FISH NTRK 1-2-3 Gene Panel Test: Advanced Cancer Genetic Analysis

Comprehensive Introduction to NTRK Gene Fusion Testing

The FISH NTRK 1-2-3 Gene Panel Test represents a breakthrough in precision oncology, offering detailed molecular analysis of three critical neurotrophic tyrosine receptor kinase genes. This advanced diagnostic tool utilizes Fluorescence In Situ Hybridization (FISH) technology to detect gene rearrangements that drive cancer progression and can be targeted with specific therapeutic agents.

Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare but clinically significant molecular alterations that occur across various cancer types. When these genes fuse with other partner genes, they create constitutively active TRK fusion proteins that promote uncontrolled cell growth and tumor development. The identification of these fusions has revolutionized cancer treatment, as they serve as predictive biomarkers for TRK inhibitor therapies.

What the Test Measures and Detects

The FISH NTRK 1-2-3 Gene Panel Test specifically analyzes three key genetic regions:

• NTRK1 (1q21.3): Detects rearrangements in the neurotrophic tyrosine receptor kinase 1 gene
• NTRK2 (9q21.3): Identifies alterations in the neurotrophic tyrosine receptor kinase 2 gene
• NTRK3 (15q25.3): Screens for fusions in the neurotrophic tyrosine receptor kinase 3 gene

This comprehensive panel utilizes dual-color break-apart FISH probes to identify chromosomal rearrangements that lead to NTRK gene fusions. The test examines formalin-fixed paraffin-embedded (FFPE) tissue samples, making it compatible with standard pathology specimens and enabling retrospective analysis of archived tissue blocks.

Who Should Consider This Test

Clinical Indications and Patient Profiles

The FISH NTRK 1-2-3 Gene Panel Test is particularly valuable for patients with:

• Pediatric solid tumors with uncertain histology
• Secretory breast carcinoma
• Infantile fibrosarcoma
• Congenital mesoblastic nephroma
• Papillary thyroid cancer
• Gliomas and other central nervous system tumors
• Soft tissue sarcomas with spindle cell morphology
• Cancers with unknown primary origin
• Patients who have exhausted conventional treatment options

Symptoms and Clinical Scenarios

Consider this test when patients present with:

• Rare or unusual cancer subtypes
• Metastatic disease with limited treatment options
• Family history of cancer with potential genetic predisposition
• Younger patients with aggressive cancer presentations
• Cancers that have shown resistance to standard therapies

Benefits of Taking the FISH NTRK Gene Panel Test

This advanced genetic testing offers numerous clinical advantages:

• Personalized Treatment Planning: Identifies patients who may benefit from targeted TRK inhibitor therapies
• Comprehensive Molecular Profiling: Simultaneously analyzes all three NTRK genes for complete assessment
• High Sensitivity and Specificity: FISH technology provides reliable detection of gene rearrangements
• Treatment Guidance: Helps oncologists select appropriate targeted therapies based on molecular findings
• Prognostic Information: Provides insights into disease behavior and potential treatment response
• Cost-Effective Precision Medicine: Priced at only $438 USD, making advanced genetic testing accessible

Understanding Your Test Results

Interpretation Guidelines

Your FISH NTRK 1-2-3 Gene Panel Test results will provide critical information about gene fusion status:

Positive Result Interpretation

• NTRK Gene Fusion Detected: Indicates the presence of a chromosomal rearrangement involving one of the NTRK genes
• Clinical Significance: Positive results suggest potential eligibility for TRK inhibitor targeted therapy
• Treatment Implications: May qualify for FDA-approved TRK inhibitors like larotrectinib or entrectinib

Negative Result Interpretation

• No NTRK Fusion Detected: Indicates absence of detectable NTRK gene rearrangements
• Clinical Considerations: Negative results help exclude NTRK fusion-driven cancers
• Next Steps: May warrant consideration of alternative molecular testing or treatment approaches

Technical Considerations

• Results are interpreted by board-certified molecular pathologists
• Test sensitivity accounts for tumor heterogeneity and sample quality
• Results should be correlated with clinical findings and other diagnostic information

Test Pricing and Availability

Test Specifications

• Turnaround Time: Sample accepted daily by 6 pm; Report delivered in 4 working days
• Sample Type: Formalin fixed paraffin embedded tissue block or three 4 micron sections on Poly L Lysine coated slides
• Shipping Requirements: Ship at room temperature with completed Genomics Clinical Information Requisition Form (Form 20)
• Methodology: Fluorescence In Situ Hybridization (FISH)
• Specialty: Oncologist
• Department: Cytogenetics

Nationwide Testing Availability

GGC DNA provides comprehensive FISH NTRK 1-2-3 Gene Panel testing services across the United States. We have established branches in all major metropolitan areas including:

• New York City and surrounding regions
• Los Angeles and Southern California
• Chicago and the Midwest
• Houston and Texas medical centers
• Phoenix and Southwest regions
• All other major cities nationwide

Our network of certified laboratories ensures consistent quality and rapid turnaround times regardless of your location. We work closely with healthcare providers to facilitate seamless testing processes and timely result delivery.

Take Action Today: Book Your Test

Don’t wait to access this critical genetic information that could transform your cancer treatment journey. Our team of genetic specialists and oncology experts are ready to assist you with:

• Comprehensive test ordering and sample collection guidance
• Insurance pre-authorization support when applicable
• Result interpretation and clinical correlation
• Coordination with your healthcare team

Call or WhatsApp us today at +1(267) 388-9828 to schedule your FISH NTRK 1-2-3 Gene Panel Test. Our genetic counselors are available to answer your questions and help you understand how this advanced testing can benefit your specific clinical situation.

Take the first step toward personalized cancer care with GGC DNA’s comprehensive genetic testing services. Our commitment to precision medicine and patient-centered care ensures you receive the highest quality diagnostic information to guide your treatment decisions.