FISH t(8;14) or MYC/IGH for Burkitt Non-Hodgkin Lymphoma Test
Comprehensive Diagnostic Testing for Burkitt Lymphoma
The FISH t(8;14) or MYC/IGH for Burkitt Non-Hodgkin Lymphoma Test represents a critical advancement in molecular diagnostics for hematologic malignancies. This sophisticated cytogenetic analysis specifically targets the chromosomal abnormalities that define Burkitt lymphoma, one of the most aggressive forms of non-Hodgkin lymphoma. By detecting the characteristic t(8;14) translocation involving the MYC oncogene and immunoglobulin heavy chain (IGH) locus, this test provides clinicians with definitive diagnostic information essential for accurate classification and targeted treatment planning.
What This Test Measures and Detects
The FISH t(8;14) or MYC/IGH test utilizes fluorescence in situ hybridization (FISH) technology to identify specific genetic rearrangements:
- MYC/IGH Translocation Detection: Identifies the t(8;14)(q24;q32) chromosomal translocation
- Oncogene Activation: Detects the repositioning of the MYC oncogene next to immunoglobulin heavy chain enhancers
- Lymphoma Classification: Confirms the diagnosis of Burkitt lymphoma versus other B-cell malignancies
- Treatment Guidance: Provides critical information for selecting appropriate chemotherapy regimens
Who Should Consider This Test
This specialized test is recommended for individuals presenting with symptoms suggestive of aggressive lymphoma:
- Patients with rapidly enlarging lymph nodes or abdominal masses
- Individuals experiencing unexplained weight loss, night sweats, or persistent fever
- Those with elevated lactate dehydrogenase (LDH) levels
- Patients with suspected Burkitt lymphoma based on initial biopsy findings
- Individuals requiring definitive classification of aggressive B-cell lymphoma
- Patients being evaluated for treatment response monitoring
Clinical Benefits of Testing
Undergoing the FISH t(8;14) or MYC/IGH test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms Burkitt lymphoma with high specificity
- Treatment Personalization: Guides selection of appropriate intensive chemotherapy protocols
- Prognostic Information: Helps predict disease behavior and treatment response
- Therapeutic Monitoring: Assists in evaluating treatment effectiveness
- Differential Diagnosis: Distinguishes Burkitt lymphoma from other aggressive lymphomas
Understanding Your Test Results
Your test results will provide critical information about the presence or absence of the MYC/IGH translocation:
- Positive Result: Indicates the presence of t(8;14) translocation, confirming Burkitt lymphoma diagnosis
- Negative Result: Suggests absence of the specific translocation, requiring consideration of other lymphoma subtypes
- Interpretation Guidance: Results should be interpreted by qualified hematologists or oncologists in clinical context
- Clinical Correlation: Test findings must be correlated with histopathology and other laboratory results
Test Pricing Information
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $150 |
| Regular Price | $188 |
Test Specifications and Requirements
Turnaround Time: Sample accepted daily by 4 pm; Report available in 4 working days
Sample Type: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes
Shipping Instructions: Ship at 18-22°C. DO NOT FREEZE
Required Documentation: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
Nationwide Testing Availability
GGC DNA maintains testing facilities across the United States, with convenient locations in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our nationwide network ensures accessible, high-quality diagnostic services for patients throughout the country.
Take Action for Your Health
Early and accurate diagnosis is crucial for successful management of Burkitt lymphoma. Our specialized FISH testing provides the definitive genetic information needed for appropriate treatment planning. Don’t delay in obtaining the critical diagnostic information necessary for your healthcare journey.
Book your FISH t(8;14) or MYC/IGH for Burkitt Non-Hodgkin Lymphoma Test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your appointment online. Our experienced genetic counselors and healthcare professionals are available to assist you with testing coordination and result interpretation.
