BCR-ABL Gene Rearrangement PCR Qualitative Test
Understanding the BCR-ABL Gene Rearrangement Test
The BCR-ABL Gene Rearrangement PCR Qualitative Test represents a cornerstone in modern molecular diagnostics for hematological malignancies. This sophisticated test detects the presence of the Philadelphia chromosome, a specific genetic abnormality resulting from a translocation between chromosomes 9 and 22. This chromosomal rearrangement creates the BCR-ABL fusion gene, which produces an abnormal protein that drives uncontrolled cell growth in certain types of leukemia.
What This Test Measures and Detects
This advanced molecular test specifically identifies:
- The presence of BCR-ABL fusion gene transcripts
- The Philadelphia chromosome abnormality at the molecular level
- Specific breakpoint regions within the BCR and ABL genes
- Qualitative detection of the genetic rearrangement
Using Real-Time PCR technology, the test amplifies and detects minute quantities of the fusion gene with exceptional sensitivity, making it invaluable for both initial diagnosis and monitoring treatment response.
Who Should Consider This Test?
Clinical Indications and Symptoms
This test is recommended for individuals experiencing:
- Unexplained fatigue and weakness
- Unintentional weight loss and night sweats
- Abdominal discomfort or fullness due to spleen enlargement
- Frequent infections and bleeding tendencies
- Abnormal blood counts showing elevated white blood cells
- Suspected chronic myeloid leukemia (CML)
- Certain types of acute lymphoblastic leukemia (ALL)
- Patients with family history of hematological malignancies
Medical Referral Considerations
Consultation with an oncologist or hematologist is recommended if you experience persistent symptoms or have risk factors for leukemia. Early detection significantly improves treatment outcomes and quality of life.
Benefits of BCR-ABL Testing
Choosing the BCR-ABL Gene Rearrangement PCR Qualitative Test offers numerous advantages:
- Early Diagnosis: Enables detection of leukemia at earliest stages
- Treatment Guidance: Helps determine appropriate targeted therapy
- Monitoring Tool: Tracks treatment response and disease progression
- High Sensitivity: Detects minimal residual disease
- Prognostic Value: Provides important information about disease course
- Non-Invasive: Simple blood draw with minimal discomfort
Understanding Your Test Results
Interpretation Guidelines
Your test results will fall into one of these categories:
Positive Result
A positive result indicates the presence of the BCR-ABL fusion gene, confirming the diagnosis of Philadelphia chromosome-positive leukemia. This finding typically leads to:
- Initiation of targeted tyrosine kinase inhibitor therapy
- Regular monitoring of treatment response
- Comprehensive hematological evaluation
- Genetic counseling and family risk assessment
Negative Result
A negative result suggests the absence of the BCR-ABL fusion gene. However, this does not completely rule out other forms of leukemia or hematological disorders. Further testing may be recommended based on clinical presentation.
Clinical Follow-up
All results should be discussed with your healthcare provider, who will interpret them in the context of your complete medical history, physical examination findings, and other laboratory tests.
Test Information and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | BCR-ABL Gene Rearrangement PCR Qualitative Test |
| Regular Price | $150 USD |
| Discount Price | $126 USD |
| Sample Type | 5 mL (3 mL min.) whole blood / Bone marrow in 1 Lavender Top (EDTA) tube |
| Turnaround Time | Sample Mon/Wed/Fri by 9 am; Report Tue/Thu/Sat |
| Methodology | Real-Time PCR |
| Specialty | Oncology, Hematology |
Convenient Testing Locations Across USA
GGC DNA provides comprehensive BCR-ABL testing services throughout the United States. Our state-of-the-art molecular diagnostics laboratories serve patients in:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and Midwest regions
- Houston and Texas metropolitan areas
- Miami and Florida locations
- All major urban centers nationwide
Take Action for Your Health Today
Early detection of leukemia through BCR-ABL testing can significantly impact treatment success and long-term outcomes. Don’t wait to address concerning symptoms or risk factors.
Book your BCR-ABL Gene Rearrangement PCR Qualitative Test today at our special discounted rate of $126 USD. Our experienced healthcare team is ready to provide you with accurate testing and comprehensive support throughout your diagnostic journey.
Call or WhatsApp us now at +1(267) 388-9828 to schedule your appointment or to speak with our genetic counseling specialists. Take the first step toward understanding your health with confidence and precision.
