cKIT Mutation Screening Exons 9, 11, 13, 17 for Gastrointestinal Stromal Tumors
Understanding cKIT Mutation Screening for GIST
cKIT Mutation Screening is a sophisticated genetic test specifically designed for patients diagnosed with Gastrointestinal Stromal Tumors (GIST). This comprehensive analysis focuses on exons 9, 11, 13, and 17 of the cKIT gene, which are critical regions where mutations commonly occur in GIST patients. The test plays a vital role in modern oncology by providing essential information that guides personalized treatment decisions and improves patient outcomes.
What Does the Test Measure?
The cKIT Mutation Screening test detects specific genetic alterations in the cKIT gene using advanced Sanger Sequencing technology. This method precisely identifies:
- Mutations in exon 11 (most common in GIST)
- Genetic variations in exon 9
- Alterations in exon 13 and 17
- Specific point mutations, deletions, and insertions
These mutations are crucial because they activate the cKIT protein, driving uncontrolled cell growth and tumor development in gastrointestinal stromal tumors.
Who Should Consider This Test?
This genetic screening is recommended for individuals with:
- Newly diagnosed Gastrointestinal Stromal Tumors (GIST)
- Recurrent or metastatic GIST
- Patients considering targeted therapy with tyrosine kinase inhibitors
- Those with treatment-resistant GIST
- Patients requiring prognostic information for disease management
Symptoms and Clinical Indications
Patients experiencing abdominal pain, gastrointestinal bleeding, unexplained weight loss, or those with confirmed GIST diagnosis should discuss this testing with their healthcare provider. The test requires a doctor’s prescription and is performed using paraffin-embedded tumor tissue blocks.
Benefits of cKIT Mutation Screening
- Personalized Treatment Planning: Identifies patients who will respond best to targeted therapies
- Prognostic Information: Helps predict disease behavior and progression
- Therapeutic Guidance: Determines optimal dosage and treatment duration for tyrosine kinase inhibitors
- Improved Outcomes: Enhances treatment efficacy and reduces unnecessary side effects
- Comprehensive Analysis: Covers all major mutation sites in the cKIT gene
Understanding Your Test Results
Your cKIT Mutation Screening results will provide detailed information about:
- Mutation Status: Presence or absence of mutations in exons 9, 11, 13, and 17
- Mutation Type: Specific genetic alterations detected
- Clinical Significance: How the findings impact treatment decisions
- Therapeutic Recommendations: Guidance for targeted therapy selection
Positive results indicate the presence of cKIT mutations, which typically respond well to tyrosine kinase inhibitors like imatinib. Negative results may suggest alternative treatment approaches or the need for additional genetic testing.
Test Pricing and Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $300 |
| Regular Price | $400 |
| Turnaround Time | 7-8 days |
| Sample Type | Tumor Tissue (Paraffin embedded blocks) |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure accurate and reliable genetic testing with rapid turnaround times.
Book Your Test Today
Take the first step toward personalized cancer care. Our experienced genetic counselors and oncology specialists are ready to help you understand your genetic profile and develop the most effective treatment strategy. Contact us today to schedule your cKIT Mutation Screening test.
Call or WhatsApp: +1(267) 388-9828
Our team is available to answer your questions, discuss testing requirements, and help you schedule an appointment at your nearest location. Don’t wait – advanced genetic testing can make a significant difference in your treatment journey.
