DOCK8 Gene Hyper-IgE Recurrent Infection Syndrome Autosomal Recessive NGS Genetic DNA Test
Comprehensive Genetic Analysis for Immune System Disorders
The DOCK8 Gene Hyper-IgE Recurrent Infection Syndrome NGS Genetic DNA Test represents a cutting-edge diagnostic approach for identifying autosomal recessive mutations in the DOCK8 gene, which plays a critical role in immune system regulation. This specialized genetic test utilizes advanced next-generation sequencing technology to provide comprehensive analysis of the DOCK8 gene, enabling accurate detection of mutations associated with Hyper-IgE syndrome—a rare primary immunodeficiency disorder characterized by elevated immunoglobulin E levels and recurrent infections.
What This Test Measures and Detects
Our NGS-based genetic test specifically targets the DOCK8 (Dedicator of Cytokinesis 8) gene, which encodes a protein essential for proper immune cell function and signaling. The test identifies:
- Point mutations, deletions, and insertions in the DOCK8 gene
- Autosomal recessive inheritance patterns
- Pathogenic variants affecting immune cell migration and function
- Genetic markers associated with severe combined immunodeficiency features
- Mutations impacting T-cell and natural killer cell activity
Who Should Consider This Genetic Test
This specialized genetic analysis is recommended for individuals presenting with:
- Recurrent severe bacterial, viral, and fungal infections from early childhood
- Persistent eczema and severe skin infections resistant to conventional treatments
- Elevated serum IgE levels exceeding 2000 IU/mL
- Recurrent pneumonia, sinusitis, or otitis media
- Molluscum contagiosum, herpes simplex, or human papillomavirus infections
- Food allergies and asthma complications
- Family history of similar immune deficiency symptoms
- Neurological manifestations including cerebral aneurysms or vasculitis
Clinical Benefits of DOCK8 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Accurate Diagnosis: Confirms or rules out DOCK8 deficiency with high precision
- Early Intervention: Enables prompt initiation of appropriate treatments
- Family Planning: Provides crucial information for genetic counseling and reproductive decisions
- Treatment Guidance: Informs decisions regarding hematopoietic stem cell transplantation
- Prognostic Information: Helps predict disease progression and potential complications
- Personalized Care: Facilitates development of tailored management strategies
Understanding Your Test Results
Our comprehensive genetic report provides detailed interpretation of your DOCK8 gene analysis:
- Positive Result: Indicates pathogenic mutations in both DOCK8 gene copies, confirming autosomal recessive Hyper-IgE syndrome diagnosis
- Negative Result: No disease-causing mutations detected in the DOCK8 gene
- Variant of Uncertain Significance: Identifies genetic changes with unclear clinical implications requiring further evaluation
- Carrier Status: Detects individuals with one mutated DOCK8 gene copy who may pass the condition to offspring
All results include detailed clinical correlations and recommendations for follow-up care with immunology and genetics specialists.
Test Pricing Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Nationwide Testing Availability
We provide comprehensive genetic testing services across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality results regardless of testing location.
Take Action for Better Health
Don’t let recurrent infections and immune system concerns go undiagnosed. Our DOCK8 Gene Hyper-IgE Recurrent Infection Syndrome NGS Genetic DNA Test provides the clarity needed for effective medical management. With a turnaround time of 3-4 weeks and multiple sample collection options including blood, extracted DNA, or blood spots on FTA cards, getting tested has never been more convenient.
Call us today at +1(267) 388-9828 to schedule your genetic counseling session and book this essential diagnostic test. Our genetic specialists are ready to help you understand your immune health and develop a personalized care plan.
