HLA Hypersensitivity to Allopurinol B5801 Test
Understanding Allopurinol Hypersensitivity Risk
The HLA Hypersensitivity to Allopurinol B5801 Test represents a groundbreaking advancement in personalized medicine and drug safety. This genetic screening test specifically detects the presence of the HLA-B*58:01 allele, a genetic marker strongly associated with severe hypersensitivity reactions to allopurinol medication. Allopurinol is widely prescribed for managing gout and hyperuricemia, but for individuals carrying this specific genetic variant, the medication can trigger potentially life-threatening adverse reactions.
What Does This Test Measure?
This sophisticated genetic test utilizes advanced PCR and sequencing methodologies to identify the presence of the HLA-B*58:01 allele in your DNA. The test specifically targets:
- HLA-B*58:01 genetic variant detection
- Genetic predisposition to allopurinol hypersensitivity
- Risk assessment for severe cutaneous adverse reactions
- Personalized medication safety profiling
Who Should Consider This Test?
This test is particularly recommended for individuals in the following categories:
- Patients being considered for allopurinol therapy for gout management
- Individuals of Asian descent, particularly Han Chinese, Thai, and Korean populations
- Patients with a family history of medication hypersensitivity reactions
- Those who have experienced previous adverse drug reactions
- Patients with chronic kidney disease requiring gout treatment
- Individuals scheduled for long-term allopurinol therapy
Clinical Indications and Symptoms of Concern
Patients experiencing or at risk for the following conditions should strongly consider this test:
- Severe skin rashes developing after allopurinol initiation
- History of Stevens-Johnson syndrome or toxic epidermal necrolysis
- Drug reaction with eosinophilia and systemic symptoms (DRESS)
- Unexplained fever, liver dysfunction, or renal impairment during allopurinol treatment
- Generalized maculopapular eruptions with systemic symptoms
Benefits of HLA B5801 Testing
Undergoing this genetic screening provides numerous clinical advantages:
- Prevention of Life-Threatening Reactions: Identifies patients at high risk before allopurinol initiation
- Personalized Treatment Planning: Enables selection of alternative gout medications for high-risk individuals
- Enhanced Medication Safety: Reduces the incidence of severe cutaneous adverse reactions by up to 97%
- Cost-Effective Healthcare: Prevents expensive hospitalizations and complications from adverse drug reactions
- Peace of Mind: Provides confidence in medication safety for both patients and healthcare providers
- Regulatory Compliance: Aligns with FDA recommendations for genetic testing in specific populations
Understanding Your Test Results
Your HLA B5801 test results will fall into one of two categories, each with specific clinical implications:
Positive Result (HLA-B*58:01 Detected)
- Indicates high genetic risk for allopurinol hypersensitivity
- Strong recommendation to avoid allopurinol therapy
- Alternative gout medications should be considered
- Carries approximately 580-fold increased risk of severe cutaneous adverse reactions
- Requires careful documentation in medical records
Negative Result (HLA-B*58:01 Not Detected)
- Indicates low genetic risk for allopurinol hypersensitivity
- Allopurinol can be considered as a treatment option
- Standard monitoring for adverse effects still recommended
- Does not eliminate risk of other types of drug reactions
- Provides genetic clearance for allopurinol therapy initiation
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | HLA Hypersensitivity to Allopurinol B5801 Test |
| Discount Price | $200 USD |
| Regular Price | $300 USD |
| Turnaround Time | 10-12 days |
| Sample Type | 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube OR Buccal swab collected in a sterile container |
| Shipping Instructions | Ship refrigerated. DO NOT FREEZE |
| Preparation | No special preparation required |
| Testing Methodology | PCR, Sequencing |
Nationwide Testing Availability
We have comprehensive testing facilities across the United States, with convenient locations in all major metropolitan areas including New York City, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee. Our network ensures accessible genetic testing services for patients throughout the country.
Take Control of Your Medication Safety
Don’t leave your medication safety to chance. The HLA Hypersensitivity to Allopurinol B5801 Test provides crucial genetic information that can prevent serious adverse drug reactions and ensure safe gout treatment. With our discounted price of $200 USD and comprehensive nationwide coverage, there’s no reason to delay this important health assessment.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Our genetic counseling team is available to answer your questions and guide you through the testing process.
Take the first step toward personalized, safe medication management. Your genetic profile holds the key to preventing potentially life-threatening drug reactions and optimizing your treatment outcomes.
