HLA DR DQB1 Class II Typing Test
Understanding HLA Typing for Transplantation Success
The HLA DR DQB1 Class II Typing Test represents a cornerstone of modern transplant medicine, providing essential genetic information that determines compatibility between organ donors and recipients. This sophisticated analysis focuses on specific human leukocyte antigen (HLA) markers within the Class II region, which are critical for immune system recognition and response. By examining the DR and DQB1 loci, healthcare providers can make informed decisions about transplant suitability and optimize patient outcomes.
What Does This Test Measure?
The HLA DR DQB1 Class II Typing Test specifically analyzes:
- HLA-DR antigens (DRB1 locus) that regulate immune responses
- HLA-DQB1 antigens involved in antigen presentation
- Genetic variations that influence transplant acceptance or rejection
- Immunological compatibility markers for donor-recipient matching
Who Should Consider HLA DR DQB1 Testing?
This specialized genetic testing is essential for:
- Transplant Candidates: Patients awaiting kidney, liver, heart, lung, or pancreas transplantation
- Bone Marrow Recipients: Individuals requiring hematopoietic stem cell transplantation
- Living Donor Evaluation: Potential donors being assessed for compatibility
- Family Members: Relatives being considered as living donors
- Patients with Autoimmune Conditions: Those where HLA typing aids in disease diagnosis and management
Clinical Indications and Symptoms
Patients typically require HLA typing when facing:
- End-stage renal disease requiring kidney transplantation
- Liver failure necessitating liver transplant evaluation
- Hematological malignancies requiring bone marrow transplantation
- Cardiac or pulmonary conditions where organ replacement is indicated
- Genetic predisposition to autoimmune disorders
Benefits of HLA DR DQB1 Class II Typing
Undergoing comprehensive HLA testing provides numerous advantages:
- Improved Transplant Success: Better matching reduces rejection risks
- Personalized Treatment: Enables tailored immunosuppression regimens
- Faster Donor Identification: Accelerates compatible donor matching process
- Reduced Complications: Minimizes graft-versus-host disease risks
- Long-term Health Outcomes: Enhances transplant longevity and patient survival
Advanced Testing Methodology
Our laboratory employs state-of-the-art Reverse Sequence Specific Oligonucleotide Probe (SSOP) Luminex technology, which offers:
- High-resolution typing with exceptional accuracy
- Comprehensive allele detection capabilities
- Rapid turnaround time of 10-12 days
- Reliable results for critical medical decisions
Understanding Your Test Results
Your HLA typing results will provide detailed information about:
- HLA-DR Typing: Specific DRB1 alleles identified
- HLA-DQB1 Typing: DQB1 allele combinations detected
- Compatibility Assessment: How well your HLA profile matches potential donors
- Clinical Interpretation: Expert analysis of what the results mean for your transplant journey
Our genetic specialists will help you understand your results and their implications for transplant planning. Higher HLA matching typically correlates with better transplant outcomes and reduced rejection episodes.
Test Pricing and Availability
| Test Description | Price (USD) |
|---|---|
| HLA DR DQB1 Class II Typing Test – Discount Price | $258 |
| HLA DR DQB1 Class II Typing Test – Regular Price | $288 |
Sample Requirements and Preparation
For accurate testing, please provide:
- 4 mL (3 mL minimum) whole blood in 1 Lavender Top (EDTA) tube OR
- 6 mL (3 mL minimum) whole blood in 1 Yellow Top (ACD) tube
- Ship refrigerated – DO NOT FREEZE
- Doctor’s prescription on letterhead with 1 photograph each of recipient and donor duly stamped
- Consent form for HLA Typing for Solid Organ Transplant (Form 33) is mandatory
Nationwide Testing Availability
GGC DNA provides comprehensive HLA testing services across the United States, with convenient locations in major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified laboratories ensures consistent, high-quality results regardless of your location.
Take the Next Step in Your Transplant Journey
Don’t leave your transplant success to chance. Our specialized HLA typing services provide the critical genetic information needed for optimal donor matching and improved transplant outcomes. With rapid 10-12 day turnaround and competitive pricing at $258 USD, there’s no reason to delay this essential testing.
Ready to begin your HLA typing? Contact our transplant genetics specialists today at +1(267) 388-9828 or book your test online to schedule your comprehensive evaluation.
Our team of genetic counselors and transplant coordinators are available to answer your questions and guide you through the testing process. Trust GGC DNA for accurate, reliable HLA typing that makes a difference in your transplant journey.
