard 10-12 day turnaround time.
Specimen Requirements and Collection Guidelines
Proper specimen collection is essential for accurate test results:
- Recipient Specimen: 6 mL (3 mL minimum) whole blood in 1 Yellow Top (ACD) tube AND 3 mL (2 mL minimum) serum from 1 SST tube
- Cadaveric Donor Specimen: 12 mL (10 mL minimum) whole blood in 2 Yellow Top (ACD) tubes
- Collection Timing: Collect recipient specimen preferably 48 hours after dialysis
- Shipping Instructions: Ship refrigerated – DO NOT FREEZE
- Required Documentation: Doctor’s prescription on letterhead with stamp AND photograph of recipient is mandatory
Take the Next Step Toward Successful Transplantation
Don’t leave your transplant success to chance. The HLA Cadaveric Crossmatch Test provides the critical immunological information needed to ensure your transplant journey begins with the best possible foundation. Our experienced team understands the urgency and importance of transplant compatibility testing and is committed to providing accurate, timely results.
Ready to schedule your HLA Cadaveric Crossmatch Test? Contact our transplant testing specialists today at +1(267) 388-9828 or book your appointment online. Our dedicated team is available to answer your questions and guide you through the testing process, ensuring you receive the comprehensive care and accurate results essential for your transplant journey.
