KRAS Mutation Codon 12 & 13 Test
Understanding KRAS Mutation Testing
The KRAS Mutation Codon 12 & 13 Test represents a breakthrough in precision oncology, offering critical insights into cancer treatment response and progression. KRAS (Kirsten rat sarcoma viral oncogene homolog) is one of the most frequently mutated genes in human cancers, and mutations at specific codons can significantly impact treatment outcomes and disease management strategies.
What is the KRAS Gene and Why Does It Matter?
The KRAS gene encodes a protein that functions as a molecular switch in cellular signaling pathways, particularly those regulating cell growth and division. When mutations occur at codons 12 or 13, the KRAS protein becomes permanently activated, leading to uncontrolled cell proliferation and cancer development. Understanding these specific mutations is crucial because they can predict resistance to certain targeted therapies, particularly EGFR inhibitors used in colorectal cancer treatment.
What the Test Measures and Detects
This advanced molecular diagnostic test specifically identifies mutations at codons 12 and 13 of the KRAS gene using sophisticated PCR and fragment analysis techniques. The test examines:
- Specific point mutations at codon positions 12 and 13
- Common substitution mutations including G12D, G12V, G12C, G12A, G12S, G12R, and G13D
- Activating mutations that drive cancer progression
- Mutations that confer resistance to targeted therapies
Who Should Consider This Test
This test is recommended for patients with specific cancer types where KRAS mutation status directly impacts treatment decisions:
Primary Indications
- Patients diagnosed with metastatic colorectal cancer
- Individuals with advanced pancreatic cancer
- Patients with non-small cell lung cancer
- Those being considered for anti-EGFR therapy
- Patients with treatment-resistant cancers
Symptoms and Clinical Scenarios
- Newly diagnosed colorectal cancer patients
- Patients experiencing disease progression despite standard treatments
- Individuals with family history of colorectal cancer
- Patients being evaluated for personalized therapy options
Benefits of KRAS Mutation Testing
Undergoing KRAS mutation analysis provides numerous clinical advantages:
Personalized Treatment Planning
- Identifies patients who will benefit from anti-EGFR therapies
- Prevents unnecessary treatment with ineffective medications
- Reduces exposure to potential side effects from inappropriate therapies
- Enables selection of alternative effective treatment options
Improved Clinical Outcomes
- Optimizes treatment response rates
- Reduces healthcare costs by avoiding ineffective treatments
- Provides valuable prognostic information
- Supports enrollment in clinical trials for targeted therapies
Understanding Your Test Results
Interpreting KRAS mutation test results requires careful consideration by your healthcare provider:
Possible Results and Their Meanings
- KRAS Mutation Detected: Indicates the presence of specific mutations at codons 12 or 13, which may predict resistance to anti-EGFR therapies. Your oncologist will consider alternative treatment strategies.
- No KRAS Mutation Detected: Suggests that anti-EGFR therapies may be effective treatment options. This result supports the use of targeted biological agents.
- Insufficient Sample or Invalid Result: May require sample recollection or alternative testing methods to obtain accurate results.
Clinical Implications
Your test results will be thoroughly reviewed by our molecular pathology team and discussed with your healthcare provider. The interpretation considers:
- Specific mutation type and location
- Cancer type and stage
- Current treatment guidelines
- Available therapeutic options
- Individual patient factors
Test Information and Pricing
| Test Name | Discount Price | Regular Price |
|---|---|---|
| KRAS Mutation Codon 12 & 13 Test | $250 USD | $376 USD |
Test Specifications
- Turnaround Time: Sample submitted Tuesday by 11 AM; Report available Monday
- Sample Type: Formalin-fixed paraffin-embedded tissue block with at least 10% tumor tissue
- Shipping: Room temperature
- Required Documentation: Duly filled NGS Test Requisition Form (Form 40)
- Testing Method: PCR and Fragment Analysis
Nationwide Availability and Booking
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art molecular diagnostics laboratories ensure accurate and timely results for patients nationwide.
Take Action Today
Don’t let uncertainty about your cancer treatment options delay your care. The KRAS Mutation Codon 12 & 13 Test provides critical information that can significantly impact your treatment success and quality of life. Our experienced team is ready to assist you with scheduling, sample collection, and result interpretation.
Book your KRAS Mutation Test today or call our dedicated healthcare line at +1(267) 388-9828 to speak with a genetic counseling specialist. Take the first step toward personalized cancer care and informed treatment decisions.
