HLA Panel Reactive IgG Antibodies PRA Screen Test
Comprehensive Introduction to HLA Antibody Screening
The HLA Panel Reactive IgG Antibodies PRA Screen Test represents a cornerstone in modern transplant medicine, providing essential immunological assessment for patients awaiting organ transplantation. This sophisticated diagnostic tool evaluates the presence and concentration of IgG antibodies directed against human leukocyte antigens (HLA), which play a critical role in determining transplant compatibility and predicting potential rejection episodes.
What Does This Test Measure?
The HLA PRA Screen Test specifically detects and quantifies IgG antibodies targeting:
- Class I HLA Antigens: HLA-A, HLA-B, and HLA-C antigens present on virtually all nucleated cells
- Class II HLA Antigens: HLA-DR, HLA-DQ, and HLA-DP antigens primarily found on immune cells
Using advanced Luminex X-Map technology, this test provides highly sensitive and specific detection of donor-specific antibodies that could trigger immune-mediated rejection following transplantation. The methodology offers superior precision compared to traditional cell-based assays, enabling more accurate risk stratification and treatment planning.
Who Should Consider HLA PRA Screening?
Primary Candidates for Testing
- Transplant Candidates: All patients being evaluated for solid organ transplantation (kidney, heart, liver, lung, pancreas)
- Previous Transplant Recipients: Individuals with history of prior organ transplants
- Sensitized Patients: Those with known HLA sensitization from blood transfusions, pregnancies, or previous transplants
- High-Risk Populations: Patients with autoimmune conditions or multiple previous exposures to foreign HLA antigens
Clinical Indications
This test is particularly crucial for patients under the care of:
- Nephrologists: Managing kidney transplant candidates and recipients
- Gastroenterologists: Overseeing liver and intestinal transplant evaluations
- Hematologists: Coordinating bone marrow and stem cell transplantation
- Transplant Surgeons: Assessing immunological risk before proceeding with transplantation
Significant Benefits of HLA PRA Screening
Enhanced Transplant Success
- Risk Assessment: Identifies patients at high risk for antibody-mediated rejection
- Donor Selection: Guides appropriate donor matching to minimize immunological complications
- Treatment Planning: Informs pre-transplant desensitization protocols when necessary
- Outcome Prediction: Helps forecast long-term graft survival and function
Patient-Specific Advantages
- Personalized Care: Enables tailored immunosuppression regimens
- Reduced Complications: Minimizes risk of early and late rejection episodes
- Improved Survival: Contributes to better long-term transplant outcomes
- Informed Decision-Making: Provides critical data for patients and healthcare teams
Understanding Your Test Results
Interpretation Guidelines
Your HLA PRA Screen results will provide valuable information about your immunological status:
- Low PRA (0-10%): Indicates minimal pre-existing HLA antibodies, suggesting lower rejection risk
- Moderate PRA (11-79%): Shows some degree of sensitization, requiring careful donor matching
- High PRA (80-100%): Significant sensitization present, may require specialized desensitization protocols
Clinical Implications
Results are interpreted in the context of your complete medical history, including previous transplants, pregnancies, and blood transfusions. Your transplant team will use this information to:
- Determine appropriate donor compatibility criteria
- Develop personalized immunosuppression strategies
- Plan potential desensitization treatments if needed
- Establish realistic expectations for transplant outcomes
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $212 |
| Regular Price | $300 |
Test Specifications
- Turnaround Time: 10-12 days
- Sample Type: 3 mL (1.5 mL min.) serum from 1 SST
- Shipping Requirements: Ship refrigerated or frozen
- Special Instructions: Collect specimen preferably 48 hours after dialysis. Provide brief clinical history.
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including:
- New York City and surrounding regions
- Los Angeles and Southern California
- Chicago and the Midwest
- Houston and Texas medical centers
- Miami and Florida healthcare facilities
- Philadelphia and the Northeast corridor
- San Francisco Bay Area
- Boston medical community
Take the Next Step Toward Transplant Success
Don’t leave your transplant outcome to chance. The HLA Panel Reactive IgG Antibodies PRA Screen Test provides the critical immunological information needed for successful transplantation. Our experienced team is ready to assist you with this essential pre-transplant evaluation.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your HLA PRA Screen Test and take the first step toward a successful transplant journey.
Our dedicated transplant testing specialists are available to answer your questions, explain the testing process, and help coordinate your specimen collection. With rapid 10-12 day turnaround times and comprehensive reporting, we provide the timely information your medical team needs to make informed decisions about your transplant care.
