Estriol Unconjugated Free E3 Test: Comprehensive Prenatal Screening
Understanding the Estriol Unconjugated Free E3 Test
The Estriol Unconjugated Free E3 Test represents a cornerstone of modern prenatal care, offering crucial insights into fetal development and maternal health during pregnancy. This specialized blood test measures the levels of unconjugated estriol, a specific form of estrogen produced primarily by the placenta and fetal adrenal glands. As pregnancy progresses, estriol levels naturally increase, making this hormone an excellent biomarker for assessing fetal-placental function and overall pregnancy health.
This test plays a vital role in contemporary obstetric practice, providing healthcare providers with essential data to monitor fetal well-being and identify potential complications early in pregnancy. The measurement of unconjugated estriol has become particularly significant in screening programs designed to detect chromosomal abnormalities and other fetal conditions that may require specialized care or intervention.
What Does the Test Measure?
The Estriol Unconjugated Free E3 Test specifically quantifies the concentration of unconjugated (free) estriol in maternal blood serum. Unlike conjugated estriol, which is bound to proteins and less biologically active, unconjugated estriol represents the active form that crosses the placental barrier and provides direct information about fetal adrenal function and placental health.
Key Measurements Include:
- Unconjugated estriol concentration in nanograms per milliliter (ng/mL)
- Assessment of fetal adrenal gland function
- Evaluation of placental steroidogenesis capacity
- Integration with other maternal serum markers for comprehensive risk assessment
Who Should Consider This Test?
The Estriol Unconjugated Free E3 Test is recommended for various groups of pregnant women, particularly those with specific risk factors or clinical indications that warrant closer monitoring of fetal development.
Primary Candidates Include:
- Women with advanced maternal age (35 years or older)
- Pregnancies with abnormal ultrasound findings
- Patients with personal or family history of chromosomal abnormalities
- Women experiencing high-risk pregnancy conditions
- Patients undergoing routine second-trimester screening
- Those with previous pregnancies affected by neural tube defects
- Women with diabetes or other medical conditions affecting pregnancy
Clinical Benefits and Importance
Undergoing the Estriol Unconjugated Free E3 Test offers numerous advantages for both expectant mothers and healthcare providers, facilitating informed decision-making and proactive pregnancy management.
Key Benefits:
- Early Risk Assessment: Provides early detection of potential fetal abnormalities
- Comprehensive Screening: Part of integrated prenatal screening protocols
- Non-Invasive Procedure: Simple blood draw with minimal discomfort
- Timely Results: Daily turnaround ensures prompt clinical decision-making
- Guided Management: Helps determine need for additional diagnostic procedures
- Peace of Mind: Offers reassurance about fetal development and health
Understanding Your Test Results
Interpreting Estriol Unconjugated Free E3 Test results requires professional medical expertise, as values are typically assessed in conjunction with other screening markers and clinical factors.
General Interpretation Guidelines:
- Normal Range: Expected estriol levels vary by gestational age, with steady increases throughout pregnancy
- Low Levels: May indicate increased risk for chromosomal abnormalities or placental insufficiency
- Elevated Levels: Generally associated with normal fetal development and placental function
- Risk Calculation: Results are often expressed as multiples of the median (MoM) for age-specific comparisons
- Integrated Assessment: Combined with AFP and hCG measurements for comprehensive risk evaluation
It’s crucial to discuss your specific results with your healthcare provider, who can provide personalized interpretation based on your complete medical history, gestational age, and other relevant factors.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $36 |
| Regular Price | $40 |
Test Specifications:
- Test Name: Estriol Unconjugated Free E3 Test
- Sample Requirement: 2 mL (1 mL minimum) serum from 1 SST
- Shipping Instructions: Ship refrigerated or frozen
- Turnaround Time: Daily results
- Preparation: No special preparation required
- Testing Method: Chemiluminescent Immunoassay
Nationwide Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas. Our network includes specialized collection centers in:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and the Midwest region
- Houston and Texas metropolitan areas
- Miami and South Florida
- San Francisco Bay Area
- Boston and New England
- Seattle and Pacific Northwest
Each facility maintains the highest standards of clinical excellence, ensuring accurate results and professional patient care.
Take Action for Your Prenatal Health
Don’t leave your prenatal health to chance. The Estriol Unconjugated Free E3 Test provides essential information that can significantly impact your pregnancy management and peace of mind. Our experienced team is ready to assist you with convenient scheduling, professional sample collection, and comprehensive result interpretation.
Ready to schedule your test? Contact us today at +1(267) 388-9828 to book your appointment or speak with our prenatal screening specialists. We’re available to answer your questions and help you take the next step in ensuring optimal fetal health and development.
Take advantage of our current promotional pricing at only $36 USD and experience the confidence that comes with comprehensive prenatal screening from a trusted healthcare provider.

