B-Cell Rearrangement Detection Test
Comprehensive Introduction to B-Cell Rearrangement Analysis
The B-Cell Rearrangement Detection Test represents a cornerstone in modern hematological diagnostics, providing critical insights into B-cell malignancies through sophisticated molecular analysis. This advanced diagnostic procedure examines the unique genetic rearrangements that occur during B-cell development, offering clinicians powerful tools for accurate diagnosis, classification, and monitoring of various hematological disorders.
B-cells undergo a complex process of immunoglobulin gene rearrangement during their maturation, creating unique genetic signatures for each cell lineage. When malignant transformation occurs, this process becomes clonal, producing identical genetic patterns across multiple cells. The detection of these clonal rearrangements serves as a definitive marker for B-cell malignancies, enabling precise diagnosis and targeted treatment approaches.
What the Test Measures and Detects
The B-Cell Rearrangement Detection Test employs cutting-edge PCR fragment analysis to identify specific genetic markers that indicate clonal B-cell populations. The test focuses on several key aspects:
- Immunoglobulin Heavy Chain (IGH) Gene Rearrangements – Analyzes V-D-J recombination patterns
- Immunoglobulin Light Chain Rearrangements – Examines kappa and lambda chain gene configurations
- Clonality Assessment – Determines whether B-cell populations are monoclonal or polyclonal
- Lineage Confirmation – Verifies B-cell origin in uncertain hematological cases
Technical Methodology
Utilizing PCR fragment analysis with capillary electrophoresis, the test provides high-resolution separation and detection of amplified immunoglobulin gene fragments. This methodology offers exceptional sensitivity, capable of detecting clonal populations representing as little as 1-5% of the total cellular population.
Who Should Consider This Test
This advanced diagnostic test is particularly valuable for individuals presenting with symptoms or clinical findings suggestive of B-cell malignancies:
- Unexplained Lymphadenopathy – Persistent swollen lymph nodes without clear infectious cause
- Abnormal Blood Counts – Unexplained lymphocytosis, cytopenias, or abnormal lymphocyte morphology
- Systemic Symptoms – Night sweats, unexplained fever, significant weight loss, or persistent fatigue
- Splenomegaly or Hepatomegaly – Enlarged spleen or liver without clear etiology
- Monitoring Known Conditions – Patients with established B-cell malignancies requiring disease monitoring
- Differential Diagnosis – Cases where reactive lymphoid hyperplasia must be distinguished from malignant processes
Clinical Benefits and Applications
The B-Cell Rearrangement Detection Test offers numerous clinical advantages for patients and healthcare providers:
- Early Disease Detection – Identifies malignant clones before extensive disease progression
- Accurate Diagnosis – Provides definitive evidence of B-cell clonality in ambiguous cases
- Treatment Guidance – Informs therapeutic decisions and helps select appropriate targeted therapies
- Minimal Residual Disease Monitoring – Enables sensitive detection of residual disease after treatment
- Prognostic Information – Assists in risk stratification and outcome prediction
- Cost-Effective Management – Reduces unnecessary treatments through precise diagnosis
Understanding Your Test Results
Interpreting B-Cell Rearrangement Detection results requires careful consideration of clinical context and laboratory findings:
Positive Results
A positive result indicates the presence of a clonal B-cell population, strongly suggesting a B-cell lymphoproliferative disorder. However, correlation with clinical, morphological, and immunophenotypic findings is essential for definitive diagnosis.
Negative Results
A negative result typically indicates polyclonal B-cell populations, which are characteristic of reactive conditions. However, certain technical limitations or unusual genetic rearrangements may occasionally produce false negatives.
Equivocal Results
Some cases may show borderline or oligoclonal patterns requiring additional testing or clinical correlation for accurate interpretation.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $550 |
| Regular Price | $700 |
Test Specifications
- Turnaround Time: 10-12 days
- Sample Requirements: 4 mL (2 mL minimum) whole blood in 1 Lavender top (EDTA) tube
- Shipping Instructions: Ship refrigerated. DO NOT FREEZE
- Required Documentation: Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory
Nationwide Accessibility
We maintain comprehensive testing facilities across the United States, ensuring convenient access to advanced molecular diagnostics. Our network includes specialized centers in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Each facility maintains the same high standards of quality and expertise in molecular hematopathology.
Take Action for Your Health
Early detection and accurate diagnosis are crucial for successful management of hematological conditions. The B-Cell Rearrangement Detection Test provides the definitive information needed for appropriate treatment planning and optimal patient outcomes.
Schedule your B-Cell Rearrangement Detection Test today by calling our dedicated healthcare line at +1(267) 388-9828 or book your appointment online through our secure patient portal. Our experienced genetic counselors and hematology specialists are available to discuss your testing needs and answer any questions you may have about the procedure and its clinical implications.
Don’t delay in obtaining the critical diagnostic information necessary for your hematological health. Contact us now to schedule your comprehensive B-cell clonality assessment and take the first step toward precise diagnosis and targeted treatment.
