cKIT Mutation Screening Exons 9, 11, 13, 17 AML
Comprehensive Genetic Analysis for Acute Myeloid Leukemia
The cKIT Mutation Screening Exons 9, 11, 13, 17 AML test represents a cutting-edge genetic diagnostic tool specifically designed for patients with Acute Myeloid Leukemia. This sophisticated screening targets the cKIT gene, a critical receptor tyrosine kinase that plays a pivotal role in cell signaling, proliferation, and differentiation. When mutations occur in specific regions of this gene, particularly exons 9, 11, 13, and 17, they can significantly impact disease progression, treatment response, and overall prognosis in AML patients.
What This Test Measures and Detects
This comprehensive genetic screening utilizes advanced Sanger Sequencing technology to meticulously analyze four crucial exons of the cKIT gene:
- Exon 9: Detects extracellular domain mutations affecting receptor dimerization
- Exon 11: Identifies juxtamembrane domain mutations that disrupt autoinhibition
- Exon 13: Screens for kinase domain mutations impacting ATP binding
- Exon 17: Analyzes activation loop mutations that affect kinase activity
The test specifically looks for point mutations, insertions, and deletions that can activate the cKIT receptor, leading to uncontrolled cell growth and contributing to leukemogenesis in AML patients.
Who Should Consider This Test
This genetic screening is particularly recommended for:
- Patients newly diagnosed with Acute Myeloid Leukemia
- Individuals with core-binding factor AML subtypes (including t(8;21) and inv(16))
- Patients experiencing unexplained fatigue, recurrent infections, or abnormal bleeding
- Those with abnormal blood counts requiring further investigation
- Individuals with a family history of hematological malignancies
- Patients being evaluated for targeted therapy options
Clinical Benefits of cKIT Mutation Screening
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Precise Prognostic Information: cKIT mutations are associated with poorer outcomes in core-binding factor AML
- Treatment Guidance: Results can influence chemotherapy intensity decisions and stem cell transplantation considerations
- Targeted Therapy Opportunities: Identifies patients who may benefit from tyrosine kinase inhibitors
- Disease Monitoring: Establishes baseline mutation status for future monitoring
- Personalized Medicine Approach: Enables tailored treatment strategies based on individual genetic profile
Understanding Your Test Results
Your cKIT mutation screening results will be carefully interpreted by our expert genetic counselors and hematologists:
- Negative Result: No detectable mutations in the screened exons – this may indicate standard risk profile
- Positive Result: Identified mutation(s) in one or more exons – requires detailed interpretation based on mutation type and location
- Variant of Unknown Significance: Rare genetic changes requiring additional clinical correlation
All results are provided with comprehensive explanations and recommendations for next steps in your treatment journey. Our genetic counseling team is available to discuss your results and answer any questions you may have.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | cKIT Mutation Screening Exons 9, 11, 13, 17 AML |
| Regular Price | $250 USD |
| Discount Price | $188 USD |
| Turnaround Time | 7-8 days |
| Sample Type | Peripheral Blood (EDTA Blood 2ml) |
| Testing Method | Sanger Sequencing |
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee.
Take the Next Step in Your Healthcare Journey
Don’t leave your genetic health to chance. The cKIT Mutation Screening provides critical information that can significantly impact your treatment decisions and long-term outcomes. Our experienced team is ready to guide you through the testing process and help you understand what your results mean for your health.
Call us today at +1(267) 388-9828 to schedule your appointment or speak with our genetic counseling team. Take control of your health with comprehensive genetic testing from General Genetics Corporation.
