MSH6 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test
Comprehensive Genetic Screening for Hereditary Cancer Risk
The MSH6 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test represents a breakthrough in personalized cancer risk assessment. This advanced genetic screening test specifically targets the MSH6 gene, a crucial component of the DNA mismatch repair system that maintains genomic stability and prevents cancer development. When mutations occur in the MSH6 gene, individuals face significantly elevated risks for developing Lynch syndrome-associated cancers throughout their lifetime.
What Does This Test Measure and Detect?
This sophisticated genetic analysis utilizes Next-Generation Sequencing (NGS) technology to comprehensively examine the MSH6 gene for pathogenic variants, including:
- Point mutations affecting single DNA nucleotides
- Small insertions and deletions within the gene sequence
- Large genomic rearrangements and structural variations
- Copy number variations affecting gene dosage
- Splice site mutations impacting protein production
The test specifically identifies mutations that disrupt the DNA mismatch repair pathway, which normally corrects errors that occur during DNA replication. When this system fails due to MSH6 mutations, cells accumulate genetic errors at an accelerated rate, dramatically increasing cancer susceptibility.
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals who meet any of the following criteria:
- Family History Patterns: Multiple relatives diagnosed with colorectal, endometrial, ovarian, gastric, or urinary tract cancers
- Early-Onset Cancer: Personal diagnosis of colorectal cancer before age 50
- Multiple Primary Cancers: Individuals with two or more Lynch syndrome-related cancers
- Abnormal Tumor Testing: Microsatellite instability (MSI) or immunohistochemistry showing loss of MSH6 protein expression in tumor tissue
- Known Family Mutation: Relatives with confirmed MSH6 gene mutations
- Unexplained Cancer Clusters: Families with multiple generations affected by Lynch-associated cancers
Clinical Benefits of MSH6 Genetic Testing
Undergoing MSH6 genetic testing provides numerous significant advantages for proactive health management:
- Personalized Cancer Surveillance: Enables tailored screening protocols based on individual genetic risk
- Early Detection Opportunities: Facilitates cancer detection at earlier, more treatable stages
- Informed Family Planning: Provides crucial information for reproductive decision-making
- Risk-Reduction Strategies: Guides implementation of preventive measures and lifestyle modifications
- Treatment Guidance: Informs therapeutic decisions for cancer patients with MSH6 mutations
- Family Member Screening: Identifies at-risk relatives who may benefit from genetic testing
- Psychological Relief: Reduces uncertainty and anxiety through definitive risk assessment
Understanding Your Test Results
Your MSH6 genetic test results will fall into one of several categories, each with specific implications:
- Positive Result: A pathogenic mutation is identified, confirming Lynch syndrome diagnosis and indicating significantly increased cancer risks requiring enhanced surveillance
- Negative Result: No mutation detected in an individual with known family mutation, indicating the person did not inherit the familial cancer predisposition
- Variant of Uncertain Significance (VUS): A genetic change is identified, but its clinical significance is currently unknown, requiring ongoing monitoring and research
- No Mutation Detected: In families without known mutations, this result reduces but does not eliminate Lynch syndrome risk due to possible limitations in testing sensitivity
All positive results should be discussed with a certified genetic counselor who can provide comprehensive risk assessment, family testing recommendations, and personalized management strategies.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | MSH6 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Methodology | Next-Generation Sequencing (NGS) Technology |
| Specialty | Oncology and Genetics |
Pre-Test Requirements and Preparation
To ensure accurate testing and comprehensive interpretation, the following preparations are essential:
- Clinical History Documentation: Complete medical and family history of the patient undergoing testing
- Genetic Counseling Session: Mandatory pre-test genetic counseling to discuss testing implications, limitations, and potential outcomes
- Family Pedigree Chart: Detailed documentation of family members affected by MSH6-related cancers across multiple generations
- Informed Consent: Thorough understanding and signed consent acknowledging test implications and potential psychological impact
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network of certified genetic counselors and medical professionals ensures accessible, high-quality care regardless of your location.
Take Control of Your Genetic Health Today
Don’t leave your cancer risk to chance. The MSH6 Gene Mismatch Repair Cancer Syndrome NGS Genetic DNA Test provides definitive answers that can guide life-saving preventive measures and surveillance strategies. Our team of board-certified genetic counselors and oncology specialists are ready to support you through every step of the testing process.
Call us today at +1(267) 388-9828 to schedule your genetic counseling session and testing appointment. Take the first step toward understanding your hereditary cancer risk and implementing personalized prevention strategies that could save your life.
